0s autopkgtest [04:59:34]: starting date and time: 2025-03-04 04:59:34+0000 0s autopkgtest [04:59:34]: git checkout: 325255d2 Merge branch 'pin-any-arch' into 'ubuntu/production' 0s autopkgtest [04:59:34]: host juju-7f2275-prod-proposed-migration-environment-20; command line: /home/ubuntu/autopkgtest/runner/autopkgtest --output-dir /tmp/autopkgtest-work.cv7lvk6b/out --timeout-copy=6000 --setup-commands /home/ubuntu/autopkgtest-cloud/worker-config-production/setup-canonical.sh --apt-pocket=proposed=src:r-cran-mass --apt-upgrade r-cran-dosefinding --timeout-short=300 --timeout-copy=20000 --timeout-build=20000 --env=ADT_TEST_TRIGGERS=r-cran-mass/7.3-65-1 -- ssh -s /home/ubuntu/autopkgtest/ssh-setup/nova -- --flavor autopkgtest --security-groups autopkgtest-juju-7f2275-prod-proposed-migration-environment-20@lcy02-1.secgroup --name adt-plucky-amd64-r-cran-dosefinding-20250304-045934-juju-7f2275-prod-proposed-migration-environment-20-359108a5-42a9-4167-9a53-fd454b4edb04 --image adt/ubuntu-plucky-amd64-server --keyname testbed-juju-7f2275-prod-proposed-migration-environment-20 --net-id=net_prod-proposed-migration -e TERM=linux -e ''"'"'http_proxy=http://squid.internal:3128'"'"'' -e ''"'"'https_proxy=http://squid.internal:3128'"'"'' -e ''"'"'no_proxy=127.0.0.1,127.0.1.1,login.ubuntu.com,localhost,localdomain,novalocal,internal,archive.ubuntu.com,ports.ubuntu.com,security.ubuntu.com,ddebs.ubuntu.com,changelogs.ubuntu.com,keyserver.ubuntu.com,launchpadlibrarian.net,launchpadcontent.net,launchpad.net,10.24.0.0/24,keystone.ps5.canonical.com,objectstorage.prodstack5.canonical.com,radosgw.ps5.canonical.com'"'"'' --mirror=http://ftpmaster.internal/ubuntu/ 50s autopkgtest [05:00:24]: testbed dpkg architecture: amd64 50s autopkgtest [05:00:24]: testbed apt version: 2.9.31ubuntu1 50s autopkgtest [05:00:24]: @@@@@@@@@@@@@@@@@@@@ test bed setup 51s autopkgtest [05:00:25]: testbed release detected to be: None 51s autopkgtest [05:00:25]: updating testbed package index (apt update) 51s Get:1 http://ftpmaster.internal/ubuntu plucky-proposed InRelease [110 kB] 51s Hit:2 http://ftpmaster.internal/ubuntu plucky InRelease 51s Hit:3 http://ftpmaster.internal/ubuntu plucky-updates InRelease 51s Hit:4 http://ftpmaster.internal/ubuntu plucky-security InRelease 51s Get:5 http://ftpmaster.internal/ubuntu plucky-proposed/multiverse Sources [19.1 kB] 51s Get:6 http://ftpmaster.internal/ubuntu plucky-proposed/restricted Sources [2420 B] 51s Get:7 http://ftpmaster.internal/ubuntu plucky-proposed/universe Sources [492 kB] 51s Get:8 http://ftpmaster.internal/ubuntu plucky-proposed/main Sources [54.7 kB] 51s Get:9 http://ftpmaster.internal/ubuntu plucky-proposed/main i386 Packages [83.4 kB] 51s Get:10 http://ftpmaster.internal/ubuntu plucky-proposed/main amd64 Packages [118 kB] 51s Get:11 http://ftpmaster.internal/ubuntu plucky-proposed/restricted amd64 Packages [13.2 kB] 51s Get:12 http://ftpmaster.internal/ubuntu plucky-proposed/universe amd64 Packages [521 kB] 51s Get:13 http://ftpmaster.internal/ubuntu plucky-proposed/universe i386 Packages [302 kB] 51s Get:14 http://ftpmaster.internal/ubuntu plucky-proposed/multiverse i386 Packages [10.9 kB] 51s Get:15 http://ftpmaster.internal/ubuntu plucky-proposed/multiverse amd64 Packages [23.5 kB] 51s Fetched 1750 kB in 0s (6454 kB/s) 52s Reading package lists... 53s Reading package lists... 53s Building dependency tree... 53s Reading state information... 53s Calculating upgrade... 54s Calculating upgrade... 54s 0 upgraded, 0 newly installed, 0 to remove and 0 not upgraded. 54s Reading package lists... 54s Building dependency tree... 54s Reading state information... 55s Solving dependencies... 55s 0 upgraded, 0 newly installed, 0 to remove and 0 not upgraded. 55s autopkgtest [05:00:29]: upgrading testbed (apt dist-upgrade and autopurge) 55s Reading package lists... 55s Building dependency tree... 55s Reading state information... 56s Calculating upgrade...Starting pkgProblemResolver with broken count: 0 56s Starting 2 pkgProblemResolver with broken count: 0 56s Done 57s Entering ResolveByKeep 57s 58s Calculating upgrade... 58s 0 upgraded, 0 newly installed, 0 to remove and 0 not upgraded. 58s Reading package lists... 58s Building dependency tree... 58s Reading state information... 59s Starting pkgProblemResolver with broken count: 0 59s Starting 2 pkgProblemResolver with broken count: 0 59s Done 59s Solving dependencies... 59s 0 upgraded, 0 newly installed, 0 to remove and 0 not upgraded. 60s autopkgtest [05:00:34]: testbed running kernel: Linux 6.12.0-16-generic #16-Ubuntu SMP PREEMPT_DYNAMIC Fri Feb 14 15:11:11 UTC 2025 60s autopkgtest [05:00:34]: @@@@@@@@@@@@@@@@@@@@ apt-source r-cran-dosefinding 61s Get:1 http://ftpmaster.internal/ubuntu plucky/universe r-cran-dosefinding 1.2-1-1 (dsc) [2322 B] 61s Get:2 http://ftpmaster.internal/ubuntu plucky/universe r-cran-dosefinding 1.2-1-1 (tar) [696 kB] 61s Get:3 http://ftpmaster.internal/ubuntu plucky/universe r-cran-dosefinding 1.2-1-1 (diff) [4224 B] 61s gpgv: Signature made Tue Sep 10 05:38:46 2024 UTC 61s gpgv: using RSA key 73471499CC60ED9EEE805946C5BD6C8F2295D502 61s gpgv: issuer "plessy@debian.org" 61s gpgv: Can't check signature: No public key 61s dpkg-source: warning: cannot verify inline signature for ./r-cran-dosefinding_1.2-1-1.dsc: no acceptable signature found 61s autopkgtest [05:00:35]: testing package r-cran-dosefinding version 1.2-1-1 62s autopkgtest [05:00:36]: build not needed 65s autopkgtest [05:00:39]: test run-unit-test: preparing testbed 65s Reading package lists... 66s Building dependency tree... 66s Reading state information... 66s Starting pkgProblemResolver with broken count: 0 66s Starting 2 pkgProblemResolver with broken count: 0 66s Done 67s The following NEW packages will be installed: 67s fontconfig fontconfig-config fonts-dejavu-core fonts-dejavu-mono 67s fonts-font-awesome fonts-glyphicons-halflings fonts-mathjax 67s javascript-common libblas3 libcairo2 libdatrie1 libdeflate0 libfontconfig1 67s libgfortran5 libgomp1 libgraphite2-3 libharfbuzz0b libice6 libjbig0 67s libjpeg-turbo8 libjpeg8 libjs-bootstrap libjs-bootstrap4 libjs-d3 67s libjs-es5-shim libjs-highlight.js libjs-jquery libjs-jquery-datatables 67s libjs-jquery-selectize.js libjs-jquery-ui libjs-json libjs-mathjax 67s libjs-microplugin.js libjs-modernizr libjs-popper.js libjs-prettify 67s libjs-sifter.js libjs-twitter-bootstrap-datepicker liblapack3 liblerc4 67s liblua5.4-0 libpango-1.0-0 libpangocairo-1.0-0 libpangoft2-1.0-0 67s libpaper-utils libpaper2 libpixman-1-0 libsharpyuv0 libsm6 libtcl8.6 67s libthai-data libthai0 libtiff6 libtk8.6 libwebp7 libxcb-render0 libxcb-shm0 67s libxft2 libxrender1 libxss1 libxt6t64 littler node-bootstrap-sass 67s node-html5shiv node-normalize.css pandoc pandoc-data r-base-core 67s r-cran-base64enc r-cran-brio r-cran-bslib r-cran-cachem r-cran-callr 67s r-cran-cli r-cran-codetools r-cran-colorspace r-cran-commonmark 67s r-cran-crayon r-cran-desc r-cran-diffobj r-cran-digest r-cran-dosefinding 67s r-cran-evaluate r-cran-fansi r-cran-farver r-cran-fastmap r-cran-fontawesome 67s r-cran-fs r-cran-ggplot2 r-cran-glue r-cran-gtable r-cran-highr 67s r-cran-htmltools r-cran-httpuv r-cran-isoband r-cran-jquerylib 67s r-cran-jsonlite r-cran-knitr r-cran-labeling r-cran-later r-cran-lattice 67s r-cran-lifecycle r-cran-littler r-cran-magrittr r-cran-mass r-cran-matrix 67s r-cran-memoise r-cran-mgcv r-cran-mime r-cran-multcomp r-cran-munsell 67s r-cran-mvtnorm r-cran-nlme r-cran-numderiv r-cran-pillar r-cran-pkgbuild 67s r-cran-pkgconfig r-cran-pkgkitten r-cran-pkgload r-cran-praise 67s r-cran-processx r-cran-promises r-cran-ps r-cran-quadprog r-cran-r6 67s r-cran-rappdirs r-cran-rcolorbrewer r-cran-rcpp r-cran-rlang 67s r-cran-rmarkdown r-cran-rprojroot r-cran-rsolnp r-cran-sandwich r-cran-sass 67s r-cran-scales r-cran-shiny r-cran-sourcetools r-cran-survival 67s r-cran-testthat r-cran-th.data r-cran-tibble r-cran-tinytex r-cran-truncnorm 67s r-cran-utf8 r-cran-vctrs r-cran-viridislite r-cran-waldo r-cran-withr 67s r-cran-xfun r-cran-xtable r-cran-yaml r-cran-zoo unzip x11-common xdg-utils 67s zip 67s 0 upgraded, 156 newly installed, 0 to remove and 0 not upgraded. 67s Need to get 156 MB of archives. 67s After this operation, 481 MB of additional disk space will be used. 67s Get:1 http://ftpmaster.internal/ubuntu plucky/main amd64 fonts-dejavu-mono all 2.37-8 [502 kB] 67s Get:2 http://ftpmaster.internal/ubuntu plucky/main amd64 fonts-dejavu-core all 2.37-8 [835 kB] 67s Get:3 http://ftpmaster.internal/ubuntu plucky/main amd64 fontconfig-config amd64 2.15.0-2ubuntu1 [37.4 kB] 67s Get:4 http://ftpmaster.internal/ubuntu plucky/main amd64 libfontconfig1 amd64 2.15.0-2ubuntu1 [164 kB] 67s Get:5 http://ftpmaster.internal/ubuntu plucky/main amd64 fontconfig amd64 2.15.0-2ubuntu1 [180 kB] 67s Get:6 http://ftpmaster.internal/ubuntu plucky/main amd64 fonts-font-awesome all 5.0.10+really4.7.0~dfsg-4.1 [516 kB] 67s Get:7 http://ftpmaster.internal/ubuntu plucky/universe amd64 fonts-glyphicons-halflings all 1.009~3.4.1+dfsg-3 [118 kB] 67s Get:8 http://ftpmaster.internal/ubuntu plucky/main amd64 fonts-mathjax all 2.7.9+dfsg-1 [2208 kB] 67s Get:9 http://ftpmaster.internal/ubuntu plucky/main amd64 javascript-common all 12 [5216 B] 67s Get:10 http://ftpmaster.internal/ubuntu plucky/main amd64 libblas3 amd64 3.12.1-2 [359 kB] 67s Get:11 http://ftpmaster.internal/ubuntu plucky/main amd64 libpixman-1-0 amd64 0.44.0-3 [427 kB] 67s Get:12 http://ftpmaster.internal/ubuntu plucky/main amd64 libxcb-render0 amd64 1.17.0-2 [16.2 kB] 67s Get:13 http://ftpmaster.internal/ubuntu plucky/main amd64 libxcb-shm0 amd64 1.17.0-2 [5758 B] 67s Get:14 http://ftpmaster.internal/ubuntu plucky/main amd64 libxrender1 amd64 1:0.9.10-1.1build1 [19.0 kB] 67s Get:15 http://ftpmaster.internal/ubuntu plucky/main amd64 libcairo2 amd64 1.18.2-2 [569 kB] 67s Get:16 http://ftpmaster.internal/ubuntu plucky/main amd64 libdatrie1 amd64 0.2.13-3build1 [19.0 kB] 67s Get:17 http://ftpmaster.internal/ubuntu plucky/main amd64 libdeflate0 amd64 1.23-1 [64.1 kB] 67s Get:18 http://ftpmaster.internal/ubuntu plucky/main amd64 libgfortran5 amd64 15-20250213-1ubuntu1 [920 kB] 67s Get:19 http://ftpmaster.internal/ubuntu plucky/main amd64 libgomp1 amd64 15-20250213-1ubuntu1 [148 kB] 67s Get:20 http://ftpmaster.internal/ubuntu plucky/main amd64 libgraphite2-3 amd64 1.3.14-2ubuntu1 [73.1 kB] 67s Get:21 http://ftpmaster.internal/ubuntu plucky/main amd64 libharfbuzz0b amd64 10.2.0-1 [543 kB] 67s Get:22 http://ftpmaster.internal/ubuntu plucky/main amd64 x11-common all 1:7.7+23ubuntu3 [21.7 kB] 67s Get:23 http://ftpmaster.internal/ubuntu plucky/main amd64 libice6 amd64 2:1.1.1-1 [44.1 kB] 67s Get:24 http://ftpmaster.internal/ubuntu plucky/main amd64 libjpeg-turbo8 amd64 2.1.5-3ubuntu2 [179 kB] 67s Get:25 http://ftpmaster.internal/ubuntu plucky/main amd64 libjpeg8 amd64 8c-2ubuntu11 [2148 B] 67s Get:26 http://ftpmaster.internal/ubuntu plucky/universe amd64 libjs-bootstrap all 3.4.1+dfsg-3 [129 kB] 67s Get:27 http://ftpmaster.internal/ubuntu plucky/universe amd64 libjs-popper.js all 1.16.1+ds-6 [54.1 kB] 67s Get:28 http://ftpmaster.internal/ubuntu plucky/universe amd64 libjs-bootstrap4 all 4.6.1+dfsg1-4 [537 kB] 67s Get:29 http://ftpmaster.internal/ubuntu plucky/universe amd64 libjs-d3 all 3.5.17-4 [132 kB] 67s Get:30 http://ftpmaster.internal/ubuntu plucky/universe amd64 libjs-es5-shim all 4.6.7-2 [39.8 kB] 67s Get:31 http://ftpmaster.internal/ubuntu plucky/universe amd64 libjs-highlight.js all 9.18.5+dfsg1-2 [385 kB] 67s Get:32 http://ftpmaster.internal/ubuntu plucky/main amd64 libjs-jquery all 3.6.1+dfsg+~3.5.14-1 [328 kB] 67s Get:33 http://ftpmaster.internal/ubuntu plucky/universe amd64 libjs-jquery-datatables all 1.11.5+dfsg-2 [146 kB] 67s Get:34 http://ftpmaster.internal/ubuntu plucky/universe amd64 libjs-sifter.js all 0.6.0+dfsg-3 [12.6 kB] 67s Get:35 http://ftpmaster.internal/ubuntu plucky/universe amd64 libjs-microplugin.js all 0.0.3+dfsg-1.1 [3712 B] 67s Get:36 http://ftpmaster.internal/ubuntu plucky/universe amd64 libjs-jquery-selectize.js all 0.12.6+dfsg-1.1 [51.0 kB] 67s Get:37 http://ftpmaster.internal/ubuntu plucky/universe amd64 libjs-jquery-ui all 1.13.2+dfsg-1 [252 kB] 67s Get:38 http://ftpmaster.internal/ubuntu plucky/universe amd64 libjs-json all 0~20221030+~1.0.8-1 [20.6 kB] 67s Get:39 http://ftpmaster.internal/ubuntu plucky/universe amd64 libjs-prettify all 2015.12.04+dfsg-1.1 [39.3 kB] 67s Get:40 http://ftpmaster.internal/ubuntu plucky/main amd64 liblapack3 amd64 3.12.1-2 [3179 kB] 67s Get:41 http://ftpmaster.internal/ubuntu plucky/main amd64 liblerc4 amd64 4.0.0+ds-5ubuntu1 [271 kB] 67s Get:42 http://ftpmaster.internal/ubuntu plucky/main amd64 liblua5.4-0 amd64 5.4.7-1 [196 kB] 67s Get:43 http://ftpmaster.internal/ubuntu plucky/main amd64 libthai-data all 0.1.29-2build1 [158 kB] 67s Get:44 http://ftpmaster.internal/ubuntu plucky/main amd64 libthai0 amd64 0.1.29-2build1 [18.9 kB] 67s Get:45 http://ftpmaster.internal/ubuntu plucky/main amd64 libpango-1.0-0 amd64 1.56.1-1 [255 kB] 67s Get:46 http://ftpmaster.internal/ubuntu plucky/main amd64 libpangoft2-1.0-0 amd64 1.56.1-1 [52.6 kB] 67s Get:47 http://ftpmaster.internal/ubuntu plucky/main amd64 libpangocairo-1.0-0 amd64 1.56.1-1 [29.1 kB] 67s Get:48 http://ftpmaster.internal/ubuntu plucky/main amd64 libpaper2 amd64 2.2.5-0.3 [17.4 kB] 67s Get:49 http://ftpmaster.internal/ubuntu plucky/main amd64 libpaper-utils amd64 2.2.5-0.3 [15.5 kB] 67s Get:50 http://ftpmaster.internal/ubuntu plucky/main amd64 libsharpyuv0 amd64 1.5.0-0.1 [25.9 kB] 67s Get:51 http://ftpmaster.internal/ubuntu plucky/main amd64 libsm6 amd64 2:1.2.4-1 [17.4 kB] 67s Get:52 http://ftpmaster.internal/ubuntu plucky/main amd64 libtcl8.6 amd64 8.6.16+dfsg-1 [1086 kB] 67s Get:53 http://ftpmaster.internal/ubuntu plucky/main amd64 libjbig0 amd64 2.1-6.1ubuntu2 [29.7 kB] 67s Get:54 http://ftpmaster.internal/ubuntu plucky/main amd64 libwebp7 amd64 1.5.0-0.1 [378 kB] 67s Get:55 http://ftpmaster.internal/ubuntu plucky/main amd64 libtiff6 amd64 4.5.1+git230720-4ubuntu4 [200 kB] 67s Get:56 http://ftpmaster.internal/ubuntu plucky/main amd64 libxft2 amd64 2.3.6-1build1 [45.3 kB] 67s Get:57 http://ftpmaster.internal/ubuntu plucky/main amd64 libxss1 amd64 1:1.2.3-1build3 [7204 B] 67s Get:58 http://ftpmaster.internal/ubuntu plucky/main amd64 libtk8.6 amd64 8.6.16-1 [868 kB] 67s Get:59 http://ftpmaster.internal/ubuntu plucky/main amd64 libxt6t64 amd64 1:1.2.1-1.2build1 [171 kB] 67s Get:60 http://ftpmaster.internal/ubuntu plucky/main amd64 zip amd64 3.0-14ubuntu2 [185 kB] 67s Get:61 http://ftpmaster.internal/ubuntu plucky/main amd64 unzip amd64 6.0-28ubuntu6 [181 kB] 67s Get:62 http://ftpmaster.internal/ubuntu plucky/main amd64 xdg-utils all 1.2.1-2ubuntu1 [66.0 kB] 67s Get:63 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-base-core amd64 4.4.2-1build1 [28.9 MB] 68s Get:64 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-littler amd64 0.3.20-2 [96.6 kB] 68s Get:65 http://ftpmaster.internal/ubuntu plucky/universe amd64 littler all 0.3.20-2 [2554 B] 68s Get:66 http://ftpmaster.internal/ubuntu plucky/universe amd64 node-bootstrap-sass all 3.4.3-2 [187 kB] 68s Get:67 http://ftpmaster.internal/ubuntu plucky/universe amd64 node-html5shiv all 3.7.3+dfsg-5 [13.5 kB] 68s Get:68 http://ftpmaster.internal/ubuntu plucky/universe amd64 node-normalize.css all 8.0.1-5 [10.8 kB] 68s Get:69 http://ftpmaster.internal/ubuntu plucky/universe amd64 pandoc-data all 3.1.11.1-3build1 [78.8 kB] 68s Get:70 http://ftpmaster.internal/ubuntu plucky/universe amd64 pandoc amd64 3.1.11.1+ds-2 [27.2 MB] 68s Get:71 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-base64enc amd64 0.1-3-3 [27.6 kB] 68s Get:72 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-brio amd64 1.1.5-1 [39.0 kB] 68s Get:73 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-rlang amd64 1.1.5-1 [1719 kB] 68s Get:74 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-fastmap amd64 1.2.0-1 [73.8 kB] 68s Get:75 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-cachem amd64 1.1.0-1 [74.1 kB] 68s Get:76 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-digest amd64 0.6.37-1 [200 kB] 68s Get:77 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-htmltools amd64 0.5.8.1-1 [373 kB] 69s Get:78 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-jquerylib all 0.1.4+dfsg-4 [13.5 kB] 69s Get:79 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-jsonlite amd64 1.8.9+dfsg-1 [445 kB] 69s Get:80 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-cli amd64 3.6.3-1 [1348 kB] 69s Get:81 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-glue amd64 1.8.0-1 [164 kB] 69s Get:82 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-lifecycle all 1.0.4+dfsg-1 [110 kB] 69s Get:83 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-memoise all 2.0.1-1 [53.9 kB] 69s Get:84 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-mime amd64 0.12-2 [35.8 kB] 69s Get:85 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-fs amd64 1.6.5+dfsg-1 [246 kB] 69s Get:86 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-r6 all 2.5.1-1 [99.0 kB] 69s Get:87 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-rappdirs amd64 0.3.3-1 [47.5 kB] 69s Get:88 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-sass amd64 0.4.9+dfsg-1 [1001 kB] 69s Get:89 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-bslib all 0.8.0+dfsg-1 [4294 kB] 69s Get:90 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-ps amd64 1.8.1-1 [397 kB] 69s Get:91 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-processx amd64 3.8.5-1 [356 kB] 69s Get:92 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-callr all 3.7.6-1 [458 kB] 69s Get:93 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-codetools all 0.2-20-1 [90.5 kB] 69s Get:94 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-colorspace amd64 2.1-1+dfsg-1 [1563 kB] 69s Get:95 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-commonmark amd64 1.9.2-2 [137 kB] 69s Get:96 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-crayon all 1.5.3-1 [165 kB] 69s Get:97 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-desc all 1.4.3-1 [359 kB] 69s Get:98 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-diffobj amd64 0.3.5-1 [1117 kB] 69s Get:99 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-gtable all 0.3.6+dfsg-1 [199 kB] 69s Get:100 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-isoband amd64 0.2.7-1 [1481 kB] 69s Get:101 http://ftpmaster.internal/ubuntu plucky-proposed/universe amd64 r-cran-mass amd64 7.3-65-1 [1116 kB] 69s Get:102 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-lattice amd64 0.22-6-1 [1340 kB] 69s Get:103 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-nlme amd64 3.1.167-1 [2320 kB] 69s Get:104 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-matrix amd64 1.7-2-1 [4456 kB] 69s Get:105 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-mgcv amd64 1.9-1-1 [3252 kB] 69s Get:106 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-farver amd64 2.1.2-1 [1355 kB] 69s Get:107 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-labeling all 0.4.3-1 [62.1 kB] 69s Get:108 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-munsell all 0.5.1-1 [213 kB] 69s Get:109 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-rcolorbrewer all 1.1-3-1build1 [55.4 kB] 69s Get:110 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-viridislite all 0.4.2-2 [1088 kB] 69s Get:111 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-scales all 1.3.0-1 [603 kB] 69s Get:112 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-fansi amd64 1.0.5-1 [619 kB] 70s Get:113 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-magrittr amd64 2.0.3-1 [154 kB] 70s Get:114 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-utf8 amd64 1.2.4-1 [140 kB] 70s Get:115 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-vctrs amd64 0.6.5-1 [1335 kB] 70s Get:116 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-pillar all 1.10.1+dfsg-1 [453 kB] 70s Get:117 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-pkgconfig all 2.0.3-2build1 [19.7 kB] 70s Get:118 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-tibble amd64 3.2.1+dfsg-3 [419 kB] 70s Get:119 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-withr all 3.0.2+dfsg-1 [214 kB] 70s Get:120 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-ggplot2 all 3.5.1+dfsg-1 [3940 kB] 70s Get:121 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-mvtnorm amd64 1.3-3-1 [923 kB] 70s Get:122 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-dosefinding amd64 1.2-1-1 [947 kB] 70s Get:123 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-evaluate all 1.0.3-1 [114 kB] 70s Get:124 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-fontawesome all 0.5.3-1 [1331 kB] 70s Get:125 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-xfun amd64 0.50+dfsg-1 [568 kB] 70s Get:126 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-highr all 0.11+dfsg-1 [38.5 kB] 70s Get:127 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-pkgkitten all 0.2.4-1 [27.2 kB] 70s Get:128 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-rcpp amd64 1.0.14-1 [1998 kB] 70s Get:129 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-later amd64 1.4.1+dfsg-1 [154 kB] 70s Get:130 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-promises amd64 1.3.2+dfsg-1 [291 kB] 70s Get:131 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-httpuv amd64 1.6.15+dfsg-1 [510 kB] 70s Get:132 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-yaml amd64 2.3.10-1 [109 kB] 70s Get:133 http://ftpmaster.internal/ubuntu plucky/main amd64 libjs-mathjax all 2.7.9+dfsg-1 [5665 kB] 70s Get:134 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-knitr all 1.49+dfsg-1 [859 kB] 70s Get:135 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-survival amd64 3.8-3-1 [8239 kB] 70s Get:136 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-th.data all 1.1-3-1 [8723 kB] 70s Get:137 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-zoo amd64 1.8-12-2 [984 kB] 70s Get:138 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-sandwich all 3.1-1-1 [1483 kB] 70s Get:139 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-multcomp all 1.4-28-1 [700 kB] 70s Get:140 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-numderiv all 2016.8-1.1-3 [115 kB] 70s Get:141 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-pkgbuild all 1.4.6-1 [213 kB] 70s Get:142 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-rprojroot all 2.0.4-2 [125 kB] 70s Get:143 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-pkgload all 1.4.0-1 [247 kB] 70s Get:144 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-praise all 1.0.0-4build1 [20.3 kB] 70s Get:145 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-quadprog amd64 1.5-8-1build1 [30.9 kB] 70s Get:146 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-tinytex all 0.54-1 [147 kB] 70s Get:147 http://ftpmaster.internal/ubuntu plucky/universe amd64 libjs-modernizr all 3.13.0-0.1 [101 kB] 70s Get:148 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-xtable all 1:1.8-4-2 [689 kB] 70s Get:149 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-sourcetools amd64 0.1.7-1-1 [48.1 kB] 70s Get:150 http://ftpmaster.internal/ubuntu plucky/universe amd64 libjs-twitter-bootstrap-datepicker all 1.3.1+dfsg1-4.1 [28.5 kB] 70s Get:151 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-shiny all 1.10.0+dfsg-2 [3124 kB] 70s Get:152 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-rmarkdown all 2.29+dfsg-1 [1501 kB] 70s Get:153 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-truncnorm amd64 1.0-9-2 [25.3 kB] 70s Get:154 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-rsolnp all 1.16+dfsg-4build1 [249 kB] 70s Get:155 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-waldo all 0.6.1-2 [150 kB] 70s Get:156 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-cran-testthat amd64 3.2.1.1-1 [1636 kB] 71s Preconfiguring packages ... 71s Fetched 156 MB in 3s (46.2 MB/s) 71s Selecting previously unselected package fonts-dejavu-mono. 71s (Reading database ... (Reading database ... 5% (Reading database ... 10% (Reading database ... 15% (Reading database ... 20% (Reading database ... 25% (Reading database ... 30% (Reading database ... 35% (Reading database ... 40% (Reading database ... 45% (Reading database ... 50% (Reading database ... 55% (Reading database ... 60% (Reading database ... 65% (Reading database ... 70% (Reading database ... 75% (Reading database ... 80% (Reading database ... 85% (Reading database ... 90% (Reading database ... 95% (Reading database ... 100% (Reading database ... 109140 files and directories currently installed.) 71s Preparing to unpack .../000-fonts-dejavu-mono_2.37-8_all.deb ... 71s Unpacking fonts-dejavu-mono (2.37-8) ... 71s Selecting previously unselected package fonts-dejavu-core. 71s Preparing to unpack .../001-fonts-dejavu-core_2.37-8_all.deb ... 71s Unpacking fonts-dejavu-core (2.37-8) ... 72s Selecting previously unselected package fontconfig-config. 72s Preparing to unpack .../002-fontconfig-config_2.15.0-2ubuntu1_amd64.deb ... 72s Unpacking fontconfig-config (2.15.0-2ubuntu1) ... 72s Selecting previously unselected package libfontconfig1:amd64. 72s Preparing to unpack .../003-libfontconfig1_2.15.0-2ubuntu1_amd64.deb ... 72s Unpacking libfontconfig1:amd64 (2.15.0-2ubuntu1) ... 72s Selecting previously unselected package fontconfig. 72s Preparing to unpack .../004-fontconfig_2.15.0-2ubuntu1_amd64.deb ... 72s Unpacking fontconfig (2.15.0-2ubuntu1) ... 72s Selecting previously unselected package fonts-font-awesome. 72s Preparing to unpack .../005-fonts-font-awesome_5.0.10+really4.7.0~dfsg-4.1_all.deb ... 72s Unpacking fonts-font-awesome (5.0.10+really4.7.0~dfsg-4.1) ... 72s Selecting previously unselected package fonts-glyphicons-halflings. 72s Preparing to unpack .../006-fonts-glyphicons-halflings_1.009~3.4.1+dfsg-3_all.deb ... 72s Unpacking fonts-glyphicons-halflings (1.009~3.4.1+dfsg-3) ... 72s Selecting previously unselected package fonts-mathjax. 72s Preparing to unpack .../007-fonts-mathjax_2.7.9+dfsg-1_all.deb ... 72s Unpacking fonts-mathjax (2.7.9+dfsg-1) ... 72s Selecting previously unselected package javascript-common. 72s Preparing to unpack .../008-javascript-common_12_all.deb ... 72s Unpacking javascript-common (12) ... 72s Selecting previously unselected package libblas3:amd64. 72s Preparing to unpack .../009-libblas3_3.12.1-2_amd64.deb ... 72s Unpacking libblas3:amd64 (3.12.1-2) ... 72s Selecting previously unselected package libpixman-1-0:amd64. 72s Preparing to unpack .../010-libpixman-1-0_0.44.0-3_amd64.deb ... 72s Unpacking libpixman-1-0:amd64 (0.44.0-3) ... 72s Selecting previously unselected package libxcb-render0:amd64. 72s Preparing to unpack .../011-libxcb-render0_1.17.0-2_amd64.deb ... 72s Unpacking libxcb-render0:amd64 (1.17.0-2) ... 72s Selecting previously unselected package libxcb-shm0:amd64. 72s Preparing to unpack .../012-libxcb-shm0_1.17.0-2_amd64.deb ... 72s Unpacking libxcb-shm0:amd64 (1.17.0-2) ... 72s Selecting previously unselected package libxrender1:amd64. 72s Preparing to unpack .../013-libxrender1_1%3a0.9.10-1.1build1_amd64.deb ... 72s Unpacking libxrender1:amd64 (1:0.9.10-1.1build1) ... 72s Selecting previously unselected package libcairo2:amd64. 72s Preparing to unpack .../014-libcairo2_1.18.2-2_amd64.deb ... 72s Unpacking libcairo2:amd64 (1.18.2-2) ... 72s Selecting previously unselected package libdatrie1:amd64. 73s Preparing to unpack .../015-libdatrie1_0.2.13-3build1_amd64.deb ... 73s Unpacking libdatrie1:amd64 (0.2.13-3build1) ... 73s Selecting previously unselected package libdeflate0:amd64. 73s Preparing to unpack .../016-libdeflate0_1.23-1_amd64.deb ... 73s Unpacking libdeflate0:amd64 (1.23-1) ... 73s Selecting previously unselected package libgfortran5:amd64. 73s Preparing to unpack .../017-libgfortran5_15-20250213-1ubuntu1_amd64.deb ... 73s Unpacking libgfortran5:amd64 (15-20250213-1ubuntu1) ... 73s Selecting previously unselected package libgomp1:amd64. 73s Preparing to unpack .../018-libgomp1_15-20250213-1ubuntu1_amd64.deb ... 73s Unpacking libgomp1:amd64 (15-20250213-1ubuntu1) ... 73s Selecting previously unselected package libgraphite2-3:amd64. 73s Preparing to unpack .../019-libgraphite2-3_1.3.14-2ubuntu1_amd64.deb ... 73s Unpacking libgraphite2-3:amd64 (1.3.14-2ubuntu1) ... 73s Selecting previously unselected package libharfbuzz0b:amd64. 73s Preparing to unpack .../020-libharfbuzz0b_10.2.0-1_amd64.deb ... 73s Unpacking libharfbuzz0b:amd64 (10.2.0-1) ... 73s Selecting previously unselected package x11-common. 73s Preparing to unpack .../021-x11-common_1%3a7.7+23ubuntu3_all.deb ... 73s Unpacking x11-common (1:7.7+23ubuntu3) ... 73s Selecting previously unselected package libice6:amd64. 73s Preparing to unpack .../022-libice6_2%3a1.1.1-1_amd64.deb ... 73s Unpacking libice6:amd64 (2:1.1.1-1) ... 73s Selecting previously unselected package libjpeg-turbo8:amd64. 73s Preparing to unpack .../023-libjpeg-turbo8_2.1.5-3ubuntu2_amd64.deb ... 73s Unpacking libjpeg-turbo8:amd64 (2.1.5-3ubuntu2) ... 73s Selecting previously unselected package libjpeg8:amd64. 73s Preparing to unpack .../024-libjpeg8_8c-2ubuntu11_amd64.deb ... 73s Unpacking libjpeg8:amd64 (8c-2ubuntu11) ... 73s Selecting previously unselected package libjs-bootstrap. 73s Preparing to unpack .../025-libjs-bootstrap_3.4.1+dfsg-3_all.deb ... 73s Unpacking libjs-bootstrap (3.4.1+dfsg-3) ... 73s Selecting previously unselected package libjs-popper.js. 73s Preparing to unpack .../026-libjs-popper.js_1.16.1+ds-6_all.deb ... 73s Unpacking libjs-popper.js (1.16.1+ds-6) ... 73s Selecting previously unselected package libjs-bootstrap4. 73s Preparing to unpack .../027-libjs-bootstrap4_4.6.1+dfsg1-4_all.deb ... 73s Unpacking libjs-bootstrap4 (4.6.1+dfsg1-4) ... 73s Selecting previously unselected package libjs-d3. 73s Preparing to unpack .../028-libjs-d3_3.5.17-4_all.deb ... 73s Unpacking libjs-d3 (3.5.17-4) ... 73s Selecting previously unselected package libjs-es5-shim. 73s Preparing to unpack .../029-libjs-es5-shim_4.6.7-2_all.deb ... 73s Unpacking libjs-es5-shim (4.6.7-2) ... 73s Selecting previously unselected package libjs-highlight.js. 73s Preparing to unpack .../030-libjs-highlight.js_9.18.5+dfsg1-2_all.deb ... 73s Unpacking libjs-highlight.js (9.18.5+dfsg1-2) ... 73s Selecting previously unselected package libjs-jquery. 73s Preparing to unpack .../031-libjs-jquery_3.6.1+dfsg+~3.5.14-1_all.deb ... 73s Unpacking libjs-jquery (3.6.1+dfsg+~3.5.14-1) ... 73s Selecting previously unselected package libjs-jquery-datatables. 73s Preparing to unpack .../032-libjs-jquery-datatables_1.11.5+dfsg-2_all.deb ... 73s Unpacking libjs-jquery-datatables (1.11.5+dfsg-2) ... 73s Selecting previously unselected package libjs-sifter.js. 73s Preparing to unpack .../033-libjs-sifter.js_0.6.0+dfsg-3_all.deb ... 73s Unpacking libjs-sifter.js (0.6.0+dfsg-3) ... 74s Selecting previously unselected package libjs-microplugin.js. 74s Preparing to unpack .../034-libjs-microplugin.js_0.0.3+dfsg-1.1_all.deb ... 74s Unpacking libjs-microplugin.js (0.0.3+dfsg-1.1) ... 74s Selecting previously unselected package libjs-jquery-selectize.js. 74s Preparing to unpack .../035-libjs-jquery-selectize.js_0.12.6+dfsg-1.1_all.deb ... 74s Unpacking libjs-jquery-selectize.js (0.12.6+dfsg-1.1) ... 74s Selecting previously unselected package libjs-jquery-ui. 74s Preparing to unpack .../036-libjs-jquery-ui_1.13.2+dfsg-1_all.deb ... 74s Unpacking libjs-jquery-ui (1.13.2+dfsg-1) ... 74s Selecting previously unselected package libjs-json. 74s Preparing to unpack .../037-libjs-json_0~20221030+~1.0.8-1_all.deb ... 74s Unpacking libjs-json (0~20221030+~1.0.8-1) ... 74s Selecting previously unselected package libjs-prettify. 74s Preparing to unpack .../038-libjs-prettify_2015.12.04+dfsg-1.1_all.deb ... 74s Unpacking libjs-prettify (2015.12.04+dfsg-1.1) ... 74s Selecting previously unselected package liblapack3:amd64. 74s Preparing to unpack .../039-liblapack3_3.12.1-2_amd64.deb ... 74s Unpacking liblapack3:amd64 (3.12.1-2) ... 74s Selecting previously unselected package liblerc4:amd64. 74s Preparing to unpack .../040-liblerc4_4.0.0+ds-5ubuntu1_amd64.deb ... 74s Unpacking liblerc4:amd64 (4.0.0+ds-5ubuntu1) ... 74s Selecting previously unselected package liblua5.4-0:amd64. 74s Preparing to unpack .../041-liblua5.4-0_5.4.7-1_amd64.deb ... 74s Unpacking liblua5.4-0:amd64 (5.4.7-1) ... 74s Selecting previously unselected package libthai-data. 74s Preparing to unpack .../042-libthai-data_0.1.29-2build1_all.deb ... 74s Unpacking libthai-data (0.1.29-2build1) ... 74s Selecting previously unselected package libthai0:amd64. 74s Preparing to unpack .../043-libthai0_0.1.29-2build1_amd64.deb ... 74s Unpacking libthai0:amd64 (0.1.29-2build1) ... 74s Selecting previously unselected package libpango-1.0-0:amd64. 74s Preparing to unpack .../044-libpango-1.0-0_1.56.1-1_amd64.deb ... 74s Unpacking libpango-1.0-0:amd64 (1.56.1-1) ... 74s Selecting previously unselected package libpangoft2-1.0-0:amd64. 74s Preparing to unpack .../045-libpangoft2-1.0-0_1.56.1-1_amd64.deb ... 74s Unpacking libpangoft2-1.0-0:amd64 (1.56.1-1) ... 74s Selecting previously unselected package libpangocairo-1.0-0:amd64. 74s Preparing to unpack .../046-libpangocairo-1.0-0_1.56.1-1_amd64.deb ... 74s Unpacking libpangocairo-1.0-0:amd64 (1.56.1-1) ... 74s Selecting previously unselected package libpaper2:amd64. 74s Preparing to unpack .../047-libpaper2_2.2.5-0.3_amd64.deb ... 74s Unpacking libpaper2:amd64 (2.2.5-0.3) ... 74s Selecting previously unselected package libpaper-utils. 74s Preparing to unpack .../048-libpaper-utils_2.2.5-0.3_amd64.deb ... 74s Unpacking libpaper-utils (2.2.5-0.3) ... 74s Selecting previously unselected package libsharpyuv0:amd64. 74s Preparing to unpack .../049-libsharpyuv0_1.5.0-0.1_amd64.deb ... 74s Unpacking libsharpyuv0:amd64 (1.5.0-0.1) ... 74s Selecting previously unselected package libsm6:amd64. 74s Preparing to unpack .../050-libsm6_2%3a1.2.4-1_amd64.deb ... 74s Unpacking libsm6:amd64 (2:1.2.4-1) ... 74s Selecting previously unselected package libtcl8.6:amd64. 74s Preparing to unpack .../051-libtcl8.6_8.6.16+dfsg-1_amd64.deb ... 74s Unpacking libtcl8.6:amd64 (8.6.16+dfsg-1) ... 75s Selecting previously unselected package libjbig0:amd64. 75s Preparing to unpack .../052-libjbig0_2.1-6.1ubuntu2_amd64.deb ... 75s Unpacking libjbig0:amd64 (2.1-6.1ubuntu2) ... 75s Selecting previously unselected package libwebp7:amd64. 75s Preparing to unpack .../053-libwebp7_1.5.0-0.1_amd64.deb ... 75s Unpacking libwebp7:amd64 (1.5.0-0.1) ... 75s Selecting previously unselected package libtiff6:amd64. 75s Preparing to unpack .../054-libtiff6_4.5.1+git230720-4ubuntu4_amd64.deb ... 75s Unpacking libtiff6:amd64 (4.5.1+git230720-4ubuntu4) ... 75s Selecting previously unselected package libxft2:amd64. 75s Preparing to unpack .../055-libxft2_2.3.6-1build1_amd64.deb ... 75s Unpacking libxft2:amd64 (2.3.6-1build1) ... 75s Selecting previously unselected package libxss1:amd64. 75s Preparing to unpack .../056-libxss1_1%3a1.2.3-1build3_amd64.deb ... 75s Unpacking libxss1:amd64 (1:1.2.3-1build3) ... 75s Selecting previously unselected package libtk8.6:amd64. 75s Preparing to unpack .../057-libtk8.6_8.6.16-1_amd64.deb ... 75s Unpacking libtk8.6:amd64 (8.6.16-1) ... 75s Selecting previously unselected package libxt6t64:amd64. 75s Preparing to unpack .../058-libxt6t64_1%3a1.2.1-1.2build1_amd64.deb ... 75s Unpacking libxt6t64:amd64 (1:1.2.1-1.2build1) ... 75s Selecting previously unselected package zip. 75s Preparing to unpack .../059-zip_3.0-14ubuntu2_amd64.deb ... 75s Unpacking zip (3.0-14ubuntu2) ... 75s Selecting previously unselected package unzip. 75s Preparing to unpack .../060-unzip_6.0-28ubuntu6_amd64.deb ... 75s Unpacking unzip (6.0-28ubuntu6) ... 75s Selecting previously unselected package xdg-utils. 75s Preparing to unpack .../061-xdg-utils_1.2.1-2ubuntu1_all.deb ... 75s Unpacking xdg-utils (1.2.1-2ubuntu1) ... 75s Selecting previously unselected package r-base-core. 75s Preparing to unpack .../062-r-base-core_4.4.2-1build1_amd64.deb ... 75s Unpacking r-base-core (4.4.2-1build1) ... 76s Selecting previously unselected package r-cran-littler. 76s Preparing to unpack .../063-r-cran-littler_0.3.20-2_amd64.deb ... 76s Unpacking r-cran-littler (0.3.20-2) ... 76s Selecting previously unselected package littler. 76s Preparing to unpack .../064-littler_0.3.20-2_all.deb ... 76s Unpacking littler (0.3.20-2) ... 76s Selecting previously unselected package node-bootstrap-sass. 76s Preparing to unpack .../065-node-bootstrap-sass_3.4.3-2_all.deb ... 76s Unpacking node-bootstrap-sass (3.4.3-2) ... 76s Selecting previously unselected package node-html5shiv. 76s Preparing to unpack .../066-node-html5shiv_3.7.3+dfsg-5_all.deb ... 76s Unpacking node-html5shiv (3.7.3+dfsg-5) ... 76s Selecting previously unselected package node-normalize.css. 76s Preparing to unpack .../067-node-normalize.css_8.0.1-5_all.deb ... 76s Unpacking node-normalize.css (8.0.1-5) ... 76s Selecting previously unselected package pandoc-data. 76s Preparing to unpack .../068-pandoc-data_3.1.11.1-3build1_all.deb ... 76s Unpacking pandoc-data (3.1.11.1-3build1) ... 76s Selecting previously unselected package pandoc. 76s Preparing to unpack .../069-pandoc_3.1.11.1+ds-2_amd64.deb ... 76s Unpacking pandoc (3.1.11.1+ds-2) ... 77s Selecting previously unselected package r-cran-base64enc. 77s Preparing to unpack .../070-r-cran-base64enc_0.1-3-3_amd64.deb ... 77s Unpacking r-cran-base64enc (0.1-3-3) ... 77s Selecting previously unselected package r-cran-brio. 77s Preparing to unpack .../071-r-cran-brio_1.1.5-1_amd64.deb ... 77s Unpacking r-cran-brio (1.1.5-1) ... 77s Selecting previously unselected package r-cran-rlang. 77s Preparing to unpack .../072-r-cran-rlang_1.1.5-1_amd64.deb ... 77s Unpacking r-cran-rlang (1.1.5-1) ... 77s Selecting previously unselected package r-cran-fastmap. 77s Preparing to unpack .../073-r-cran-fastmap_1.2.0-1_amd64.deb ... 77s Unpacking r-cran-fastmap (1.2.0-1) ... 77s Selecting previously unselected package r-cran-cachem. 77s Preparing to unpack .../074-r-cran-cachem_1.1.0-1_amd64.deb ... 77s Unpacking r-cran-cachem (1.1.0-1) ... 77s Selecting previously unselected package r-cran-digest. 77s Preparing to unpack .../075-r-cran-digest_0.6.37-1_amd64.deb ... 77s Unpacking r-cran-digest (0.6.37-1) ... 77s Selecting previously unselected package r-cran-htmltools. 77s Preparing to unpack .../076-r-cran-htmltools_0.5.8.1-1_amd64.deb ... 77s Unpacking r-cran-htmltools (0.5.8.1-1) ... 77s Selecting previously unselected package r-cran-jquerylib. 77s Preparing to unpack .../077-r-cran-jquerylib_0.1.4+dfsg-4_all.deb ... 77s Unpacking r-cran-jquerylib (0.1.4+dfsg-4) ... 77s Selecting previously unselected package r-cran-jsonlite. 77s Preparing to unpack .../078-r-cran-jsonlite_1.8.9+dfsg-1_amd64.deb ... 77s Unpacking r-cran-jsonlite (1.8.9+dfsg-1) ... 77s Selecting previously unselected package r-cran-cli. 77s Preparing to unpack .../079-r-cran-cli_3.6.3-1_amd64.deb ... 77s Unpacking r-cran-cli (3.6.3-1) ... 78s Selecting previously unselected package r-cran-glue. 78s Preparing to unpack .../080-r-cran-glue_1.8.0-1_amd64.deb ... 78s Unpacking r-cran-glue (1.8.0-1) ... 78s Selecting previously unselected package r-cran-lifecycle. 78s Preparing to unpack .../081-r-cran-lifecycle_1.0.4+dfsg-1_all.deb ... 78s Unpacking r-cran-lifecycle (1.0.4+dfsg-1) ... 78s Selecting previously unselected package r-cran-memoise. 78s Preparing to unpack .../082-r-cran-memoise_2.0.1-1_all.deb ... 78s Unpacking r-cran-memoise (2.0.1-1) ... 78s Selecting previously unselected package r-cran-mime. 78s Preparing to unpack .../083-r-cran-mime_0.12-2_amd64.deb ... 78s Unpacking r-cran-mime (0.12-2) ... 78s Selecting previously unselected package r-cran-fs. 78s Preparing to unpack .../084-r-cran-fs_1.6.5+dfsg-1_amd64.deb ... 78s Unpacking r-cran-fs (1.6.5+dfsg-1) ... 78s Selecting previously unselected package r-cran-r6. 78s Preparing to unpack .../085-r-cran-r6_2.5.1-1_all.deb ... 78s Unpacking r-cran-r6 (2.5.1-1) ... 78s Selecting previously unselected package r-cran-rappdirs. 78s Preparing to unpack .../086-r-cran-rappdirs_0.3.3-1_amd64.deb ... 78s Unpacking r-cran-rappdirs (0.3.3-1) ... 78s Selecting previously unselected package r-cran-sass. 78s Preparing to unpack .../087-r-cran-sass_0.4.9+dfsg-1_amd64.deb ... 78s Unpacking r-cran-sass (0.4.9+dfsg-1) ... 78s Selecting previously unselected package r-cran-bslib. 78s Preparing to unpack .../088-r-cran-bslib_0.8.0+dfsg-1_all.deb ... 78s Unpacking r-cran-bslib (0.8.0+dfsg-1) ... 78s Selecting previously unselected package r-cran-ps. 78s Preparing to unpack .../089-r-cran-ps_1.8.1-1_amd64.deb ... 78s Unpacking r-cran-ps (1.8.1-1) ... 78s Selecting previously unselected package r-cran-processx. 78s Preparing to unpack .../090-r-cran-processx_3.8.5-1_amd64.deb ... 78s Unpacking r-cran-processx (3.8.5-1) ... 78s Selecting previously unselected package r-cran-callr. 78s Preparing to unpack .../091-r-cran-callr_3.7.6-1_all.deb ... 78s Unpacking r-cran-callr (3.7.6-1) ... 78s Selecting previously unselected package r-cran-codetools. 78s Preparing to unpack .../092-r-cran-codetools_0.2-20-1_all.deb ... 78s Unpacking r-cran-codetools (0.2-20-1) ... 78s Selecting previously unselected package r-cran-colorspace. 78s Preparing to unpack .../093-r-cran-colorspace_2.1-1+dfsg-1_amd64.deb ... 78s Unpacking r-cran-colorspace (2.1-1+dfsg-1) ... 79s Selecting previously unselected package r-cran-commonmark. 79s Preparing to unpack .../094-r-cran-commonmark_1.9.2-2_amd64.deb ... 79s Unpacking r-cran-commonmark (1.9.2-2) ... 79s Selecting previously unselected package r-cran-crayon. 79s Preparing to unpack .../095-r-cran-crayon_1.5.3-1_all.deb ... 79s Unpacking r-cran-crayon (1.5.3-1) ... 79s Selecting previously unselected package r-cran-desc. 79s Preparing to unpack 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Preparing to unpack .../102-r-cran-nlme_3.1.167-1_amd64.deb ... 79s Unpacking r-cran-nlme (3.1.167-1) ... 79s Selecting previously unselected package r-cran-matrix. 79s Preparing to unpack .../103-r-cran-matrix_1.7-2-1_amd64.deb ... 79s Unpacking r-cran-matrix (1.7-2-1) ... 79s Selecting previously unselected package r-cran-mgcv. 79s Preparing to unpack .../104-r-cran-mgcv_1.9-1-1_amd64.deb ... 79s Unpacking r-cran-mgcv (1.9-1-1) ... 79s Selecting previously unselected package r-cran-farver. 79s Preparing to unpack .../105-r-cran-farver_2.1.2-1_amd64.deb ... 79s Unpacking r-cran-farver (2.1.2-1) ... 79s Selecting previously unselected package r-cran-labeling. 79s Preparing to unpack .../106-r-cran-labeling_0.4.3-1_all.deb ... 79s Unpacking r-cran-labeling (0.4.3-1) ... 79s Selecting previously unselected package r-cran-munsell. 79s Preparing to unpack .../107-r-cran-munsell_0.5.1-1_all.deb ... 79s Unpacking r-cran-munsell (0.5.1-1) ... 80s Selecting previously unselected package r-cran-rcolorbrewer. 80s Preparing to unpack .../108-r-cran-rcolorbrewer_1.1-3-1build1_all.deb ... 80s Unpacking r-cran-rcolorbrewer (1.1-3-1build1) ... 80s Selecting previously unselected package r-cran-viridislite. 80s Preparing to unpack .../109-r-cran-viridislite_0.4.2-2_all.deb ... 80s Unpacking r-cran-viridislite (0.4.2-2) ... 80s Selecting previously unselected package r-cran-scales. 80s Preparing to unpack .../110-r-cran-scales_1.3.0-1_all.deb ... 80s Unpacking r-cran-scales (1.3.0-1) ... 80s Selecting previously unselected package r-cran-fansi. 80s Preparing to unpack .../111-r-cran-fansi_1.0.5-1_amd64.deb ... 80s Unpacking r-cran-fansi (1.0.5-1) ... 80s Selecting previously unselected package r-cran-magrittr. 80s Preparing to unpack .../112-r-cran-magrittr_2.0.3-1_amd64.deb ... 80s Unpacking r-cran-magrittr (2.0.3-1) ... 80s Selecting previously unselected package r-cran-utf8. 80s Preparing to unpack .../113-r-cran-utf8_1.2.4-1_amd64.deb ... 80s Unpacking r-cran-utf8 (1.2.4-1) ... 80s Selecting previously unselected package r-cran-vctrs. 80s Preparing to unpack .../114-r-cran-vctrs_0.6.5-1_amd64.deb ... 80s Unpacking r-cran-vctrs (0.6.5-1) ... 80s Selecting previously unselected package r-cran-pillar. 80s Preparing to unpack .../115-r-cran-pillar_1.10.1+dfsg-1_all.deb ... 80s Unpacking r-cran-pillar (1.10.1+dfsg-1) ... 80s Selecting previously unselected package r-cran-pkgconfig. 80s Preparing to unpack .../116-r-cran-pkgconfig_2.0.3-2build1_all.deb ... 80s Unpacking r-cran-pkgconfig (2.0.3-2build1) ... 80s Selecting previously unselected package r-cran-tibble. 80s Preparing to unpack .../117-r-cran-tibble_3.2.1+dfsg-3_amd64.deb ... 80s Unpacking r-cran-tibble (3.2.1+dfsg-3) ... 80s Selecting previously unselected package r-cran-withr. 80s Preparing to unpack .../118-r-cran-withr_3.0.2+dfsg-1_all.deb ... 80s Unpacking r-cran-withr (3.0.2+dfsg-1) ... 80s Selecting previously unselected package r-cran-ggplot2. 80s Preparing to unpack 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previously unselected package r-cran-highr. 81s Preparing to unpack .../125-r-cran-highr_0.11+dfsg-1_all.deb ... 81s Unpacking r-cran-highr (0.11+dfsg-1) ... 81s Selecting previously unselected package r-cran-pkgkitten. 81s Preparing to unpack .../126-r-cran-pkgkitten_0.2.4-1_all.deb ... 81s Unpacking r-cran-pkgkitten (0.2.4-1) ... 81s Selecting previously unselected package r-cran-rcpp. 81s Preparing to unpack .../127-r-cran-rcpp_1.0.14-1_amd64.deb ... 81s Unpacking r-cran-rcpp (1.0.14-1) ... 81s Selecting previously unselected package r-cran-later. 81s Preparing to unpack .../128-r-cran-later_1.4.1+dfsg-1_amd64.deb ... 81s Unpacking r-cran-later (1.4.1+dfsg-1) ... 81s Selecting previously unselected package r-cran-promises. 81s Preparing to unpack .../129-r-cran-promises_1.3.2+dfsg-1_amd64.deb ... 81s Unpacking r-cran-promises (1.3.2+dfsg-1) ... 81s Selecting previously unselected package r-cran-httpuv. 81s Preparing to unpack .../130-r-cran-httpuv_1.6.15+dfsg-1_amd64.deb ... 81s Unpacking r-cran-httpuv (1.6.15+dfsg-1) ... 81s Selecting previously unselected package r-cran-yaml. 81s Preparing to unpack .../131-r-cran-yaml_2.3.10-1_amd64.deb ... 81s Unpacking r-cran-yaml (2.3.10-1) ... 81s Selecting previously unselected package libjs-mathjax. 81s Preparing to unpack .../132-libjs-mathjax_2.7.9+dfsg-1_all.deb ... 81s Unpacking libjs-mathjax (2.7.9+dfsg-1) ... 82s Selecting previously unselected package r-cran-knitr. 82s Preparing to unpack .../133-r-cran-knitr_1.49+dfsg-1_all.deb ... 82s Unpacking r-cran-knitr (1.49+dfsg-1) ... 82s Selecting previously unselected package r-cran-survival. 82s Preparing to unpack .../134-r-cran-survival_3.8-3-1_amd64.deb ... 82s Unpacking r-cran-survival (3.8-3-1) ... 82s Selecting previously unselected package r-cran-th.data. 83s Preparing to unpack .../135-r-cran-th.data_1.1-3-1_all.deb ... 83s Unpacking r-cran-th.data (1.1-3-1) ... 83s Selecting previously unselected package r-cran-zoo. 83s Preparing to unpack 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package r-cran-pkgload. 83s Preparing to unpack .../142-r-cran-pkgload_1.4.0-1_all.deb ... 83s Unpacking r-cran-pkgload (1.4.0-1) ... 83s Selecting previously unselected package r-cran-praise. 83s Preparing to unpack .../143-r-cran-praise_1.0.0-4build1_all.deb ... 83s Unpacking r-cran-praise (1.0.0-4build1) ... 83s Selecting previously unselected package r-cran-quadprog. 83s Preparing to unpack .../144-r-cran-quadprog_1.5-8-1build1_amd64.deb ... 83s Unpacking r-cran-quadprog (1.5-8-1build1) ... 83s Selecting previously unselected package r-cran-tinytex. 83s Preparing to unpack .../145-r-cran-tinytex_0.54-1_all.deb ... 83s Unpacking r-cran-tinytex (0.54-1) ... 83s Selecting previously unselected package libjs-modernizr. 83s Preparing to unpack .../146-libjs-modernizr_3.13.0-0.1_all.deb ... 83s Unpacking libjs-modernizr (3.13.0-0.1) ... 83s Selecting previously unselected package r-cran-xtable. 83s Preparing to unpack .../147-r-cran-xtable_1%3a1.8-4-2_all.deb ... 83s Unpacking r-cran-xtable (1:1.8-4-2) ... 83s Selecting previously unselected package r-cran-sourcetools. 83s Preparing to unpack .../148-r-cran-sourcetools_0.1.7-1-1_amd64.deb ... 83s Unpacking r-cran-sourcetools (0.1.7-1-1) ... 83s Selecting previously unselected package libjs-twitter-bootstrap-datepicker. 83s Preparing to unpack .../149-libjs-twitter-bootstrap-datepicker_1.3.1+dfsg1-4.1_all.deb ... 83s Unpacking libjs-twitter-bootstrap-datepicker (1.3.1+dfsg1-4.1) ... 83s Selecting previously unselected package r-cran-shiny. 83s Preparing to unpack .../150-r-cran-shiny_1.10.0+dfsg-2_all.deb ... 83s Unpacking r-cran-shiny (1.10.0+dfsg-2) ... 83s Selecting previously unselected package r-cran-rmarkdown. 84s Preparing to unpack .../151-r-cran-rmarkdown_2.29+dfsg-1_all.deb ... 84s Unpacking r-cran-rmarkdown (2.29+dfsg-1) ... 84s Selecting previously unselected package r-cran-truncnorm. 84s Preparing to unpack .../152-r-cran-truncnorm_1.0-9-2_amd64.deb ... 84s Unpacking r-cran-truncnorm (1.0-9-2) 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Setting up r-cran-memoise (2.0.1-1) ... 87s Setting up r-cran-promises (1.3.2+dfsg-1) ... 87s Setting up r-cran-multcomp (1.4-28-1) ... 87s Setting up r-cran-pkgbuild (1.4.6-1) ... 87s Setting up r-cran-pkgload (1.4.0-1) ... 87s Setting up r-cran-ggplot2 (3.5.1+dfsg-1) ... 87s Setting up r-cran-httpuv (1.6.15+dfsg-1) ... 87s Setting up r-cran-testthat (3.2.1.1-1) ... 87s Setting up r-cran-bslib (0.8.0+dfsg-1) ... 87s Setting up r-cran-dosefinding (1.2-1-1) ... 87s Setting up r-cran-shiny (1.10.0+dfsg-2) ... 87s Setting up r-cran-rmarkdown (2.29+dfsg-1) ... 87s Processing triggers for libc-bin (2.40-4ubuntu1) ... 87s Processing triggers for man-db (2.13.0-1) ... 89s Processing triggers for install-info (7.1.1-1) ... 89s autopkgtest [05:01:03]: test run-unit-test: [----------------------- 90s Loading required package: DoseFinding 91s Dose Response Model 91s 91s Model: linear 91s Fit-type: general 91s 91s Coefficients dose-response model 91s delta 91s 0.07484 91s 91s Fitted to: 91s 1 2 3 4 91s 0.2846 0.2965 0.3502 0.3480 91s 91s Generalized residual sum of squares: 3.472 91s Dose Response Model 91s 91s Model: linear 91s Fit-type: general 91s 91s Coefficients dose-response model 91s e0 delta 91s 0.33400 0.07484 91s 91s Fitted to: 91s 0 1 2 3 4 91s 0.2220 0.5065 0.5185 0.5722 0.5700 91s 91s Generalized residual sum of squares: 3.472 91s Dose Response Model 91s 91s Model: quadratic 91s Fit-type: general 91s 91s Coefficients dose-response model 91s b1 b2 91s 0.22800 -0.03811 91s 91s Fitted to: 91s 1 2 3 4 91s 0.2846 0.2965 0.3502 0.3480 91s 91s Generalized residual sum of squares: 0.9281 91s Dose Response Model 91s 91s Model: quadratic 91s Fit-type: general 91s 91s Coefficients dose-response model 91s e0 b1 b2 91s 0.24950 0.22800 -0.03811 91s 91s Fitted to: 91s 0 1 2 3 4 91s 0.2220 0.5065 0.5185 0.5722 0.5700 91s 91s Generalized residual sum of squares: 0.9281 91s Dose Response Model 91s 91s Model: linlog 91s Fit-type: general 91s 91s Coefficients dose-response model 91s e0 delta 91s 0.47790 0.07728 91s 91s Fitted to: 91s 0 1 2 3 4 91s 0.2220 0.5065 0.5185 0.5722 0.5700 91s 91s Generalized residual sum of squares: 0.1605 91s Dose Response Model 91s 91s Model: emax 91s Fit-type: general 91s 91s Coefficients dose-response model 91s eMax ed50 91s 0.3771 0.3630 91s 91s Fitted to: 91s 1 2 3 4 91s 0.2846 0.2965 0.3502 0.3480 91s 91s Generalized residual sum of squares: 0.09815 91s Dose Response Model 91s 91s Model: emax 91s Fit-type: general 91s 91s Coefficients dose-response model 91s e0 eMax ed50 91s 0.2221 0.3771 0.3630 91s 91s Fitted to: 91s 0 1 2 3 4 91s 0.2220 0.5065 0.5185 0.5722 0.5700 91s 91s Generalized residual sum of squares: 0.09815 91s Dose Response Model 91s 91s Model: sigEmax 91s Fit-type: general 91s 91s Coefficients dose-response model 91s eMax ed50 h 91s 0.4714 0.4880 0.5000 91s 91s Fitted to: 91s 1 2 3 4 91s 0.2846 0.2965 0.3502 0.3480 91s 91s Generalized residual sum of squares: 0.07825 91s Dose Response Model 91s 91s Model: sigEmax 91s Fit-type: general 91s 91s Coefficients dose-response model 91s e0 eMax ed50 h 91s 0.2223 0.4714 0.4880 0.5000 91s 91s Fitted to: 91s 0 1 2 3 4 91s 0.2220 0.5065 0.5185 0.5722 0.5700 91s 91s Generalized residual sum of squares: 0.07825 91s Dose Response Model 91s 91s Model: exponential 91s Fit-type: general 91s 91s Coefficients dose-response model 91s e1 delta 91s 0.4391 8.0000 91s 91s Fitted to: 91s 1 2 3 4 91s 0.2846 0.2965 0.3502 0.3480 91s 91s Generalized residual sum of squares: 4.102 91s Dose Response Model 91s 91s Model: exponential 91s Fit-type: general 91s 91s Coefficients dose-response model 91s e0 e1 delta 91s 0.3510 0.4391 8.0000 91s 91s Fitted to: 91s 0 1 2 3 4 91s 0.2220 0.5065 0.5185 0.5722 0.5700 91s 91s Generalized residual sum of squares: 4.102 91s Dose Response Model 91s 91s Model: logistic 91s Fit-type: general 91s 91s Coefficients dose-response model 91s e0 eMax ed50 delta 91s -0.1095 0.6665 0.0040 0.4217 91s 91s Fitted to: 91s 0 1 2 3 4 91s 0.2220 0.5065 0.5185 0.5722 0.5700 91s 91s Generalized residual sum of squares: 0.1951 91s Dose Response Model 91s 91s Model: betaMod 91s Fit-type: general 91s 91s Coefficients dose-response model 91s eMax delta1 delta2 91s 0.3468 0.2216 0.0500 91s 91s Fitted to: 91s 1 2 3 4 91s 0.2846 0.2965 0.3502 0.3480 91s 91s Generalized residual sum of squares: 0.0783 91s Dose Response Model 91s 91s Model: betaMod 91s Fit-type: general 91s 91s Coefficients dose-response model 91s e0 eMax delta1 delta2 91s 0.2222 0.3468 0.2216 0.0500 91s 91s Fitted to: 91s 0 1 2 3 4 91s 0.2220 0.5065 0.5185 0.5722 0.5700 91s 91s Generalized residual sum of squares: 0.0783 91s Dose Response Model 91s 91s Model: linInt 91s Fit-type: general 91s 91s Coefficients dose-response model 91s d1 d2 d3 d4 91s 0.2846 0.2965 0.3502 0.3480 91s 91s Fitted to: 91s 1 2 3 4 91s 0.2846 0.2965 0.3502 0.3480 91s 91s Generalized residual sum of squares: 0 91s Dose Response Model 91s 91s Model: linInt 91s Fit-type: general 91s 91s Coefficients dose-response model 91s d0 d1 d2 d3 d4 91s 0.2220 0.5065 0.5185 0.5722 0.5700 91s 91s Fitted to: 91s 0 1 2 3 4 91s 0.2220 0.5065 0.5185 0.5722 0.5700 91s 91s Generalized residual sum of squares: 1.484e-30 91s Dose Response Model 91s 91s Model: emax 91s Fit-type: general 91s 91s Coefficients dose-response model 91s eMax ed50 91s 0.3771 0.3630 91s 91s Fitted to: 91s 1 2 3 4 91s 0.2846 0.2965 0.3502 0.3480 91s 91s Generalized residual sum of squares: 0.09815 91s Dose Response Model 91s 91s Model: emax 91s Fit-type: general 91s 91s Coefficients dose-response model 91s e0 eMax ed50 91s 0.2221 0.3771 0.3630 91s 91s Fitted to: 91s 0 1 2 3 4 91s 0.2220 0.5065 0.5185 0.5722 0.5700 91s 91s Generalized residual sum of squares: 0.09815 91s Dose Response Model 91s 91s Model: betaMod 91s Fit-type: general 91s 91s Coefficients dose-response model 91s eMax delta1 delta2 91s 0.3468 0.2216 0.0500 91s 91s Fitted to: 91s 1 2 3 4 91s 0.2846 0.2965 0.3502 0.3480 91s 91s Generalized residual sum of squares: 0.0783 91s Dose Response Model 91s 91s Model: betaMod 91s Fit-type: general 91s 91s Coefficients dose-response model 91s e0 eMax delta1 delta2 91s 0.2222 0.3468 0.2216 0.0500 91s 91s Fitted to: 91s 0 1 2 3 4 91s 0.2220 0.5065 0.5185 0.5722 0.5700 91s 91s Generalized residual sum of squares: 0.0783 91s $fit 91s [1] 0.0000000 0.2756421 0.3165257 0.3387105 0.3466573 91s 91s $se.fit 91s [1] 0.0000000 0.1235753 0.1106156 0.1135736 0.1263900 91s 91s $fit 91s [1] 0.2756421 0.3165257 0.3387105 0.3466573 91s 91s $se.fit 91s [1] 0.1235753 0.1106156 0.1135736 0.1263900 91s 91s e0 eMax delta1 delta2 91s e0 0.0118410628 -0.008186899 0.003722514 -0.0008419768 91s eMax -0.0081868987 0.014334651 -0.016984400 -0.0239850502 91s delta1 0.0037225143 -0.016984400 0.475384247 0.3641344062 91s delta2 -0.0008419768 -0.023985050 0.364134406 0.3356088151 91s eMax delta1 delta2 91s eMax 0.01433465 -0.0169844 -0.02398505 91s delta1 -0.01698440 0.4753842 0.36413441 91s delta2 -0.02398505 0.3641344 0.33560882 91s Message: Setting predType to "ls-means" for "type = general" 91s $fit 91s [1] 0.2219856 0.5065390 0.5185323 0.5721580 0.5699850 91s 91s $se.fit 91s [1] 0.1088272 0.1048057 0.1044027 0.1046862 0.1088405 91s 91s $fit 91s [1] 0.0000000 0.2845534 0.2965467 0.3501724 0.3479994 91s 91s $se.fit 91s [1] 0.0000000 0.1252903 0.1265494 0.1279290 0.1273279 91s 91s Message: Setting predType to "effect-curve" for placebo-adjusted data 91s $fit 91s [1] 0.2845534 0.2965467 0.3501724 0.3479994 91s 91s $se.fit 91s [1] 0.1252903 0.1265494 0.1279290 0.1273279 91s 91s d0 d1 d2 d3 d4 91s d0 0.011843358 0.003564965 0.003364270 0.003218371 0.003738601 91s d1 0.003564965 0.010984234 0.003307337 0.003163906 0.003675332 91s d2 0.003364270 0.003307337 0.010899929 0.002985790 0.003468425 91s d3 0.003218371 0.003163906 0.002985790 0.010959203 0.003318008 91s d4 0.003738601 0.003675332 0.003468425 0.003318008 0.011846244 91s d1 d2 d3 d4 91s d1 0.015697662 0.008221459 0.008223928 0.008215124 91s d2 0.008221459 0.016014746 0.008246506 0.008208911 91s d3 0.008223928 0.008246506 0.016365819 0.008204394 91s d4 0.008215124 0.008208911 0.008204394 0.016212400 91s d0 d1 d2 d3 d4 91s d0 0.011843358 0.003564965 0.003364270 0.003218371 0.003738601 91s d1 0.003564965 0.010984234 0.003307337 0.003163906 0.003675332 91s d2 0.003364270 0.003307337 0.010899929 0.002985790 0.003468425 91s d3 0.003218371 0.003163906 0.002985790 0.010959203 0.003318008 91s d4 0.003738601 0.003675332 0.003468425 0.003318008 0.011846244 91s gender2 -0.005149393 -0.005062250 -0.004777264 -0.004570087 -0.005308813 91s gender2 91s d0 -0.005149393 91s d1 -0.005062250 91s d2 -0.004777264 91s d3 -0.004570087 91s d4 -0.005308813 91s gender2 0.007312139 91s d0 d1 d2 d3 d4 91s d0 0.00819461 0.000000000 0.000000000 0.000000000 0.0000000 91s d1 0.00000000 0.007459197 0.000000000 0.000000000 0.0000000 91s d2 0.00000000 0.000000000 0.007757564 0.000000000 0.0000000 91s d3 0.00000000 0.000000000 0.000000000 0.008080796 0.0000000 91s d4 0.00000000 0.000000000 0.000000000 0.000000000 0.0079701 91s d1 d2 d3 d4 91s d1 0.015697662 0.008221459 0.008223928 0.008215124 91s d2 0.008221459 0.016014746 0.008246506 0.008208911 91s d3 0.008223928 0.008246506 0.016365819 0.008204394 91s d4 0.008215124 0.008208911 0.008204394 0.016212400 91s $fit 91s [1] 0.2845534 0.2965467 0.3501724 0.3479994 91s 91s $se.fit 91s [1] 0.1252903 0.1265494 0.1279290 0.1273279 91s 91s testgFit.R passed 91s testplanMod.R passed 92s Loading required package: DoseFinding 92s [1] 0.5099184 92s Calculated TD - optimal design: 92s 0 18.75 92s 0.50003 0.49997 92s Calculated TD - optimal design: 92s 0 104.52 92s 0.49993 0.50006 92s [1] 0.4286171 92s Calculated TD - optimal design: 92s 0 101.57 150 92s 0.43958 0.50000 0.06041 92s Calculated TD - optimal design: 92s 0 37.29 64.44 150 92s 0.40070 0.45303 0.09933 0.04694 92s [1] 0.1853293 92s Calculated TD - optimal design: 92s 0 50.22 92s 0.5 0.5 92s Calculated TD - optimal design: 92s 0 0.49 25.2 108.07 92s 0.44787 0.47652 0.05213 0.02348 92s [1] 0.130092 92s Calculated TD - optimal design: 92s 0 27 94.89 150 92s 0.44879 0.47519 0.05121 0.02481 92s [1] 0.5013672 92s Calculated TD - optimal design: 92s 0 0.35 150 92s 0.49865 0.50000 0.00135 92s [1] 0.05572985 92s [1] 4.478701e-01 4.765233e-01 5.212994e-02 2.347673e-02 6.509032e-09 92s [1] 4.478701e-01 4.765233e-01 5.212991e-02 2.347669e-02 5.680430e-09 93s [,1] [,2] [,3] [,4] [,5] [,6] [,7] [,8] [,9] 93s [1,] 0.246 0.142 0.122 0.000 0.000 0.241 0 0 0.249 93s [2,] 0.248 0.234 0.059 0.211 0.000 0.000 0 0 0.248 93s [3,] 0.247 0.000 0.000 0.224 0.081 0.203 0 0 0.246 93s [4,] 0.250 0.248 0.044 0.210 0.000 0.000 0 0 0.249 93s [5,] 0.250 0.248 0.191 0.064 0.000 0.000 0 0 0.247 93s [,1] [,2] [,3] [,4] [,5] [,6] [,7] [,8] [,9] 93s [1,] 0.49 0.01 0.00 0.00 0.00 0.00 0.36 0.14 0.00 93s [2,] 0.48 0.02 0.00 0.32 0.18 0.00 0.00 0.00 0.00 93s [3,] 0.21 0.29 0.00 0.00 0.00 0.46 0.04 0.00 0.00 93s [4,] 0.50 0.00 0.49 0.01 0.00 0.00 0.00 0.00 0.00 93s [5,] 0.49 0.02 0.48 0.00 0.00 0.00 0.00 0.00 0.01 93s [1] 0.8823949 93s Calculated D - optimal design: 93s 0 1 93s 0.5 0.5 94s Calculated TD - optimal design: 94s 0 0.25 0.5 1 94s 0.48951 0.35517 0.14483 0.01049 94s testsDesign.R passed 94s Loading required package: DoseFinding 94s [1] 3714.641 94s [1] 3714.641 94s Dose Response Model 94s 94s Model: betaMod 94s Fit-type: normal 94s 94s Residuals: 94s Min 1Q Median 3Q Max 94s -23.368 -3.727 0.129 3.894 16.152 94s 94s Coefficients with approx. stand. error: 94s Estimate Std. Error 94s e0 10.80 0.565 94s eMax 7.41 0.692 94s delta1 2.24 0.589 94s delta2 1.00 0.328 94s 94s Residual standard error: 5.64 94s Degrees of freedom: 585 94s 94s Formula: y ~ betaMod(x, e0, emax, delta1, delta2, 1.2 * max(datset$x)) 94s 94s Parameters: 94s Estimate Std. Error t value Pr(>|t|) 94s e0 10.7964 0.5653 19.098 < 2e-16 *** 94s emax 7.4106 0.6917 10.714 < 2e-16 *** 94s delta1 2.2357 0.5885 3.799 0.000161 *** 94s delta2 1.0047 0.3277 3.066 0.002271 ** 94s --- 94s Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 94s 94s Residual standard error: 5.637 on 585 degrees of freedom 94s 94s Number of iterations to convergence: 6 94s Achieved convergence tolerance: 4.028e-06 94s 94s e0 eMax delta1 delta2 94s e0 0.31958673 -0.28252697 0.20809234 0.09247897 94s eMax -0.28252697 0.47843297 -0.04177476 0.01244179 94s delta1 0.20809234 -0.04177476 0.34639417 0.18051781 94s delta2 0.09247897 0.01244179 0.18051781 0.10741016 94s e0 emax delta1 delta2 94s e0 0.31959066 -0.28253052 0.20808969 0.09247786 94s emax -0.28253052 0.47843381 -0.04177516 0.01244118 94s delta1 0.20808969 -0.04177516 0.34638195 0.18051234 94s delta2 0.09247786 0.01244118 0.18051234 0.10740756 94s $fit 94s [1] 6.0578751 6.8058158 7.2227652 6.0578751 3.1444084 6.8058158 7.2227652 94s [8] 3.1444084 6.0578751 0.0000000 6.0578751 6.0578751 7.2227652 3.1444084 94s [15] 0.8440180 0.0000000 6.0578751 3.1444084 3.1444084 0.0000000 7.2227652 94s [22] 0.0000000 7.2227652 6.8058158 6.8058158 3.1444084 6.8058158 6.8058158 94s [29] 3.1444084 6.0578751 7.2227652 6.8058158 3.1444084 3.1444084 3.1444084 94s [36] 0.0000000 0.0000000 3.1444084 6.8058158 3.1444084 3.1444084 0.8440180 94s [43] 3.1444084 6.0578751 3.1444084 6.0578751 0.8440180 7.2227652 0.8440180 94s [50] 0.8440180 0.0000000 7.2227652 6.8058158 6.8058158 7.2227652 3.1444084 94s [57] 7.2227652 6.8058158 0.8440180 0.8440180 3.1444084 0.0000000 7.2227652 94s [64] 6.8058158 6.8058158 6.8058158 0.0000000 7.2227652 3.1444084 6.0578751 94s [71] 0.0000000 0.8440180 0.8440180 6.8058158 3.1444084 3.1444084 6.0578751 94s [78] 0.0000000 6.0578751 6.8058158 6.8058158 3.1444084 3.1444084 3.1444084 94s [85] 3.1444084 7.2227652 6.8058158 0.8440180 0.0000000 0.8440180 7.2227652 94s [92] 6.8058158 3.1444084 7.2227652 6.0578751 6.8058158 6.0578751 6.8058158 94s [99] 6.8058158 6.8058158 3.1444084 6.0578751 6.8058158 0.0000000 6.0578751 94s [106] 6.8058158 0.0000000 6.8058158 3.1444084 3.1444084 0.8440180 6.8058158 94s [113] 6.0578751 3.1444084 0.1731496 6.0578751 6.0578751 0.0000000 6.8058158 94s [120] 0.0000000 0.0000000 6.8058158 0.1731496 0.8440180 0.0000000 6.0578751 94s [127] 6.8058158 3.1444084 6.0578751 0.8440180 6.8058158 0.8440180 7.2227652 94s [134] 6.8058158 3.1444084 6.0578751 6.8058158 7.2227652 6.8058158 0.1731496 94s [141] 6.8058158 6.8058158 0.8440180 6.8058158 6.0578751 7.2227652 6.8058158 94s [148] 3.1444084 3.1444084 0.0000000 6.0578751 3.1444084 0.0000000 3.1444084 94s [155] 6.8058158 7.2227652 6.8058158 0.0000000 0.0000000 0.8440180 3.1444084 94s [162] 0.0000000 0.1731496 3.1444084 3.1444084 6.0578751 0.0000000 0.8440180 94s [169] 0.0000000 3.1444084 3.1444084 6.0578751 6.0578751 0.0000000 7.2227652 94s [176] 0.8440180 0.0000000 6.0578751 0.0000000 7.2227652 0.0000000 3.1444084 94s [183] 6.0578751 6.0578751 3.1444084 3.1444084 0.1731496 7.2227652 3.1444084 94s [190] 0.8440180 7.2227652 7.2227652 0.8440180 0.0000000 7.2227652 3.1444084 94s [197] 7.2227652 7.2227652 0.1731496 3.1444084 0.0000000 7.2227652 3.1444084 94s [204] 6.8058158 6.8058158 7.2227652 6.8058158 7.2227652 0.8440180 6.0578751 94s [211] 3.1444084 3.1444084 3.1444084 0.0000000 0.0000000 6.0578751 6.0578751 94s [218] 3.1444084 3.1444084 0.1731496 7.2227652 7.2227652 0.0000000 0.8440180 94s [225] 7.2227652 0.8440180 3.1444084 0.8440180 0.0000000 7.2227652 3.1444084 94s [232] 6.8058158 6.8058158 3.1444084 0.8440180 6.0578751 0.8440180 0.0000000 94s [239] 0.0000000 6.8058158 7.2227652 6.8058158 6.0578751 3.1444084 7.2227652 94s [246] 6.8058158 3.1444084 7.2227652 0.8440180 0.8440180 7.2227652 6.0578751 94s [253] 0.1731496 7.2227652 6.8058158 6.8058158 7.2227652 6.8058158 6.0578751 94s [260] 6.8058158 0.8440180 6.8058158 6.8058158 7.2227652 6.0578751 0.8440180 94s [267] 6.8058158 3.1444084 3.1444084 0.8440180 3.1444084 0.8440180 0.0000000 94s [274] 3.1444084 0.8440180 0.8440180 0.1731496 6.0578751 6.0578751 0.8440180 94s [281] 0.0000000 0.0000000 0.0000000 6.0578751 0.0000000 3.1444084 3.1444084 94s [288] 0.0000000 0.8440180 6.0578751 0.0000000 6.0578751 7.2227652 0.8440180 94s [295] 7.2227652 6.8058158 0.8440180 0.1731496 7.2227652 7.2227652 0.0000000 94s [302] 6.0578751 6.8058158 7.2227652 0.0000000 6.0578751 6.0578751 6.8058158 94s [309] 0.0000000 0.8440180 6.0578751 6.8058158 6.8058158 3.1444084 0.8440180 94s [316] 6.8058158 3.1444084 7.2227652 6.0578751 0.8440180 3.1444084 0.8440180 94s [323] 7.2227652 6.0578751 6.0578751 7.2227652 3.1444084 6.0578751 6.8058158 94s [330] 0.8440180 0.8440180 6.8058158 6.8058158 7.2227652 0.8440180 3.1444084 94s [337] 3.1444084 6.0578751 6.0578751 0.0000000 3.1444084 6.8058158 0.8440180 94s [344] 3.1444084 6.0578751 7.2227652 3.1444084 3.1444084 0.1731496 6.0578751 94s [351] 7.2227652 7.2227652 3.1444084 6.0578751 3.1444084 6.0578751 3.1444084 94s [358] 6.0578751 3.1444084 7.2227652 0.8440180 3.1444084 6.8058158 0.8440180 94s [365] 3.1444084 0.1731496 6.8058158 3.1444084 6.8058158 7.2227652 3.1444084 94s [372] 6.8058158 6.8058158 3.1444084 0.0000000 0.8440180 0.8440180 6.8058158 94s [379] 0.0000000 7.2227652 0.8440180 0.8440180 6.0578751 3.1444084 0.8440180 94s [386] 7.2227652 3.1444084 7.2227652 6.8058158 3.1444084 3.1444084 6.8058158 94s [393] 6.0578751 3.1444084 6.8058158 0.0000000 6.8058158 0.8440180 0.0000000 94s [400] 3.1444084 6.8058158 0.8440180 6.0578751 6.0578751 0.1731496 6.0578751 94s [407] 0.8440180 3.1444084 0.8440180 3.1444084 3.1444084 6.8058158 0.8440180 94s [414] 6.8058158 7.2227652 0.0000000 6.8058158 0.8440180 0.0000000 7.2227652 94s [421] 6.8058158 3.1444084 3.1444084 6.8058158 6.8058158 6.0578751 6.0578751 94s [428] 6.0578751 7.2227652 0.1731496 7.2227652 6.8058158 0.0000000 3.1444084 94s [435] 7.2227652 6.8058158 6.8058158 0.8440180 0.0000000 3.1444084 7.2227652 94s [442] 6.8058158 6.0578751 3.1444084 6.0578751 7.2227652 6.0578751 7.2227652 94s [449] 0.0000000 7.2227652 7.2227652 0.8440180 6.0578751 6.8058158 0.0000000 94s [456] 0.8440180 6.0578751 0.1731496 3.1444084 7.2227652 7.2227652 6.0578751 94s [463] 6.0578751 3.1444084 0.1731496 7.2227652 6.8058158 0.8440180 0.0000000 94s [470] 0.8440180 6.8058158 6.8058158 7.2227652 6.0578751 7.2227652 0.8440180 94s [477] 3.1444084 7.2227652 7.2227652 0.1731496 3.1444084 7.2227652 7.2227652 94s [484] 3.1444084 6.8058158 0.0000000 7.2227652 6.0578751 0.8440180 3.1444084 94s [491] 7.2227652 7.2227652 6.0578751 3.1444084 7.2227652 6.0578751 0.0000000 94s [498] 0.8440180 6.0578751 6.8058158 3.1444084 6.0578751 0.0000000 7.2227652 94s [505] 3.1444084 0.0000000 0.8440180 7.2227652 6.8058158 6.8058158 3.1444084 94s [512] 6.8058158 0.1731496 0.0000000 3.1444084 3.1444084 3.1444084 6.8058158 94s [519] 6.8058158 0.0000000 6.8058158 6.8058158 3.1444084 7.2227652 3.1444084 94s [526] 0.8440180 0.8440180 7.2227652 6.0578751 6.0578751 3.1444084 6.8058158 94s [533] 7.2227652 6.0578751 6.8058158 3.1444084 3.1444084 3.1444084 7.2227652 94s [540] 0.0000000 0.0000000 6.8058158 3.1444084 0.1731496 0.0000000 6.0578751 94s [547] 7.2227652 6.0578751 6.0578751 7.2227652 6.0578751 6.0578751 6.8058158 94s [554] 0.0000000 0.0000000 3.1444084 6.0578751 7.2227652 7.2227652 3.1444084 94s [561] 3.1444084 6.8058158 7.2227652 6.8058158 6.8058158 0.0000000 6.8058158 94s [568] 3.1444084 7.2227652 0.8440180 0.0000000 3.1444084 0.8440180 6.8058158 94s [575] 7.2227652 3.1444084 6.0578751 0.8440180 6.8058158 3.1444084 0.0000000 94s [582] 7.2227652 6.8058158 0.8440180 6.0578751 3.1444084 6.8058158 0.8440180 94s [589] 6.0578751 94s 94s $se.fit 94s [1] 0.7643614 0.6580335 0.7488551 0.7643614 0.7997224 0.6580335 0.7488551 94s [8] 0.7997224 0.7643614 0.0000000 0.7643614 0.7643614 0.7488551 0.7997224 94s [15] 0.4790120 0.0000000 0.7643614 0.7997224 0.7997224 0.0000000 0.7488551 94s [22] 0.0000000 0.7488551 0.6580335 0.6580335 0.7997224 0.6580335 0.6580335 94s [29] 0.7997224 0.7643614 0.7488551 0.6580335 0.7997224 0.7997224 0.7997224 94s [36] 0.0000000 0.0000000 0.7997224 0.6580335 0.7997224 0.7997224 0.4790120 94s [43] 0.7997224 0.7643614 0.7997224 0.7643614 0.4790120 0.7488551 0.4790120 94s [50] 0.4790120 0.0000000 0.7488551 0.6580335 0.6580335 0.7488551 0.7997224 94s [57] 0.7488551 0.6580335 0.4790120 0.4790120 0.7997224 0.0000000 0.7488551 94s [64] 0.6580335 0.6580335 0.6580335 0.0000000 0.7488551 0.7997224 0.7643614 94s [71] 0.0000000 0.4790120 0.4790120 0.6580335 0.7997224 0.7997224 0.7643614 94s [78] 0.0000000 0.7643614 0.6580335 0.6580335 0.7997224 0.7997224 0.7997224 94s [85] 0.7997224 0.7488551 0.6580335 0.4790120 0.0000000 0.4790120 0.7488551 94s [92] 0.6580335 0.7997224 0.7488551 0.7643614 0.6580335 0.7643614 0.6580335 94s [99] 0.6580335 0.6580335 0.7997224 0.7643614 0.6580335 0.0000000 0.7643614 94s [106] 0.6580335 0.0000000 0.6580335 0.7997224 0.7997224 0.4790120 0.6580335 94s [113] 0.7643614 0.7997224 0.1680259 0.7643614 0.7643614 0.0000000 0.6580335 94s [120] 0.0000000 0.0000000 0.6580335 0.1680259 0.4790120 0.0000000 0.7643614 94s [127] 0.6580335 0.7997224 0.7643614 0.4790120 0.6580335 0.4790120 0.7488551 94s [134] 0.6580335 0.7997224 0.7643614 0.6580335 0.7488551 0.6580335 0.1680259 94s [141] 0.6580335 0.6580335 0.4790120 0.6580335 0.7643614 0.7488551 0.6580335 94s [148] 0.7997224 0.7997224 0.0000000 0.7643614 0.7997224 0.0000000 0.7997224 94s [155] 0.6580335 0.7488551 0.6580335 0.0000000 0.0000000 0.4790120 0.7997224 94s [162] 0.0000000 0.1680259 0.7997224 0.7997224 0.7643614 0.0000000 0.4790120 94s [169] 0.0000000 0.7997224 0.7997224 0.7643614 0.7643614 0.0000000 0.7488551 94s [176] 0.4790120 0.0000000 0.7643614 0.0000000 0.7488551 0.0000000 0.7997224 94s [183] 0.7643614 0.7643614 0.7997224 0.7997224 0.1680259 0.7488551 0.7997224 94s [190] 0.4790120 0.7488551 0.7488551 0.4790120 0.0000000 0.7488551 0.7997224 94s [197] 0.7488551 0.7488551 0.1680259 0.7997224 0.0000000 0.7488551 0.7997224 94s [204] 0.6580335 0.6580335 0.7488551 0.6580335 0.7488551 0.4790120 0.7643614 94s [211] 0.7997224 0.7997224 0.7997224 0.0000000 0.0000000 0.7643614 0.7643614 94s [218] 0.7997224 0.7997224 0.1680259 0.7488551 0.7488551 0.0000000 0.4790120 94s [225] 0.7488551 0.4790120 0.7997224 0.4790120 0.0000000 0.7488551 0.7997224 94s [232] 0.6580335 0.6580335 0.7997224 0.4790120 0.7643614 0.4790120 0.0000000 94s [239] 0.0000000 0.6580335 0.7488551 0.6580335 0.7643614 0.7997224 0.7488551 94s [246] 0.6580335 0.7997224 0.7488551 0.4790120 0.4790120 0.7488551 0.7643614 94s [253] 0.1680259 0.7488551 0.6580335 0.6580335 0.7488551 0.6580335 0.7643614 94s [260] 0.6580335 0.4790120 0.6580335 0.6580335 0.7488551 0.7643614 0.4790120 94s [267] 0.6580335 0.7997224 0.7997224 0.4790120 0.7997224 0.4790120 0.0000000 94s [274] 0.7997224 0.4790120 0.4790120 0.1680259 0.7643614 0.7643614 0.4790120 94s [281] 0.0000000 0.0000000 0.0000000 0.7643614 0.0000000 0.7997224 0.7997224 94s [288] 0.0000000 0.4790120 0.7643614 0.0000000 0.7643614 0.7488551 0.4790120 94s [295] 0.7488551 0.6580335 0.4790120 0.1680259 0.7488551 0.7488551 0.0000000 94s [302] 0.7643614 0.6580335 0.7488551 0.0000000 0.7643614 0.7643614 0.6580335 94s [309] 0.0000000 0.4790120 0.7643614 0.6580335 0.6580335 0.7997224 0.4790120 94s [316] 0.6580335 0.7997224 0.7488551 0.7643614 0.4790120 0.7997224 0.4790120 94s [323] 0.7488551 0.7643614 0.7643614 0.7488551 0.7997224 0.7643614 0.6580335 94s [330] 0.4790120 0.4790120 0.6580335 0.6580335 0.7488551 0.4790120 0.7997224 94s [337] 0.7997224 0.7643614 0.7643614 0.0000000 0.7997224 0.6580335 0.4790120 94s [344] 0.7997224 0.7643614 0.7488551 0.7997224 0.7997224 0.1680259 0.7643614 94s [351] 0.7488551 0.7488551 0.7997224 0.7643614 0.7997224 0.7643614 0.7997224 94s [358] 0.7643614 0.7997224 0.7488551 0.4790120 0.7997224 0.6580335 0.4790120 94s [365] 0.7997224 0.1680259 0.6580335 0.7997224 0.6580335 0.7488551 0.7997224 94s [372] 0.6580335 0.6580335 0.7997224 0.0000000 0.4790120 0.4790120 0.6580335 94s [379] 0.0000000 0.7488551 0.4790120 0.4790120 0.7643614 0.7997224 0.4790120 94s [386] 0.7488551 0.7997224 0.7488551 0.6580335 0.7997224 0.7997224 0.6580335 94s [393] 0.7643614 0.7997224 0.6580335 0.0000000 0.6580335 0.4790120 0.0000000 94s [400] 0.7997224 0.6580335 0.4790120 0.7643614 0.7643614 0.1680259 0.7643614 94s [407] 0.4790120 0.7997224 0.4790120 0.7997224 0.7997224 0.6580335 0.4790120 94s [414] 0.6580335 0.7488551 0.0000000 0.6580335 0.4790120 0.0000000 0.7488551 94s [421] 0.6580335 0.7997224 0.7997224 0.6580335 0.6580335 0.7643614 0.7643614 94s [428] 0.7643614 0.7488551 0.1680259 0.7488551 0.6580335 0.0000000 0.7997224 94s [435] 0.7488551 0.6580335 0.6580335 0.4790120 0.0000000 0.7997224 0.7488551 94s [442] 0.6580335 0.7643614 0.7997224 0.7643614 0.7488551 0.7643614 0.7488551 94s [449] 0.0000000 0.7488551 0.7488551 0.4790120 0.7643614 0.6580335 0.0000000 94s [456] 0.4790120 0.7643614 0.1680259 0.7997224 0.7488551 0.7488551 0.7643614 94s [463] 0.7643614 0.7997224 0.1680259 0.7488551 0.6580335 0.4790120 0.0000000 94s [470] 0.4790120 0.6580335 0.6580335 0.7488551 0.7643614 0.7488551 0.4790120 94s [477] 0.7997224 0.7488551 0.7488551 0.1680259 0.7997224 0.7488551 0.7488551 94s [484] 0.7997224 0.6580335 0.0000000 0.7488551 0.7643614 0.4790120 0.7997224 94s [491] 0.7488551 0.7488551 0.7643614 0.7997224 0.7488551 0.7643614 0.0000000 94s [498] 0.4790120 0.7643614 0.6580335 0.7997224 0.7643614 0.0000000 0.7488551 94s [505] 0.7997224 0.0000000 0.4790120 0.7488551 0.6580335 0.6580335 0.7997224 94s [512] 0.6580335 0.1680259 0.0000000 0.7997224 0.7997224 0.7997224 0.6580335 94s [519] 0.6580335 0.0000000 0.6580335 0.6580335 0.7997224 0.7488551 0.7997224 94s [526] 0.4790120 0.4790120 0.7488551 0.7643614 0.7643614 0.7997224 0.6580335 94s [533] 0.7488551 0.7643614 0.6580335 0.7997224 0.7997224 0.7997224 0.7488551 94s [540] 0.0000000 0.0000000 0.6580335 0.7997224 0.1680259 0.0000000 0.7643614 94s [547] 0.7488551 0.7643614 0.7643614 0.7488551 0.7643614 0.7643614 0.6580335 94s [554] 0.0000000 0.0000000 0.7997224 0.7643614 0.7488551 0.7488551 0.7997224 94s [561] 0.7997224 0.6580335 0.7488551 0.6580335 0.6580335 0.0000000 0.6580335 94s [568] 0.7997224 0.7488551 0.4790120 0.0000000 0.7997224 0.4790120 0.6580335 94s [575] 0.7488551 0.7997224 0.7643614 0.4790120 0.6580335 0.7997224 0.0000000 94s [582] 0.7488551 0.6580335 0.4790120 0.7643614 0.7997224 0.6580335 0.4790120 94s [589] 0.7643614 94s 94s $fit 94s [1] 16.85434 17.60229 18.01923 16.85434 13.94088 17.60229 18.01923 13.94088 94s [9] 16.85434 10.79647 16.85434 16.85434 18.01923 13.94088 11.64049 10.79647 94s [17] 16.85434 13.94088 13.94088 10.79647 18.01923 10.79647 18.01923 17.60229 94s [25] 17.60229 13.94088 17.60229 17.60229 13.94088 16.85434 18.01923 17.60229 94s [33] 13.94088 13.94088 13.94088 10.79647 10.79647 13.94088 17.60229 13.94088 94s [41] 13.94088 11.64049 13.94088 16.85434 13.94088 16.85434 11.64049 18.01923 94s [49] 11.64049 11.64049 10.79647 18.01923 17.60229 17.60229 18.01923 13.94088 94s [57] 18.01923 17.60229 11.64049 11.64049 13.94088 10.79647 18.01923 17.60229 94s [65] 17.60229 17.60229 10.79647 18.01923 13.94088 16.85434 10.79647 11.64049 94s [73] 11.64049 17.60229 13.94088 13.94088 16.85434 10.79647 16.85434 17.60229 94s [81] 17.60229 13.94088 13.94088 13.94088 13.94088 18.01923 17.60229 11.64049 94s [89] 10.79647 11.64049 18.01923 17.60229 13.94088 18.01923 16.85434 17.60229 94s [97] 16.85434 17.60229 17.60229 17.60229 13.94088 16.85434 17.60229 10.79647 94s [105] 16.85434 17.60229 10.79647 17.60229 13.94088 13.94088 11.64049 17.60229 94s [113] 16.85434 13.94088 10.96962 16.85434 16.85434 10.79647 17.60229 10.79647 94s [121] 10.79647 17.60229 10.96962 11.64049 10.79647 16.85434 17.60229 13.94088 94s [129] 16.85434 11.64049 17.60229 11.64049 18.01923 17.60229 13.94088 16.85434 94s [137] 17.60229 18.01923 17.60229 10.96962 17.60229 17.60229 11.64049 17.60229 94s [145] 16.85434 18.01923 17.60229 13.94088 13.94088 10.79647 16.85434 13.94088 94s [153] 10.79647 13.94088 17.60229 18.01923 17.60229 10.79647 10.79647 11.64049 94s [161] 13.94088 10.79647 10.96962 13.94088 13.94088 16.85434 10.79647 11.64049 94s [169] 10.79647 13.94088 13.94088 16.85434 16.85434 10.79647 18.01923 11.64049 94s [177] 10.79647 16.85434 10.79647 18.01923 10.79647 13.94088 16.85434 16.85434 94s [185] 13.94088 13.94088 10.96962 18.01923 13.94088 11.64049 18.01923 18.01923 94s [193] 11.64049 10.79647 18.01923 13.94088 18.01923 18.01923 10.96962 13.94088 94s [201] 10.79647 18.01923 13.94088 17.60229 17.60229 18.01923 17.60229 18.01923 94s [209] 11.64049 16.85434 13.94088 13.94088 13.94088 10.79647 10.79647 16.85434 94s [217] 16.85434 13.94088 13.94088 10.96962 18.01923 18.01923 10.79647 11.64049 94s [225] 18.01923 11.64049 13.94088 11.64049 10.79647 18.01923 13.94088 17.60229 94s [233] 17.60229 13.94088 11.64049 16.85434 11.64049 10.79647 10.79647 17.60229 94s [241] 18.01923 17.60229 16.85434 13.94088 18.01923 17.60229 13.94088 18.01923 94s [249] 11.64049 11.64049 18.01923 16.85434 10.96962 18.01923 17.60229 17.60229 94s [257] 18.01923 17.60229 16.85434 17.60229 11.64049 17.60229 17.60229 18.01923 94s [265] 16.85434 11.64049 17.60229 13.94088 13.94088 11.64049 13.94088 11.64049 94s [273] 10.79647 13.94088 11.64049 11.64049 10.96962 16.85434 16.85434 11.64049 94s [281] 10.79647 10.79647 10.79647 16.85434 10.79647 13.94088 13.94088 10.79647 94s [289] 11.64049 16.85434 10.79647 16.85434 18.01923 11.64049 18.01923 17.60229 94s [297] 11.64049 10.96962 18.01923 18.01923 10.79647 16.85434 17.60229 18.01923 94s [305] 10.79647 16.85434 16.85434 17.60229 10.79647 11.64049 16.85434 17.60229 94s [313] 17.60229 13.94088 11.64049 17.60229 13.94088 18.01923 16.85434 11.64049 94s [321] 13.94088 11.64049 18.01923 16.85434 16.85434 18.01923 13.94088 16.85434 94s [329] 17.60229 11.64049 11.64049 17.60229 17.60229 18.01923 11.64049 13.94088 94s [337] 13.94088 16.85434 16.85434 10.79647 13.94088 17.60229 11.64049 13.94088 94s [345] 16.85434 18.01923 13.94088 13.94088 10.96962 16.85434 18.01923 18.01923 94s [353] 13.94088 16.85434 13.94088 16.85434 13.94088 16.85434 13.94088 18.01923 94s [361] 11.64049 13.94088 17.60229 11.64049 13.94088 10.96962 17.60229 13.94088 94s [369] 17.60229 18.01923 13.94088 17.60229 17.60229 13.94088 10.79647 11.64049 94s [377] 11.64049 17.60229 10.79647 18.01923 11.64049 11.64049 16.85434 13.94088 94s [385] 11.64049 18.01923 13.94088 18.01923 17.60229 13.94088 13.94088 17.60229 94s [393] 16.85434 13.94088 17.60229 10.79647 17.60229 11.64049 10.79647 13.94088 94s [401] 17.60229 11.64049 16.85434 16.85434 10.96962 16.85434 11.64049 13.94088 94s [409] 11.64049 13.94088 13.94088 17.60229 11.64049 17.60229 18.01923 10.79647 94s [417] 17.60229 11.64049 10.79647 18.01923 17.60229 13.94088 13.94088 17.60229 94s [425] 17.60229 16.85434 16.85434 16.85434 18.01923 10.96962 18.01923 17.60229 94s [433] 10.79647 13.94088 18.01923 17.60229 17.60229 11.64049 10.79647 13.94088 94s [441] 18.01923 17.60229 16.85434 13.94088 16.85434 18.01923 16.85434 18.01923 94s [449] 10.79647 18.01923 18.01923 11.64049 16.85434 17.60229 10.79647 11.64049 94s [457] 16.85434 10.96962 13.94088 18.01923 18.01923 16.85434 16.85434 13.94088 94s [465] 10.96962 18.01923 17.60229 11.64049 10.79647 11.64049 17.60229 17.60229 94s [473] 18.01923 16.85434 18.01923 11.64049 13.94088 18.01923 18.01923 10.96962 94s [481] 13.94088 18.01923 18.01923 13.94088 17.60229 10.79647 18.01923 16.85434 94s [489] 11.64049 13.94088 18.01923 18.01923 16.85434 13.94088 18.01923 16.85434 94s [497] 10.79647 11.64049 16.85434 17.60229 13.94088 16.85434 10.79647 18.01923 94s [505] 13.94088 10.79647 11.64049 18.01923 17.60229 17.60229 13.94088 17.60229 94s [513] 10.96962 10.79647 13.94088 13.94088 13.94088 17.60229 17.60229 10.79647 94s [521] 17.60229 17.60229 13.94088 18.01923 13.94088 11.64049 11.64049 18.01923 94s [529] 16.85434 16.85434 13.94088 17.60229 18.01923 16.85434 17.60229 13.94088 94s [537] 13.94088 13.94088 18.01923 10.79647 10.79647 17.60229 13.94088 10.96962 94s [545] 10.79647 16.85434 18.01923 16.85434 16.85434 18.01923 16.85434 16.85434 94s [553] 17.60229 10.79647 10.79647 13.94088 16.85434 18.01923 18.01923 13.94088 94s [561] 13.94088 17.60229 18.01923 17.60229 17.60229 10.79647 17.60229 13.94088 94s [569] 18.01923 11.64049 10.79647 13.94088 11.64049 17.60229 18.01923 13.94088 94s [577] 16.85434 11.64049 17.60229 13.94088 10.79647 18.01923 17.60229 11.64049 94s [585] 16.85434 13.94088 17.60229 11.64049 16.85434 94s 94s $se.fit 94s [1] 0.4716508 0.3621952 0.5408090 0.4716508 0.4610877 0.3621952 0.5408090 94s [8] 0.4610877 0.4716508 0.5653200 0.4716508 0.4716508 0.5408090 0.4610877 94s [15] 0.3763389 0.5653200 0.4716508 0.4610877 0.4610877 0.5653200 0.5408090 94s [22] 0.5653200 0.5408090 0.3621952 0.3621952 0.4610877 0.3621952 0.3621952 94s [29] 0.4610877 0.4716508 0.5408090 0.3621952 0.4610877 0.4610877 0.4610877 94s [36] 0.5653200 0.5653200 0.4610877 0.3621952 0.4610877 0.4610877 0.3763389 94s [43] 0.4610877 0.4716508 0.4610877 0.4716508 0.3763389 0.5408090 0.3763389 94s [50] 0.3763389 0.5653200 0.5408090 0.3621952 0.3621952 0.5408090 0.4610877 94s [57] 0.5408090 0.3621952 0.3763389 0.3763389 0.4610877 0.5653200 0.5408090 94s [64] 0.3621952 0.3621952 0.3621952 0.5653200 0.5408090 0.4610877 0.4716508 94s [71] 0.5653200 0.3763389 0.3763389 0.3621952 0.4610877 0.4610877 0.4716508 94s [78] 0.5653200 0.4716508 0.3621952 0.3621952 0.4610877 0.4610877 0.4610877 94s [85] 0.4610877 0.5408090 0.3621952 0.3763389 0.5653200 0.3763389 0.5408090 94s [92] 0.3621952 0.4610877 0.5408090 0.4716508 0.3621952 0.4716508 0.3621952 94s [99] 0.3621952 0.3621952 0.4610877 0.4716508 0.3621952 0.5653200 0.4716508 94s [106] 0.3621952 0.5653200 0.3621952 0.4610877 0.4610877 0.3763389 0.3621952 94s [113] 0.4716508 0.4610877 0.4616804 0.4716508 0.4716508 0.5653200 0.3621952 94s [120] 0.5653200 0.5653200 0.3621952 0.4616804 0.3763389 0.5653200 0.4716508 94s [127] 0.3621952 0.4610877 0.4716508 0.3763389 0.3621952 0.3763389 0.5408090 94s [134] 0.3621952 0.4610877 0.4716508 0.3621952 0.5408090 0.3621952 0.4616804 94s [141] 0.3621952 0.3621952 0.3763389 0.3621952 0.4716508 0.5408090 0.3621952 94s [148] 0.4610877 0.4610877 0.5653200 0.4716508 0.4610877 0.5653200 0.4610877 94s [155] 0.3621952 0.5408090 0.3621952 0.5653200 0.5653200 0.3763389 0.4610877 94s [162] 0.5653200 0.4616804 0.4610877 0.4610877 0.4716508 0.5653200 0.3763389 94s [169] 0.5653200 0.4610877 0.4610877 0.4716508 0.4716508 0.5653200 0.5408090 94s [176] 0.3763389 0.5653200 0.4716508 0.5653200 0.5408090 0.5653200 0.4610877 94s [183] 0.4716508 0.4716508 0.4610877 0.4610877 0.4616804 0.5408090 0.4610877 94s [190] 0.3763389 0.5408090 0.5408090 0.3763389 0.5653200 0.5408090 0.4610877 94s [197] 0.5408090 0.5408090 0.4616804 0.4610877 0.5653200 0.5408090 0.4610877 94s [204] 0.3621952 0.3621952 0.5408090 0.3621952 0.5408090 0.3763389 0.4716508 94s [211] 0.4610877 0.4610877 0.4610877 0.5653200 0.5653200 0.4716508 0.4716508 94s [218] 0.4610877 0.4610877 0.4616804 0.5408090 0.5408090 0.5653200 0.3763389 94s [225] 0.5408090 0.3763389 0.4610877 0.3763389 0.5653200 0.5408090 0.4610877 94s [232] 0.3621952 0.3621952 0.4610877 0.3763389 0.4716508 0.3763389 0.5653200 94s [239] 0.5653200 0.3621952 0.5408090 0.3621952 0.4716508 0.4610877 0.5408090 94s [246] 0.3621952 0.4610877 0.5408090 0.3763389 0.3763389 0.5408090 0.4716508 94s [253] 0.4616804 0.5408090 0.3621952 0.3621952 0.5408090 0.3621952 0.4716508 94s [260] 0.3621952 0.3763389 0.3621952 0.3621952 0.5408090 0.4716508 0.3763389 94s [267] 0.3621952 0.4610877 0.4610877 0.3763389 0.4610877 0.3763389 0.5653200 94s [274] 0.4610877 0.3763389 0.3763389 0.4616804 0.4716508 0.4716508 0.3763389 94s [281] 0.5653200 0.5653200 0.5653200 0.4716508 0.5653200 0.4610877 0.4610877 94s [288] 0.5653200 0.3763389 0.4716508 0.5653200 0.4716508 0.5408090 0.3763389 94s [295] 0.5408090 0.3621952 0.3763389 0.4616804 0.5408090 0.5408090 0.5653200 94s [302] 0.4716508 0.3621952 0.5408090 0.5653200 0.4716508 0.4716508 0.3621952 94s [309] 0.5653200 0.3763389 0.4716508 0.3621952 0.3621952 0.4610877 0.3763389 94s [316] 0.3621952 0.4610877 0.5408090 0.4716508 0.3763389 0.4610877 0.3763389 94s [323] 0.5408090 0.4716508 0.4716508 0.5408090 0.4610877 0.4716508 0.3621952 94s [330] 0.3763389 0.3763389 0.3621952 0.3621952 0.5408090 0.3763389 0.4610877 94s [337] 0.4610877 0.4716508 0.4716508 0.5653200 0.4610877 0.3621952 0.3763389 94s [344] 0.4610877 0.4716508 0.5408090 0.4610877 0.4610877 0.4616804 0.4716508 94s [351] 0.5408090 0.5408090 0.4610877 0.4716508 0.4610877 0.4716508 0.4610877 94s [358] 0.4716508 0.4610877 0.5408090 0.3763389 0.4610877 0.3621952 0.3763389 94s [365] 0.4610877 0.4616804 0.3621952 0.4610877 0.3621952 0.5408090 0.4610877 94s [372] 0.3621952 0.3621952 0.4610877 0.5653200 0.3763389 0.3763389 0.3621952 94s [379] 0.5653200 0.5408090 0.3763389 0.3763389 0.4716508 0.4610877 0.3763389 94s [386] 0.5408090 0.4610877 0.5408090 0.3621952 0.4610877 0.4610877 0.3621952 94s [393] 0.4716508 0.4610877 0.3621952 0.5653200 0.3621952 0.3763389 0.5653200 94s [400] 0.4610877 0.3621952 0.3763389 0.4716508 0.4716508 0.4616804 0.4716508 94s [407] 0.3763389 0.4610877 0.3763389 0.4610877 0.4610877 0.3621952 0.3763389 94s [414] 0.3621952 0.5408090 0.5653200 0.3621952 0.3763389 0.5653200 0.5408090 94s [421] 0.3621952 0.4610877 0.4610877 0.3621952 0.3621952 0.4716508 0.4716508 94s [428] 0.4716508 0.5408090 0.4616804 0.5408090 0.3621952 0.5653200 0.4610877 94s [435] 0.5408090 0.3621952 0.3621952 0.3763389 0.5653200 0.4610877 0.5408090 94s [442] 0.3621952 0.4716508 0.4610877 0.4716508 0.5408090 0.4716508 0.5408090 94s [449] 0.5653200 0.5408090 0.5408090 0.3763389 0.4716508 0.3621952 0.5653200 94s [456] 0.3763389 0.4716508 0.4616804 0.4610877 0.5408090 0.5408090 0.4716508 94s [463] 0.4716508 0.4610877 0.4616804 0.5408090 0.3621952 0.3763389 0.5653200 94s [470] 0.3763389 0.3621952 0.3621952 0.5408090 0.4716508 0.5408090 0.3763389 94s [477] 0.4610877 0.5408090 0.5408090 0.4616804 0.4610877 0.5408090 0.5408090 94s [484] 0.4610877 0.3621952 0.5653200 0.5408090 0.4716508 0.3763389 0.4610877 94s [491] 0.5408090 0.5408090 0.4716508 0.4610877 0.5408090 0.4716508 0.5653200 94s [498] 0.3763389 0.4716508 0.3621952 0.4610877 0.4716508 0.5653200 0.5408090 94s [505] 0.4610877 0.5653200 0.3763389 0.5408090 0.3621952 0.3621952 0.4610877 94s [512] 0.3621952 0.4616804 0.5653200 0.4610877 0.4610877 0.4610877 0.3621952 94s [519] 0.3621952 0.5653200 0.3621952 0.3621952 0.4610877 0.5408090 0.4610877 94s [526] 0.3763389 0.3763389 0.5408090 0.4716508 0.4716508 0.4610877 0.3621952 94s [533] 0.5408090 0.4716508 0.3621952 0.4610877 0.4610877 0.4610877 0.5408090 94s [540] 0.5653200 0.5653200 0.3621952 0.4610877 0.4616804 0.5653200 0.4716508 94s [547] 0.5408090 0.4716508 0.4716508 0.5408090 0.4716508 0.4716508 0.3621952 94s [554] 0.5653200 0.5653200 0.4610877 0.4716508 0.5408090 0.5408090 0.4610877 94s [561] 0.4610877 0.3621952 0.5408090 0.3621952 0.3621952 0.5653200 0.3621952 94s [568] 0.4610877 0.5408090 0.3763389 0.5653200 0.4610877 0.3763389 0.3621952 94s [575] 0.5408090 0.4610877 0.4716508 0.3763389 0.3621952 0.4610877 0.5653200 94s [582] 0.5408090 0.3621952 0.3763389 0.4716508 0.4610877 0.3621952 0.3763389 94s [589] 0.4716508 94s 94s [1] 64.48518 94s [1] 3722.867 94s [1] 3722.867 94s Dose Response Model 94s 94s Model: betaMod 94s Fit-type: normal 94s 94s Residuals: 94s Min 1Q Median 3Q Max 94s -23.081 -4.023 0.069 3.767 16.317 94s 94s Coefficients with approx. stand. error: 94s Estimate Std. Error 94s e0 1.02e+01 0.82024 94s eMax 7.36e+00 0.69530 94s delta1 2.25e+00 0.60058 94s delta2 1.01e+00 0.33271 94s age 5.72e-04 0.00829 94s centergreen 7.41e-01 0.73739 94s centerred 8.30e-01 0.74509 94s centersilver 7.30e-01 0.70097 94s centeryellow 6.56e-01 0.73274 94s 94s Residual standard error: 5.65 94s Degrees of freedom: 580 94s 94s Formula: y ~ cbind(XX, betaMod(x, 0, 1, delta1, delta2, scl)) 94s 94s Parameters: 94s Estimate Std. Error t value Pr(>|t|) 94s delta1 2.253e+00 6.006e-01 3.751 0.000194 *** 94s delta2 1.006e+00 3.327e-01 3.025 0.002600 ** 94s .lin.(Intercept) 1.023e+01 8.202e-01 12.470 < 2e-16 *** 94s .lin.centergreen 7.409e-01 7.374e-01 1.005 0.315410 94s .lin.centerred 8.298e-01 7.451e-01 1.114 0.265866 94s .lin.centersilver 7.301e-01 7.010e-01 1.042 0.298051 94s .lin.centeryellow 6.562e-01 7.327e-01 0.896 0.370886 94s .lin.age 5.723e-04 8.288e-03 0.069 0.944970 94s .lin7 7.357e+00 6.953e-01 10.581 < 2e-16 *** 94s --- 94s Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 94s 94s Residual standard error: 5.653 on 580 degrees of freedom 94s 94s Number of iterations to convergence: 6 94s Achieved convergence tolerance: 9.472e-06 94s 94s e0 eMax delta1 delta2 94s e0 0.672788555 -0.2729452009 2.029556e-01 8.893435e-02 94s eMax -0.272945201 0.4834404097 -4.411253e-02 1.212204e-02 94s delta1 0.202955602 -0.0441125316 3.606932e-01 1.869163e-01 94s delta2 0.088934352 0.0121220371 1.869163e-01 1.106931e-01 94s age -0.003530727 0.0001030079 4.984077e-05 7.767012e-05 94s centergreen -0.234450342 -0.0348602441 1.207912e-02 1.405608e-03 94s centerred -0.253662862 -0.0121021695 6.628052e-04 -2.474391e-03 94s centersilver -0.222055302 -0.0379891034 1.347032e-02 4.810797e-03 94s centeryellow -0.242096858 -0.0036488338 1.244170e-02 2.099443e-03 94s age centergreen centerred centersilver 94s e0 -3.530727e-03 -0.2344503416 -0.2536628616 -2.220553e-01 94s eMax 1.030079e-04 -0.0348602441 -0.0121021695 -3.798910e-02 94s delta1 4.984077e-05 0.0120791216 0.0006628052 1.347032e-02 94s delta2 7.767012e-05 0.0014056079 -0.0024743906 4.810797e-03 94s age 6.868689e-05 0.0001513555 0.0001912581 -2.484136e-05 94s centergreen 1.513555e-04 0.5437481113 0.2513884520 2.524566e-01 94s centerred 1.912581e-04 0.2513884520 0.5551521388 2.504165e-01 94s centersilver -2.484136e-05 0.2524565639 0.2504164883 4.913597e-01 94s centeryellow -1.767809e-05 0.2510775793 0.2504115027 2.500668e-01 94s centeryellow 94s e0 -2.420969e-01 94s eMax -3.648834e-03 94s delta1 1.244170e-02 94s delta2 2.099443e-03 94s age -1.767809e-05 94s centergreen 2.510776e-01 94s centerred 2.504115e-01 94s centersilver 2.500668e-01 94s centeryellow 5.369021e-01 94s delta1 delta2 .lin.(Intercept) .lin.centergreen 94s delta1 3.606961e-01 1.869176e-01 0.202956171 0.0120792615 94s delta2 1.869176e-01 1.106938e-01 0.088934648 0.0014056742 94s .lin.(Intercept) 2.029562e-01 8.893465e-02 0.672787602 -0.2344503743 94s .lin.centergreen 1.207926e-02 1.405674e-03 -0.234450374 0.5437481112 94s .lin.centerred 6.627065e-04 -2.474441e-03 -0.253662951 0.2513884457 94s .lin.centersilver 1.347037e-02 4.810825e-03 -0.222055391 0.2524565593 94s .lin.centeryellow 1.244156e-02 2.099363e-03 -0.242097015 0.2510775716 94s .lin.age 4.984142e-05 7.767047e-05 -0.003530726 0.0001513556 94s .lin7 -4.411231e-02 1.212224e-02 -0.272944309 -0.0348602205 94s .lin.centerred .lin.centersilver .lin.centeryellow 94s delta1 0.0006627065 1.347037e-02 1.244156e-02 94s delta2 -0.0024744413 4.810825e-03 2.099363e-03 94s .lin.(Intercept) -0.2536629506 -2.220554e-01 -2.420970e-01 94s .lin.centergreen 0.2513884457 2.524566e-01 2.510776e-01 94s .lin.centerred 0.5551521364 2.504165e-01 2.504115e-01 94s .lin.centersilver 0.2504164813 4.913597e-01 2.500668e-01 94s .lin.centeryellow 0.2504114958 2.500668e-01 5.369021e-01 94s .lin.age 0.0001912581 -2.484131e-05 -1.767806e-05 94s .lin7 -0.0121021533 -3.798904e-02 -3.648777e-03 94s .lin.age .lin7 94s delta1 4.984142e-05 -0.0441123055 94s delta2 7.767047e-05 0.0121222432 94s .lin.(Intercept) -3.530726e-03 -0.2729443093 94s .lin.centergreen 1.513556e-04 -0.0348602205 94s .lin.centerred 1.912581e-04 -0.0121021533 94s .lin.centersilver -2.484131e-05 -0.0379890373 94s .lin.centeryellow -1.767806e-05 -0.0036487770 94s .lin.age 6.868689e-05 0.0001030081 94s .lin7 1.030081e-04 0.4834404337 94s $fit 94s [1] 0.000000 2.289162 94s 94s $se.fit 94s [1] 0.0000000 0.7519464 94s 94s $fit 94s [1] 10.91275 13.20191 94s 94s $se.fit 94s [1] 0.7364602 0.6423551 94s 94s [1] 65.39866 94s [1] -485.5937 94s [1] -485.5937 94s Dose Response Model 94s 94s Model: emax 94s Fit-type: normal 94s 94s Residuals: 94s Min 1Q Median 3Q Max 94s -0.0666 -0.0180 -0.0011 0.0193 0.0692 94s 94s Coefficients with approx. stand. error: 94s Estimate Std. Error 94s e0 -0.5830 6.00e-03 94s eMax 0.0163 3.36e-02 94s ed50 286.5994 1.91e+03 94s 94s Residual standard error: 0.0281 94s Degrees of freedom: 111 94s 94s Formula: y ~ emax(x, e0, emax, ed50) 94s 94s Parameters: 94s Estimate Std. Error t value Pr(>|t|) 94s e0 -0.58297 0.00600 -97.164 <2e-16 *** 94s emax 0.01632 0.03356 0.486 0.628 94s ed50 286.45918 1905.11276 0.150 0.881 94s --- 94s Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 94s 94s Residual standard error: 0.02814 on 111 degrees of freedom 94s 94s Number of iterations to convergence: 8 94s Achieved convergence tolerance: 9.607e-06 94s 94s e0 eMax ed50 94s e0 3.599786e-05 -2.913476e-05 1.313843e+00 94s eMax -2.913476e-05 1.126946e-03 6.130311e+01 94s ed50 1.313843e+00 6.130311e+01 3.631673e+06 94s e0 emax ed50 94s e0 3.599786e-05 -2.914142e-05 1.313001e+00 94s emax -2.914142e-05 1.126323e-03 6.126673e+01 94s ed50 1.313001e+00 6.126673e+01 3.629455e+06 94s $fit 94s [1] 0.01155472 0.01155472 0.00000000 0.01155472 0.01155472 0.01155472 94s [7] 0.01056820 0.01056820 0.01056820 0.01155472 0.01239306 0.01056820 94s [13] 0.00000000 0.01239306 0.01155472 0.01056820 0.01056820 0.00000000 94s [19] 0.01155472 0.01212084 0.01212084 0.01056820 0.00000000 0.01155472 94s [25] 0.01056820 0.01056820 0.01155472 0.00000000 0.00000000 0.01155472 94s [31] 0.01056820 0.01155472 0.01056820 0.01056820 0.00000000 0.01056820 94s [37] 0.01155472 0.01212084 0.00000000 0.01155472 0.01239306 0.01155472 94s [43] 0.01056820 0.01056820 0.01155472 0.01155472 0.01155472 0.00000000 94s [49] 0.01155472 0.01056820 0.01056820 0.00000000 0.01056820 0.01239306 94s [55] 0.00000000 0.01056820 0.01155472 0.01056820 0.01239306 0.01239306 94s [61] 0.01056820 0.01239306 0.01056820 0.01155472 0.01212084 0.01155472 94s [67] 0.01056820 0.01056820 0.01239306 0.01056820 0.00000000 0.01155472 94s [73] 0.01239306 0.01155472 0.01155472 0.01056820 0.00000000 0.00000000 94s [79] 0.01155472 0.00000000 0.00000000 0.00000000 0.01155472 0.01155472 94s [85] 0.01056820 0.01056820 0.01155472 0.01056820 0.01155472 0.01155472 94s [91] 0.01212084 0.01155472 0.01212084 0.01056820 0.00000000 0.01155472 94s [97] 0.01155472 0.01056820 0.01155472 0.00000000 0.01155472 0.01155472 94s [103] 0.01056820 0.01056820 0.01056820 0.00000000 0.01155472 0.00000000 94s [109] 0.01056820 0.01056820 0.01155472 0.01056820 0.00000000 0.01056820 94s 94s $se.fit 94s [1] 0.006800657 0.006800657 0.000000000 0.006800657 0.006800657 0.006800657 94s [7] 0.007368990 0.007368990 0.007368990 0.006800657 0.008598392 0.007368990 94s [13] 0.000000000 0.008598392 0.006800657 0.007368990 0.007368990 0.000000000 94s [19] 0.006800657 0.007779856 0.007779856 0.007368990 0.000000000 0.006800657 94s [25] 0.007368990 0.007368990 0.006800657 0.000000000 0.000000000 0.006800657 94s [31] 0.007368990 0.006800657 0.007368990 0.007368990 0.000000000 0.007368990 94s [37] 0.006800657 0.007779856 0.000000000 0.006800657 0.008598392 0.006800657 94s [43] 0.007368990 0.007368990 0.006800657 0.006800657 0.006800657 0.000000000 94s [49] 0.006800657 0.007368990 0.007368990 0.000000000 0.007368990 0.008598392 94s [55] 0.000000000 0.007368990 0.006800657 0.007368990 0.008598392 0.008598392 94s [61] 0.007368990 0.008598392 0.007368990 0.006800657 0.007779856 0.006800657 94s [67] 0.007368990 0.007368990 0.008598392 0.007368990 0.000000000 0.006800657 94s [73] 0.008598392 0.006800657 0.006800657 0.007368990 0.000000000 0.000000000 94s [79] 0.006800657 0.000000000 0.000000000 0.000000000 0.006800657 0.006800657 94s [85] 0.007368990 0.007368990 0.006800657 0.007368990 0.006800657 0.006800657 94s [91] 0.007779856 0.006800657 0.007779856 0.007368990 0.000000000 0.006800657 94s [97] 0.006800657 0.007368990 0.006800657 0.000000000 0.006800657 0.006800657 94s [103] 0.007368990 0.007368990 0.007368990 0.000000000 0.006800657 0.000000000 94s [109] 0.007368990 0.007368990 0.006800657 0.007368990 0.000000000 0.007368990 94s 94s $fit 94s [1] -0.5714146 -0.5714146 -0.5829694 -0.5714146 -0.5714146 -0.5714146 94s [7] -0.5724012 -0.5724012 -0.5724012 -0.5714146 -0.5705763 -0.5724012 94s [13] -0.5829694 -0.5705763 -0.5714146 -0.5724012 -0.5724012 -0.5829694 94s [19] -0.5714146 -0.5708485 -0.5708485 -0.5724012 -0.5829694 -0.5714146 94s [25] -0.5724012 -0.5724012 -0.5714146 -0.5829694 -0.5829694 -0.5714146 94s [31] -0.5724012 -0.5714146 -0.5724012 -0.5724012 -0.5829694 -0.5724012 94s [37] -0.5714146 -0.5708485 -0.5829694 -0.5714146 -0.5705763 -0.5714146 94s [43] -0.5724012 -0.5724012 -0.5714146 -0.5714146 -0.5714146 -0.5829694 94s [49] -0.5714146 -0.5724012 -0.5724012 -0.5829694 -0.5724012 -0.5705763 94s [55] -0.5829694 -0.5724012 -0.5714146 -0.5724012 -0.5705763 -0.5705763 94s [61] -0.5724012 -0.5705763 -0.5724012 -0.5714146 -0.5708485 -0.5714146 94s [67] -0.5724012 -0.5724012 -0.5705763 -0.5724012 -0.5829694 -0.5714146 94s [73] -0.5705763 -0.5714146 -0.5714146 -0.5724012 -0.5829694 -0.5829694 94s [79] -0.5714146 -0.5829694 -0.5829694 -0.5829694 -0.5714146 -0.5714146 94s [85] -0.5724012 -0.5724012 -0.5714146 -0.5724012 -0.5714146 -0.5714146 94s [91] -0.5708485 -0.5714146 -0.5708485 -0.5724012 -0.5829694 -0.5714146 94s [97] -0.5714146 -0.5724012 -0.5714146 -0.5829694 -0.5714146 -0.5714146 94s [103] -0.5724012 -0.5724012 -0.5724012 -0.5829694 -0.5714146 -0.5829694 94s [109] -0.5724012 -0.5724012 -0.5714146 -0.5724012 -0.5829694 -0.5724012 94s 94s $se.fit 94s [1] 0.003169353 0.003169353 0.005999821 0.003169353 0.003169353 0.003169353 94s [7] 0.004290400 0.004290400 0.004290400 0.003169353 0.006190654 0.004290400 94s [13] 0.005999821 0.006190654 0.003169353 0.004290400 0.004290400 0.005999821 94s [19] 0.003169353 0.004963663 0.004963663 0.004290400 0.005999821 0.003169353 94s [25] 0.004290400 0.004290400 0.003169353 0.005999821 0.005999821 0.003169353 94s [31] 0.004290400 0.003169353 0.004290400 0.004290400 0.005999821 0.004290400 94s [37] 0.003169353 0.004963663 0.005999821 0.003169353 0.006190654 0.003169353 94s [43] 0.004290400 0.004290400 0.003169353 0.003169353 0.003169353 0.005999821 94s [49] 0.003169353 0.004290400 0.004290400 0.005999821 0.004290400 0.006190654 94s [55] 0.005999821 0.004290400 0.003169353 0.004290400 0.006190654 0.006190654 94s [61] 0.004290400 0.006190654 0.004290400 0.003169353 0.004963663 0.003169353 94s [67] 0.004290400 0.004290400 0.006190654 0.004290400 0.005999821 0.003169353 94s [73] 0.006190654 0.003169353 0.003169353 0.004290400 0.005999821 0.005999821 94s [79] 0.003169353 0.005999821 0.005999821 0.005999821 0.003169353 0.003169353 94s [85] 0.004290400 0.004290400 0.003169353 0.004290400 0.003169353 0.003169353 94s [91] 0.004963663 0.003169353 0.004963663 0.004290400 0.005999821 0.003169353 94s [97] 0.003169353 0.004290400 0.003169353 0.005999821 0.003169353 0.003169353 94s [103] 0.004290400 0.004290400 0.004290400 0.005999821 0.003169353 0.005999821 94s [109] 0.004290400 0.004290400 0.003169353 0.004290400 0.005999821 0.004290400 94s 94s [1] 126.5178 95s [1] -481.376 95s [1] -481.378 95s Dose Response Model 95s 95s Model: emax 95s Fit-type: normal 95s 95s Residuals: 95s Min 1Q Median 3Q Max 95s -0.07408 -0.01641 -0.00232 0.01807 0.07476 95s 95s Coefficients with approx. stand. error: 95s Estimate Std. Error 95s e0 -5.81e-01 8.97e-03 95s eMax 2.93e-02 9.13e-02 95s ed50 9.03e+02 5.00e+03 95s age -1.22e-04 1.06e-04 95s centergreen 1.07e-02 8.31e-03 95s centerred 9.27e-03 7.73e-03 95s centersilver 1.22e-03 8.91e-03 95s centeryellow -4.65e-03 8.50e-03 95s 95s Residual standard error: 0.0281 95s Degrees of freedom: 106 95s 95s Formula: y ~ cbind(XX, emax(x, 0, 1, ed50)) 95s 95s Parameters: 95s Estimate Std. Error t value Pr(>|t|) 95s ed50 1.111e+03 6.451e+03 0.172 0.864 95s .lin.(Intercept) -5.813e-01 8.970e-03 -64.810 <2e-16 *** 95s .lin.centergreen 1.071e-02 8.309e-03 1.288 0.200 95s .lin.centerred 9.301e-03 7.726e-03 1.204 0.231 95s .lin.centersilver 1.196e-03 8.915e-03 0.134 0.894 95s .lin.centeryellow -4.665e-03 8.497e-03 -0.549 0.584 95s .lin.age -1.213e-04 1.057e-04 -1.148 0.254 95s .lin7 3.300e-02 1.170e-01 0.282 0.778 95s --- 95s Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 95s 95s Residual standard error: 0.02808 on 106 degrees of freedom 95s 95s Number of iterations to convergence: 9 95s Achieved convergence tolerance: 7.028e-06 95s 95s e0 eMax ed50 age 95s e0 8.046543e-05 -3.844545e-05 2.355425e+00 -4.980066e-07 95s eMax -3.844545e-05 8.342573e-03 4.493061e+02 1.107091e-06 95s ed50 2.355425e+00 4.493061e+02 2.497229e+07 6.444381e-02 95s age -4.980066e-07 1.107091e-06 6.444381e-02 1.116195e-08 95s centergreen -1.978501e-05 6.446464e-05 4.524614e+00 -8.645567e-08 95s centerred -3.432079e-05 7.922237e-05 3.670388e+00 1.157010e-08 95s centersilver -1.753629e-05 -7.656779e-05 -3.796015e+00 -2.309374e-07 95s centeryellow -3.332560e-05 -5.044361e-05 -2.141277e+00 1.346886e-07 95s centergreen centerred centersilver centeryellow 95s e0 -1.978501e-05 -3.432079e-05 -1.753629e-05 -3.332560e-05 95s eMax 6.446464e-05 7.922237e-05 -7.656779e-05 -5.044361e-05 95s ed50 4.524614e+00 3.670388e+00 -3.796015e+00 -2.141277e+00 95s age -8.645567e-08 1.157010e-08 -2.309374e-07 1.346886e-07 95s centergreen 6.902160e-05 3.007695e-05 3.223410e-05 2.943878e-05 95s centerred 3.007695e-05 5.968790e-05 2.924362e-05 2.945739e-05 95s centersilver 3.223410e-05 2.924362e-05 7.947639e-05 2.823145e-05 95s centeryellow 2.943878e-05 2.945739e-05 2.823145e-05 7.219729e-05 95s ed50 .lin.(Intercept) .lin.centergreen 95s ed50 4.162109e+07 3.618133e+00 6.072527e+00 95s .lin.(Intercept) 3.618133e+00 8.045192e-05 -1.978784e-05 95s .lin.centergreen 6.072527e+00 -1.978784e-05 6.904772e-05 95s .lin.centerred 4.627132e+00 -3.432899e-05 3.008663e-05 95s .lin.centersilver -4.847154e+00 -1.752828e-05 3.222029e-05 95s .lin.centeryellow -2.727240e+00 -3.332482e-05 2.942341e-05 95s .lin.age 8.505295e-02 -4.980346e-07 -8.605363e-08 95s .lin7 7.456212e+02 -2.614221e-05 9.001668e-05 95s .lin.centerred .lin.centersilver .lin.centeryellow 95s ed50 4.627132e+00 -4.847154e+00 -2.727240e+00 95s .lin.(Intercept) -3.432899e-05 -1.752828e-05 -3.332482e-05 95s .lin.centergreen 3.008663e-05 3.222029e-05 2.942341e-05 95s .lin.centerred 5.968601e-05 2.924192e-05 2.945040e-05 95s .lin.centersilver 2.924192e-05 7.947836e-05 2.823890e-05 95s .lin.centeryellow 2.945040e-05 2.823890e-05 7.220391e-05 95s .lin.age 1.172543e-08 -2.311322e-07 1.344697e-07 95s .lin7 9.802604e-05 -9.643580e-05 -6.245218e-05 95s .lin.age .lin7 95s ed50 8.505295e-02 7.456212e+02 95s .lin.(Intercept) -4.980346e-07 -2.614221e-05 95s .lin.centergreen -8.605363e-08 9.001668e-05 95s .lin.centerred 1.172543e-08 9.802604e-05 95s .lin.centersilver -2.311322e-07 -9.643580e-05 95s .lin.centeryellow 1.344697e-07 -6.245218e-05 95s .lin.age 1.116761e-08 1.469361e-06 95s .lin7 1.469361e-06 1.368628e-02 95s $fit 95s [1] 0.000000000 0.002916944 95s 95s $se.fit 95s [1] 0.000000 0.005795 95s 95s $fit 95s [1] -0.5861913 -0.5832744 95s 95s $se.fit 95s [1] 0.008937545 0.009550033 95s 95s [1] 186.1323 95s [1] 2049.321 95s [1] 2049.321 95s Dose Response Model 95s 95s Model: sigEmax 95s Fit-type: normal 95s 95s Residuals: 95s Min 1Q Median 3Q Max 95s -13.6383 -2.8339 0.0791 3.0983 10.5294 95s 95s Coefficients with approx. stand. error: 95s Estimate Std. Error 95s e0 -10.92 0.555 95s eMax 17.17 3.430 95s ed50 379.22 148.679 95s h 1.38 0.349 95s 95s Residual standard error: 4.37 95s Degrees of freedom: 349 95s 95s Formula: y ~ sigEmax(x, e0, emax, ed50, h) 95s 95s Parameters: 95s Estimate Std. Error t value Pr(>|t|) 95s e0 -10.9166 0.5552 -19.664 < 2e-16 *** 95s emax 17.1659 3.4296 5.005 8.87e-07 *** 95s ed50 379.2177 148.6773 2.551 0.0112 * 95s h 1.3754 0.3490 3.941 9.81e-05 *** 95s --- 95s Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 95s 95s Residual standard error: 4.372 on 349 degrees of freedom 95s 95s Number of iterations to convergence: 4 95s Achieved convergence tolerance: 7.009e-07 95s 95s e0 eMax ed50 h 95s e0 0.30821303 -0.518459 6.111486 0.06026433 95s eMax -0.51845900 11.762553 468.796873 -1.10430569 95s ed50 6.11148634 468.796873 22105.397044 -40.29692787 95s h 0.06026433 -1.104306 -40.296928 0.12181039 95s e0 emax ed50 h 95s e0 0.30821303 -0.5184566 6.111568 0.06026447 95s emax -0.51845655 11.7623435 468.787156 -1.10429851 95s ed50 6.11156813 468.7871558 22104.941251 -40.29652562 95s h 0.06026447 -1.1042985 -40.296526 0.12181099 95s $fit 95s [1] 12.497935 12.497935 13.842361 2.869998 13.842361 13.842361 0.000000 95s [8] 0.000000 13.842361 2.869998 12.497935 12.497935 11.114421 12.497935 95s [15] 12.497935 12.497935 12.497935 12.497935 0.000000 12.497935 12.497935 95s [22] 0.000000 13.842361 13.842361 0.000000 0.000000 2.869998 12.497935 95s [29] 2.869998 2.869998 13.842361 0.000000 11.114421 12.497935 0.000000 95s [36] 13.842361 13.842361 12.497935 13.842361 2.869998 12.497935 12.497935 95s [43] 12.497935 2.869998 12.497935 12.497935 11.114421 12.497935 13.842361 95s [50] 13.842361 12.497935 0.000000 12.497935 12.497935 0.000000 12.497935 95s [57] 0.000000 13.842361 12.497935 2.869998 12.497935 13.842361 12.497935 95s [64] 13.842361 13.842361 12.497935 12.497935 2.869998 12.497935 2.869998 95s [71] 12.497935 2.869998 12.497935 12.497935 0.000000 13.842361 0.000000 95s [78] 13.842361 12.497935 12.497935 12.497935 12.497935 13.842361 2.869998 95s [85] 12.497935 12.497935 12.497935 0.000000 0.000000 0.000000 0.000000 95s [92] 2.869998 12.497935 12.497935 2.869998 12.497935 12.497935 2.869998 95s [99] 12.497935 0.000000 12.497935 0.000000 2.869998 2.869998 2.869998 95s [106] 12.497935 13.842361 12.497935 2.869998 0.000000 13.842361 2.869998 95s [113] 12.497935 0.000000 12.497935 0.000000 13.842361 12.497935 0.000000 95s [120] 12.497935 11.114421 13.842361 12.497935 12.497935 0.000000 12.497935 95s [127] 2.869998 13.842361 12.497935 13.842361 12.497935 2.869998 12.497935 95s [134] 12.497935 12.497935 12.497935 12.497935 13.842361 13.842361 0.000000 95s [141] 11.114421 12.497935 0.000000 12.497935 13.842361 12.497935 11.114421 95s [148] 12.497935 0.000000 0.000000 2.869998 13.842361 0.000000 2.869998 95s [155] 13.842361 2.869998 11.114421 11.114421 12.497935 0.000000 12.497935 95s [162] 12.497935 2.869998 2.869998 12.497935 12.497935 12.497935 12.497935 95s [169] 2.869998 11.114421 0.000000 13.842361 12.497935 11.114421 12.497935 95s [176] 13.842361 13.842361 12.497935 12.497935 12.497935 12.497935 12.497935 95s [183] 2.869998 13.842361 0.000000 12.497935 12.497935 12.497935 2.869998 95s [190] 13.842361 12.497935 13.842361 2.869998 13.842361 12.497935 12.497935 95s [197] 12.497935 0.000000 11.114421 2.869998 12.497935 2.869998 12.497935 95s [204] 0.000000 12.497935 13.842361 12.497935 13.842361 12.497935 2.869998 95s [211] 2.869998 12.497935 13.842361 13.842361 2.869998 0.000000 13.842361 95s [218] 12.497935 12.497935 0.000000 13.842361 12.497935 12.497935 0.000000 95s [225] 13.842361 11.114421 12.497935 2.869998 12.497935 0.000000 12.497935 95s [232] 12.497935 13.842361 0.000000 12.497935 12.497935 13.842361 0.000000 95s [239] 13.842361 13.842361 12.497935 13.842361 0.000000 2.869998 12.497935 95s [246] 13.842361 12.497935 12.497935 13.842361 2.869998 0.000000 0.000000 95s [253] 11.114421 2.869998 12.497935 2.869998 13.842361 0.000000 12.497935 95s [260] 12.497935 12.497935 12.497935 11.114421 0.000000 0.000000 0.000000 95s [267] 0.000000 0.000000 0.000000 12.497935 13.842361 13.842361 2.869998 95s [274] 12.497935 12.497935 12.497935 2.869998 13.842361 12.497935 13.842361 95s [281] 12.497935 12.497935 12.497935 12.497935 2.869998 13.842361 12.497935 95s [288] 11.114421 0.000000 12.497935 12.497935 0.000000 2.869998 12.497935 95s [295] 0.000000 0.000000 13.842361 0.000000 12.497935 13.842361 12.497935 95s [302] 12.497935 13.842361 12.497935 12.497935 2.869998 12.497935 2.869998 95s [309] 11.114421 2.869998 2.869998 0.000000 13.842361 0.000000 12.497935 95s [316] 2.869998 13.842361 0.000000 13.842361 11.114421 12.497935 0.000000 95s [323] 12.497935 12.497935 0.000000 13.842361 13.842361 13.842361 13.842361 95s [330] 11.114421 2.869998 0.000000 12.497935 0.000000 12.497935 13.842361 95s [337] 12.497935 12.497935 12.497935 12.497935 12.497935 13.842361 12.497935 95s [344] 2.869998 13.842361 13.842361 2.869998 11.114421 2.869998 12.497935 95s [351] 12.497935 12.497935 13.842361 95s 95s $se.fit 95s [1] 0.6365415 0.6365415 0.7457881 0.8126372 0.7457881 0.7457881 0.0000000 95s [8] 0.0000000 0.7457881 0.8126372 0.6365415 0.6365415 0.8003756 0.6365415 95s [15] 0.6365415 0.6365415 0.6365415 0.6365415 0.0000000 0.6365415 0.6365415 95s [22] 0.0000000 0.7457881 0.7457881 0.0000000 0.0000000 0.8126372 0.6365415 95s [29] 0.8126372 0.8126372 0.7457881 0.0000000 0.8003756 0.6365415 0.0000000 95s [36] 0.7457881 0.7457881 0.6365415 0.7457881 0.8126372 0.6365415 0.6365415 95s [43] 0.6365415 0.8126372 0.6365415 0.6365415 0.8003756 0.6365415 0.7457881 95s [50] 0.7457881 0.6365415 0.0000000 0.6365415 0.6365415 0.0000000 0.6365415 95s [57] 0.0000000 0.7457881 0.6365415 0.8126372 0.6365415 0.7457881 0.6365415 95s [64] 0.7457881 0.7457881 0.6365415 0.6365415 0.8126372 0.6365415 0.8126372 95s [71] 0.6365415 0.8126372 0.6365415 0.6365415 0.0000000 0.7457881 0.0000000 95s [78] 0.7457881 0.6365415 0.6365415 0.6365415 0.6365415 0.7457881 0.8126372 95s [85] 0.6365415 0.6365415 0.6365415 0.0000000 0.0000000 0.0000000 0.0000000 95s [92] 0.8126372 0.6365415 0.6365415 0.8126372 0.6365415 0.6365415 0.8126372 95s [99] 0.6365415 0.0000000 0.6365415 0.0000000 0.8126372 0.8126372 0.8126372 95s [106] 0.6365415 0.7457881 0.6365415 0.8126372 0.0000000 0.7457881 0.8126372 95s [113] 0.6365415 0.0000000 0.6365415 0.0000000 0.7457881 0.6365415 0.0000000 95s [120] 0.6365415 0.8003756 0.7457881 0.6365415 0.6365415 0.0000000 0.6365415 95s [127] 0.8126372 0.7457881 0.6365415 0.7457881 0.6365415 0.8126372 0.6365415 95s [134] 0.6365415 0.6365415 0.6365415 0.6365415 0.7457881 0.7457881 0.0000000 95s [141] 0.8003756 0.6365415 0.0000000 0.6365415 0.7457881 0.6365415 0.8003756 95s [148] 0.6365415 0.0000000 0.0000000 0.8126372 0.7457881 0.0000000 0.8126372 95s [155] 0.7457881 0.8126372 0.8003756 0.8003756 0.6365415 0.0000000 0.6365415 95s [162] 0.6365415 0.8126372 0.8126372 0.6365415 0.6365415 0.6365415 0.6365415 95s [169] 0.8126372 0.8003756 0.0000000 0.7457881 0.6365415 0.8003756 0.6365415 95s [176] 0.7457881 0.7457881 0.6365415 0.6365415 0.6365415 0.6365415 0.6365415 95s [183] 0.8126372 0.7457881 0.0000000 0.6365415 0.6365415 0.6365415 0.8126372 95s [190] 0.7457881 0.6365415 0.7457881 0.8126372 0.7457881 0.6365415 0.6365415 95s [197] 0.6365415 0.0000000 0.8003756 0.8126372 0.6365415 0.8126372 0.6365415 95s [204] 0.0000000 0.6365415 0.7457881 0.6365415 0.7457881 0.6365415 0.8126372 95s [211] 0.8126372 0.6365415 0.7457881 0.7457881 0.8126372 0.0000000 0.7457881 95s [218] 0.6365415 0.6365415 0.0000000 0.7457881 0.6365415 0.6365415 0.0000000 95s [225] 0.7457881 0.8003756 0.6365415 0.8126372 0.6365415 0.0000000 0.6365415 95s [232] 0.6365415 0.7457881 0.0000000 0.6365415 0.6365415 0.7457881 0.0000000 95s [239] 0.7457881 0.7457881 0.6365415 0.7457881 0.0000000 0.8126372 0.6365415 95s [246] 0.7457881 0.6365415 0.6365415 0.7457881 0.8126372 0.0000000 0.0000000 95s [253] 0.8003756 0.8126372 0.6365415 0.8126372 0.7457881 0.0000000 0.6365415 95s [260] 0.6365415 0.6365415 0.6365415 0.8003756 0.0000000 0.0000000 0.0000000 95s [267] 0.0000000 0.0000000 0.0000000 0.6365415 0.7457881 0.7457881 0.8126372 95s [274] 0.6365415 0.6365415 0.6365415 0.8126372 0.7457881 0.6365415 0.7457881 95s [281] 0.6365415 0.6365415 0.6365415 0.6365415 0.8126372 0.7457881 0.6365415 95s [288] 0.8003756 0.0000000 0.6365415 0.6365415 0.0000000 0.8126372 0.6365415 95s [295] 0.0000000 0.0000000 0.7457881 0.0000000 0.6365415 0.7457881 0.6365415 95s [302] 0.6365415 0.7457881 0.6365415 0.6365415 0.8126372 0.6365415 0.8126372 95s [309] 0.8003756 0.8126372 0.8126372 0.0000000 0.7457881 0.0000000 0.6365415 95s [316] 0.8126372 0.7457881 0.0000000 0.7457881 0.8003756 0.6365415 0.0000000 95s [323] 0.6365415 0.6365415 0.0000000 0.7457881 0.7457881 0.7457881 0.7457881 95s [330] 0.8003756 0.8126372 0.0000000 0.6365415 0.0000000 0.6365415 0.7457881 95s [337] 0.6365415 0.6365415 0.6365415 0.6365415 0.6365415 0.7457881 0.6365415 95s [344] 0.8126372 0.7457881 0.7457881 0.8126372 0.8003756 0.8126372 0.6365415 95s [351] 0.6365415 0.6365415 0.7457881 95s 95s $fit 95s [1] 1.5813420 1.5813420 2.9257679 -8.0465953 2.9257679 2.9257679 95s [7] -10.9165932 -10.9165932 2.9257679 -8.0465953 1.5813420 1.5813420 95s [13] 0.1978277 1.5813420 1.5813420 1.5813420 1.5813420 1.5813420 95s [19] -10.9165932 1.5813420 1.5813420 -10.9165932 2.9257679 2.9257679 95s [25] -10.9165932 -10.9165932 -8.0465953 1.5813420 -8.0465953 -8.0465953 95s [31] 2.9257679 -10.9165932 0.1978277 1.5813420 -10.9165932 2.9257679 95s [37] 2.9257679 1.5813420 2.9257679 -8.0465953 1.5813420 1.5813420 95s [43] 1.5813420 -8.0465953 1.5813420 1.5813420 0.1978277 1.5813420 95s [49] 2.9257679 2.9257679 1.5813420 -10.9165932 1.5813420 1.5813420 95s [55] -10.9165932 1.5813420 -10.9165932 2.9257679 1.5813420 -8.0465953 95s [61] 1.5813420 2.9257679 1.5813420 2.9257679 2.9257679 1.5813420 95s [67] 1.5813420 -8.0465953 1.5813420 -8.0465953 1.5813420 -8.0465953 95s [73] 1.5813420 1.5813420 -10.9165932 2.9257679 -10.9165932 2.9257679 95s [79] 1.5813420 1.5813420 1.5813420 1.5813420 2.9257679 -8.0465953 95s [85] 1.5813420 1.5813420 1.5813420 -10.9165932 -10.9165932 -10.9165932 95s [91] -10.9165932 -8.0465953 1.5813420 1.5813420 -8.0465953 1.5813420 95s [97] 1.5813420 -8.0465953 1.5813420 -10.9165932 1.5813420 -10.9165932 95s [103] -8.0465953 -8.0465953 -8.0465953 1.5813420 2.9257679 1.5813420 95s [109] -8.0465953 -10.9165932 2.9257679 -8.0465953 1.5813420 -10.9165932 95s [115] 1.5813420 -10.9165932 2.9257679 1.5813420 -10.9165932 1.5813420 95s [121] 0.1978277 2.9257679 1.5813420 1.5813420 -10.9165932 1.5813420 95s [127] -8.0465953 2.9257679 1.5813420 2.9257679 1.5813420 -8.0465953 95s [133] 1.5813420 1.5813420 1.5813420 1.5813420 1.5813420 2.9257679 95s [139] 2.9257679 -10.9165932 0.1978277 1.5813420 -10.9165932 1.5813420 95s [145] 2.9257679 1.5813420 0.1978277 1.5813420 -10.9165932 -10.9165932 95s [151] -8.0465953 2.9257679 -10.9165932 -8.0465953 2.9257679 -8.0465953 95s [157] 0.1978277 0.1978277 1.5813420 -10.9165932 1.5813420 1.5813420 95s [163] -8.0465953 -8.0465953 1.5813420 1.5813420 1.5813420 1.5813420 95s [169] -8.0465953 0.1978277 -10.9165932 2.9257679 1.5813420 0.1978277 95s [175] 1.5813420 2.9257679 2.9257679 1.5813420 1.5813420 1.5813420 95s [181] 1.5813420 1.5813420 -8.0465953 2.9257679 -10.9165932 1.5813420 95s [187] 1.5813420 1.5813420 -8.0465953 2.9257679 1.5813420 2.9257679 95s [193] -8.0465953 2.9257679 1.5813420 1.5813420 1.5813420 -10.9165932 95s [199] 0.1978277 -8.0465953 1.5813420 -8.0465953 1.5813420 -10.9165932 95s [205] 1.5813420 2.9257679 1.5813420 2.9257679 1.5813420 -8.0465953 95s [211] -8.0465953 1.5813420 2.9257679 2.9257679 -8.0465953 -10.9165932 95s [217] 2.9257679 1.5813420 1.5813420 -10.9165932 2.9257679 1.5813420 95s [223] 1.5813420 -10.9165932 2.9257679 0.1978277 1.5813420 -8.0465953 95s [229] 1.5813420 -10.9165932 1.5813420 1.5813420 2.9257679 -10.9165932 95s [235] 1.5813420 1.5813420 2.9257679 -10.9165932 2.9257679 2.9257679 95s [241] 1.5813420 2.9257679 -10.9165932 -8.0465953 1.5813420 2.9257679 95s [247] 1.5813420 1.5813420 2.9257679 -8.0465953 -10.9165932 -10.9165932 95s [253] 0.1978277 -8.0465953 1.5813420 -8.0465953 2.9257679 -10.9165932 95s [259] 1.5813420 1.5813420 1.5813420 1.5813420 0.1978277 -10.9165932 95s [265] -10.9165932 -10.9165932 -10.9165932 -10.9165932 -10.9165932 1.5813420 95s [271] 2.9257679 2.9257679 -8.0465953 1.5813420 1.5813420 1.5813420 95s [277] -8.0465953 2.9257679 1.5813420 2.9257679 1.5813420 1.5813420 95s [283] 1.5813420 1.5813420 -8.0465953 2.9257679 1.5813420 0.1978277 95s [289] -10.9165932 1.5813420 1.5813420 -10.9165932 -8.0465953 1.5813420 95s [295] -10.9165932 -10.9165932 2.9257679 -10.9165932 1.5813420 2.9257679 95s [301] 1.5813420 1.5813420 2.9257679 1.5813420 1.5813420 -8.0465953 95s [307] 1.5813420 -8.0465953 0.1978277 -8.0465953 -8.0465953 -10.9165932 95s [313] 2.9257679 -10.9165932 1.5813420 -8.0465953 2.9257679 -10.9165932 95s [319] 2.9257679 0.1978277 1.5813420 -10.9165932 1.5813420 1.5813420 95s [325] -10.9165932 2.9257679 2.9257679 2.9257679 2.9257679 0.1978277 95s [331] -8.0465953 -10.9165932 1.5813420 -10.9165932 1.5813420 2.9257679 95s [337] 1.5813420 1.5813420 1.5813420 1.5813420 1.5813420 2.9257679 95s [343] 1.5813420 -8.0465953 2.9257679 2.9257679 -8.0465953 0.1978277 95s [349] -8.0465953 1.5813420 1.5813420 1.5813420 2.9257679 95s 95s $se.fit 95s [1] 0.3179632 0.3179632 0.4944930 0.5940988 0.4944930 0.4944930 0.5551694 95s [8] 0.5551694 0.4944930 0.5940988 0.3179632 0.3179632 0.5590023 0.3179632 95s [15] 0.3179632 0.3179632 0.3179632 0.3179632 0.5551694 0.3179632 0.3179632 95s [22] 0.5551694 0.4944930 0.4944930 0.5551694 0.5551694 0.5940988 0.3179632 95s [29] 0.5940988 0.5940988 0.4944930 0.5551694 0.5590023 0.3179632 0.5551694 95s [36] 0.4944930 0.4944930 0.3179632 0.4944930 0.5940988 0.3179632 0.3179632 95s [43] 0.3179632 0.5940988 0.3179632 0.3179632 0.5590023 0.3179632 0.4944930 95s [50] 0.4944930 0.3179632 0.5551694 0.3179632 0.3179632 0.5551694 0.3179632 95s [57] 0.5551694 0.4944930 0.3179632 0.5940988 0.3179632 0.4944930 0.3179632 95s [64] 0.4944930 0.4944930 0.3179632 0.3179632 0.5940988 0.3179632 0.5940988 95s [71] 0.3179632 0.5940988 0.3179632 0.3179632 0.5551694 0.4944930 0.5551694 95s [78] 0.4944930 0.3179632 0.3179632 0.3179632 0.3179632 0.4944930 0.5940988 95s [85] 0.3179632 0.3179632 0.3179632 0.5551694 0.5551694 0.5551694 0.5551694 95s [92] 0.5940988 0.3179632 0.3179632 0.5940988 0.3179632 0.3179632 0.5940988 95s [99] 0.3179632 0.5551694 0.3179632 0.5551694 0.5940988 0.5940988 0.5940988 95s [106] 0.3179632 0.4944930 0.3179632 0.5940988 0.5551694 0.4944930 0.5940988 95s [113] 0.3179632 0.5551694 0.3179632 0.5551694 0.4944930 0.3179632 0.5551694 95s [120] 0.3179632 0.5590023 0.4944930 0.3179632 0.3179632 0.5551694 0.3179632 95s [127] 0.5940988 0.4944930 0.3179632 0.4944930 0.3179632 0.5940988 0.3179632 95s [134] 0.3179632 0.3179632 0.3179632 0.3179632 0.4944930 0.4944930 0.5551694 95s [141] 0.5590023 0.3179632 0.5551694 0.3179632 0.4944930 0.3179632 0.5590023 95s [148] 0.3179632 0.5551694 0.5551694 0.5940988 0.4944930 0.5551694 0.5940988 95s [155] 0.4944930 0.5940988 0.5590023 0.5590023 0.3179632 0.5551694 0.3179632 95s [162] 0.3179632 0.5940988 0.5940988 0.3179632 0.3179632 0.3179632 0.3179632 95s [169] 0.5940988 0.5590023 0.5551694 0.4944930 0.3179632 0.5590023 0.3179632 95s [176] 0.4944930 0.4944930 0.3179632 0.3179632 0.3179632 0.3179632 0.3179632 95s [183] 0.5940988 0.4944930 0.5551694 0.3179632 0.3179632 0.3179632 0.5940988 95s [190] 0.4944930 0.3179632 0.4944930 0.5940988 0.4944930 0.3179632 0.3179632 95s [197] 0.3179632 0.5551694 0.5590023 0.5940988 0.3179632 0.5940988 0.3179632 95s [204] 0.5551694 0.3179632 0.4944930 0.3179632 0.4944930 0.3179632 0.5940988 95s [211] 0.5940988 0.3179632 0.4944930 0.4944930 0.5940988 0.5551694 0.4944930 95s [218] 0.3179632 0.3179632 0.5551694 0.4944930 0.3179632 0.3179632 0.5551694 95s [225] 0.4944930 0.5590023 0.3179632 0.5940988 0.3179632 0.5551694 0.3179632 95s [232] 0.3179632 0.4944930 0.5551694 0.3179632 0.3179632 0.4944930 0.5551694 95s [239] 0.4944930 0.4944930 0.3179632 0.4944930 0.5551694 0.5940988 0.3179632 95s [246] 0.4944930 0.3179632 0.3179632 0.4944930 0.5940988 0.5551694 0.5551694 95s [253] 0.5590023 0.5940988 0.3179632 0.5940988 0.4944930 0.5551694 0.3179632 95s [260] 0.3179632 0.3179632 0.3179632 0.5590023 0.5551694 0.5551694 0.5551694 95s [267] 0.5551694 0.5551694 0.5551694 0.3179632 0.4944930 0.4944930 0.5940988 95s [274] 0.3179632 0.3179632 0.3179632 0.5940988 0.4944930 0.3179632 0.4944930 95s [281] 0.3179632 0.3179632 0.3179632 0.3179632 0.5940988 0.4944930 0.3179632 95s [288] 0.5590023 0.5551694 0.3179632 0.3179632 0.5551694 0.5940988 0.3179632 95s [295] 0.5551694 0.5551694 0.4944930 0.5551694 0.3179632 0.4944930 0.3179632 95s [302] 0.3179632 0.4944930 0.3179632 0.3179632 0.5940988 0.3179632 0.5940988 95s [309] 0.5590023 0.5940988 0.5940988 0.5551694 0.4944930 0.5551694 0.3179632 95s [316] 0.5940988 0.4944930 0.5551694 0.4944930 0.5590023 0.3179632 0.5551694 95s [323] 0.3179632 0.3179632 0.5551694 0.4944930 0.4944930 0.4944930 0.4944930 95s [330] 0.5590023 0.5940988 0.5551694 0.3179632 0.5551694 0.3179632 0.4944930 95s [337] 0.3179632 0.3179632 0.3179632 0.3179632 0.3179632 0.4944930 0.3179632 95s [344] 0.5940988 0.4944930 0.4944930 0.5940988 0.5590023 0.5940988 0.3179632 95s [351] 0.3179632 0.3179632 0.4944930 95s 95s [1] 50.13645 95s [1] 2052.27 95s [1] 2052.27 95s Dose Response Model 95s 95s Model: sigEmax 95s Fit-type: normal 95s 95s Residuals: 95s Min 1Q Median 3Q Max 95s -13.6642 -2.5494 -0.0589 3.1494 10.8255 95s 95s Coefficients with approx. stand. error: 95s Estimate Std. Error 95s e0 -9.3604 8.43e-01 95s eMax 18.0312 4.04e+00 95s ed50 427.8168 1.83e+02 95s h 1.3276 3.36e-01 95s age -0.0117 8.11e-03 95s centergreen -0.7488 7.57e-01 95s centerred -0.8859 7.12e-01 95s centersilver -1.4084 7.52e-01 95s centeryellow -1.4438 7.33e-01 95s 95s Residual standard error: 4.36 95s Degrees of freedom: 344 95s 95s Formula: y ~ cbind(XX, sigEmax(x, 0, 1, ed50, h)) 95s 95s Parameters: 95s Estimate Std. Error t value Pr(>|t|) 95s ed50 427.813485 182.738231 2.341 0.0198 * 95s h 1.327626 0.335875 3.953 9.38e-05 *** 95s .lin.(Intercept) -9.360422 0.842795 -11.106 < 2e-16 *** 95s .lin.centergreen -0.748766 0.757412 -0.989 0.3236 95s .lin.centerred -0.885871 0.711909 -1.244 0.2142 95s .lin.centersilver -1.408359 0.752071 -1.873 0.0620 . 95s .lin.centeryellow -1.443811 0.733469 -1.968 0.0498 * 95s .lin.age -0.011703 0.008114 -1.442 0.1501 95s .lin7 18.031101 4.042408 4.460 1.11e-05 *** 95s --- 95s Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 95s 95s Residual standard error: 4.36 on 344 degrees of freedom 95s 95s Number of iterations to convergence: 4 95s Achieved convergence tolerance: 7.015e-06 95s 95s e0 eMax ed50 h 95s e0 0.710302651 -4.248050e-01 12.9547646 5.611113e-02 95s eMax -0.424805031 1.634158e+01 694.3472385 -1.241172e+00 95s ed50 12.954764634 6.943472e+02 33394.5386095 -4.820462e+01 95s h 0.056111134 -1.241172e+00 -48.2046174 1.128111e-01 95s age -0.003282055 -7.347999e-04 -0.0251683 3.613375e-05 95s centergreen -0.239527553 2.751352e-02 1.4126289 -4.650674e-03 95s centerred -0.290825609 -1.412230e-01 -9.3345325 5.133219e-03 95s centersilver -0.296694203 -2.684223e-01 -15.5401130 1.239080e-02 95s centeryellow -0.294618448 -1.827692e-01 -11.6914478 8.045886e-03 95s age centergreen centerred centersilver 95s e0 -3.282055e-03 -0.2395275534 -2.908256e-01 -2.966942e-01 95s eMax -7.347999e-04 0.0275135152 -1.412230e-01 -2.684223e-01 95s ed50 -2.516830e-02 1.4126288560 -9.334532e+00 -1.554011e+01 95s h 3.613375e-05 -0.0046506738 5.133219e-03 1.239080e-02 95s age 6.584109e-05 -0.0004705249 3.847994e-05 1.268608e-04 95s centergreen -4.705249e-04 0.5736725480 2.674552e-01 2.669211e-01 95s centerred 3.847994e-05 0.2674552437 5.068148e-01 2.741110e-01 95s centersilver 1.268608e-04 0.2669210775 2.741110e-01 5.656114e-01 95s centeryellow 3.360823e-05 0.2672881708 2.729000e-01 2.753064e-01 95s centeryellow 95s e0 -2.946184e-01 95s eMax -1.827692e-01 95s ed50 -1.169145e+01 95s h 8.045886e-03 95s age 3.360823e-05 95s centergreen 2.672882e-01 95s centerred 2.729000e-01 95s centersilver 2.753064e-01 95s centeryellow 5.379774e-01 95s ed50 h .lin.(Intercept) .lin.centergreen 95s ed50 3.339326e+04 -4.820368e+01 12.954858536 1.4125956498 95s h -4.820368e+01 1.128119e-01 0.056111300 -0.0046506961 95s .lin.(Intercept) 1.295486e+01 5.611130e-02 0.710302646 -0.2395275486 95s .lin.centergreen 1.412596e+00 -4.650696e-03 -0.239527549 0.5736725489 95s .lin.centerred -9.334399e+00 5.133264e-03 -0.290825609 0.2674552405 95s .lin.centersilver -1.553987e+01 1.239088e-02 -0.296694200 0.2669210724 95s .lin.centeryellow -1.169127e+01 8.045945e-03 -0.294618447 0.2672881668 95s .lin.age -2.516784e-02 3.613396e-05 -0.003282055 -0.0004705249 95s .lin7 6.943216e+02 -1.241157e+00 -0.424801861 0.0275129941 95s .lin.centerred .lin.centersilver .lin.centeryellow 95s ed50 -9.334399e+00 -1.553987e+01 -1.169127e+01 95s h 5.133264e-03 1.239088e-02 8.045945e-03 95s .lin.(Intercept) -2.908256e-01 -2.966942e-01 -2.946184e-01 95s .lin.centergreen 2.674552e-01 2.669211e-01 2.672882e-01 95s .lin.centerred 5.068148e-01 2.741110e-01 2.729000e-01 95s .lin.centersilver 2.741110e-01 5.656114e-01 2.753064e-01 95s .lin.centeryellow 2.729000e-01 2.753064e-01 5.379774e-01 95s .lin.age 3.847993e-05 1.268608e-04 3.360822e-05 95s .lin7 -1.412207e-01 -2.684181e-01 -1.827662e-01 95s .lin.age .lin7 95s ed50 -2.516784e-02 694.321579932 95s h 3.613396e-05 -1.241156974 95s .lin.(Intercept) -3.282055e-03 -0.424801861 95s .lin.centergreen -4.705249e-04 0.027512994 95s .lin.centerred 3.847993e-05 -0.141220710 95s .lin.centersilver 1.268608e-04 -0.268418091 95s .lin.centeryellow 3.360822e-05 -0.182766244 95s .lin.age 6.584109e-05 -0.000734791 95s .lin7 -7.347910e-04 16.341065046 95s $fit 95s [1] 0.000000 2.286007 95s 95s $se.fit 95s [1] 0.0000000 0.7638951 95s 95s $fit 95s [1] -11.353936 -9.067928 95s 95s $se.fit 95s [1] 0.7291152 0.7547668 95s 95s [1] 50.56495 95s [1] 336.0966 95s [1] 336.0966 95s Dose Response Model 95s 95s Model: logistic 95s Fit-type: normal 95s 95s Residuals: 95s Min 1Q Median 3Q Max 95s -6.606 -1.402 -0.298 1.561 5.618 95s 95s Coefficients with approx. stand. error: 95s Estimate Std. Error 95s e0 -8.93 1.09 95s eMax 7.45 1.19 95s ed50 288.28 49.89 95s delta 43.71 37.57 95s 95s Residual standard error: 2.32 95s Degrees of freedom: 69 95s 95s Formula: y ~ logistic(x, e0, emax, ed50, delta) 95s 95s Parameters: 95s Estimate Std. Error t value Pr(>|t|) 95s e0 -8.931 1.092 -8.179 9.42e-12 *** 95s emax 7.453 1.192 6.251 2.94e-08 *** 95s ed50 288.282 49.890 5.778 1.99e-07 *** 95s delta 43.709 37.566 1.164 0.249 95s --- 95s Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 95s 95s Residual standard error: 2.323 on 69 degrees of freedom 95s 95s Number of iterations to convergence: 5 95s Achieved convergence tolerance: 1.876e-07 95s 95s e0 eMax ed50 delta 95s e0 1.192360 -1.220565 45.77140 -33.34815 95s eMax -1.220565 1.421491 -43.96678 35.28563 95s ed50 45.771405 -43.966776 2488.99412 -1733.71529 95s delta -33.348146 35.285634 -1733.71529 1411.22519 95s e0 emax ed50 delta 95s e0 1.192360 -1.220566 45.77134 -33.34807 95s emax -1.220566 1.421491 -43.96671 35.28556 95s ed50 45.771344 -43.966710 2488.98697 -1733.70785 95s delta -33.348068 35.285556 -1733.70785 1411.21841 95s $fit 95s [1] 0.0000000 5.6020564 7.4419763 7.4430636 5.6020564 0.3578039 7.4430636 95s [8] 0.3578039 7.4130064 7.4419763 5.6020564 5.6020564 5.6020564 5.6020564 95s [15] 5.6020564 5.6020564 7.4130064 0.3578039 0.3578039 7.4419763 0.3578039 95s [22] 7.4430636 0.3578039 7.4419763 7.4430636 0.3578039 7.4419763 7.4419763 95s [29] 5.6020564 0.0000000 7.4419763 5.6020564 7.4130064 7.4130064 7.4430636 95s [36] 0.0000000 7.4419763 7.4430636 5.6020564 5.6020564 5.6020564 7.4419763 95s [43] 5.6020564 0.3578039 7.4130064 5.6020564 7.4419763 0.3578039 5.6020564 95s [50] 0.0000000 5.6020564 7.4130064 7.4430636 5.6020564 0.3578039 7.4419763 95s [57] 7.4130064 7.4430636 7.4419763 7.4430636 0.0000000 5.6020564 5.6020564 95s [64] 5.6020564 7.4419763 5.6020564 7.4419763 7.4130064 7.4419763 5.6020564 95s [71] 5.6020564 0.3578039 5.6020564 95s 95s $se.fit 95s [1] 0.000000 1.134891 1.131632 1.137062 1.134891 1.244804 1.137062 1.244804 95s [9] 1.051179 1.131632 1.134891 1.134891 1.134891 1.134891 1.134891 1.134891 95s [17] 1.051179 1.244804 1.244804 1.131632 1.244804 1.137062 1.244804 1.131632 95s [25] 1.137062 1.244804 1.131632 1.131632 1.134891 0.000000 1.131632 1.134891 95s [33] 1.051179 1.051179 1.137062 0.000000 1.131632 1.137062 1.134891 1.134891 95s [41] 1.134891 1.131632 1.134891 1.244804 1.051179 1.134891 1.131632 1.244804 95s [49] 1.134891 0.000000 1.134891 1.051179 1.137062 1.134891 1.244804 1.131632 95s [57] 1.051179 1.137062 1.131632 1.137062 0.000000 1.134891 1.134891 1.134891 95s [65] 1.131632 1.134891 1.131632 1.051179 1.131632 1.134891 1.134891 1.244804 95s [73] 1.134891 95s 95s $fit 95s [1] -8.920547 -3.318491 -1.478571 -1.477483 -3.318491 -8.562743 -1.477483 95s [8] -8.562743 -1.507541 -1.478571 -3.318491 -3.318491 -3.318491 -3.318491 95s [15] -3.318491 -3.318491 -1.507541 -8.562743 -8.562743 -1.478571 -8.562743 95s [22] -1.477483 -8.562743 -1.478571 -1.477483 -8.562743 -1.478571 -1.478571 95s [29] -3.318491 -8.920547 -1.478571 -3.318491 -1.507541 -1.507541 -1.477483 95s [36] -8.920547 -1.478571 -1.477483 -3.318491 -3.318491 -3.318491 -1.478571 95s [43] -3.318491 -8.562743 -1.507541 -3.318491 -1.478571 -8.562743 -3.318491 95s [50] -8.920547 -3.318491 -1.507541 -1.477483 -3.318491 -8.562743 -1.478571 95s [57] -1.507541 -1.477483 -1.478571 -1.477483 -8.920547 -3.318491 -3.318491 95s [64] -3.318491 -1.478571 -3.318491 -1.478571 -1.507541 -1.478571 -3.318491 95s [71] -3.318491 -8.562743 -3.318491 95s 95s $se.fit 95s [1] 1.0345960 0.4644528 0.4144011 0.4155112 0.4644528 0.6986843 0.4155112 95s [8] 0.6986843 0.4088615 0.4144011 0.4644528 0.4644528 0.4644528 0.4644528 95s [15] 0.4644528 0.4644528 0.4088615 0.6986843 0.6986843 0.4144011 0.6986843 95s [22] 0.4155112 0.6986843 0.4144011 0.4155112 0.6986843 0.4144011 0.4144011 95s [29] 0.4644528 1.0345960 0.4144011 0.4644528 0.4088615 0.4088615 0.4155112 95s [36] 1.0345960 0.4144011 0.4155112 0.4644528 0.4644528 0.4644528 0.4144011 95s [43] 0.4644528 0.6986843 0.4088615 0.4644528 0.4144011 0.6986843 0.4644528 95s [50] 1.0345960 0.4644528 0.4088615 0.4155112 0.4644528 0.6986843 0.4144011 95s [57] 0.4088615 0.4155112 0.4144011 0.4155112 1.0345960 0.4644528 0.4644528 95s [64] 0.4644528 0.4144011 0.4644528 0.4144011 0.4088615 0.4144011 0.4644528 95s [71] 0.4644528 0.6986843 0.4644528 95s 95s [1] 174.1673 95s [1] 345.1575 95s [1] 345.1575 95s Dose Response Model 95s 95s Model: logistic 95s Fit-type: normal 95s 95s Residuals: 95s Min 1Q Median 3Q Max 95s -6.924 -1.388 -0.179 1.618 5.265 95s 95s Coefficients with approx. stand. error: 95s Estimate Std. Error 95s e0 -8.98657 1.419 95s eMax 7.65181 1.269 95s ed50 286.51988 50.767 95s delta 43.51040 36.726 95s age -0.00402 0.011 95s centergreen -0.12880 0.873 95s centerred 0.10022 0.975 95s centersilver 0.60689 0.985 95s centeryellow 0.06974 0.968 95s 95s Residual standard error: 2.4 95s Degrees of freedom: 64 95s 95s Formula: y ~ cbind(XX, logistic(x, 0, 1, ed50, delta)) 95s 95s Parameters: 95s Estimate Std. Error t value Pr(>|t|) 95s ed50 286.519963 50.768013 5.644 4.08e-07 *** 95s delta 43.510064 36.726739 1.185 0.241 95s .lin.(Intercept) -8.986562 1.418992 -6.333 2.71e-08 *** 95s .lin.centergreen -0.128797 0.873355 -0.147 0.883 95s .lin.centerred 0.100221 0.975122 0.103 0.918 95s .lin.centersilver 0.606894 0.985016 0.616 0.540 95s .lin.centeryellow 0.069737 0.968243 0.072 0.943 95s .lin.age -0.004017 0.011024 -0.364 0.717 95s .lin7 7.651799 1.268713 6.031 8.96e-08 *** 95s --- 95s Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 95s 95s Residual standard error: 2.396 on 64 degrees of freedom 95s 95s Number of iterations to convergence: 4 95s Achieved convergence tolerance: 6.656e-06 95s 95s e0 eMax ed50 delta 95s e0 2.013542598 -1.386381624 4.801326e+01 -3.320465e+01 95s eMax -1.386381624 1.609637809 -4.594280e+01 3.537786e+01 95s ed50 48.013263925 -45.942796986 2.577339e+03 -1.719550e+03 95s delta -33.204646034 35.377861782 -1.719550e+03 1.348832e+03 95s age -0.006268645 0.001147196 1.238916e-02 -1.182615e-04 95s centergreen -0.334052153 -0.153718220 1.779756e+00 -1.607538e+00 95s centerred -0.399667176 -0.068891593 -2.561521e+00 7.131922e-01 95s centersilver -0.538856175 0.113916607 8.446386e-02 -1.524166e+00 95s centeryellow -0.463856043 -0.044371048 -3.153773e+00 1.284203e+00 95s age centergreen centerred centersilver 95s e0 -0.0062686454 -0.3340521534 -0.399667176 -0.5388561747 95s eMax 0.0011471962 -0.1537182198 -0.068891593 0.1139166068 95s ed50 0.0123891577 1.7797560819 -2.561520564 0.0844638637 95s delta -0.0001182615 -1.6075377838 0.713192228 -1.5241663474 95s age 0.0001215321 -0.0007558322 -0.001348561 -0.0006628626 95s centergreen -0.0007558322 0.7627491953 0.499187248 0.4609636575 95s centerred -0.0013485609 0.4991872483 0.950863865 0.4738663247 95s centersilver -0.0006628626 0.4609636575 0.473866325 0.9702565708 95s centeryellow -0.0003700776 0.4923423826 0.498378928 0.4677967285 95s centeryellow 95s e0 -0.4638560434 95s eMax -0.0443710477 95s ed50 -3.1537729812 95s delta 1.2842028644 95s age -0.0003700776 95s centergreen 0.4923423826 95s centerred 0.4983789279 95s centersilver 0.4677967285 95s centeryellow 0.9374951281 95s ed50 delta .lin.(Intercept) .lin.centergreen 95s ed50 2.577391e+03 -1.719586e+03 48.013675185 1.7797792085 95s delta -1.719586e+03 1.348853e+03 -33.204886930 -1.6075529969 95s .lin.(Intercept) 4.801368e+01 -3.320489e+01 2.013538892 -0.3340522689 95s .lin.centergreen 1.779779e+00 -1.607553e+00 -0.334052269 0.7627491915 95s .lin.centerred -2.561536e+00 7.132042e-01 -0.399667184 0.4991872439 95s .lin.centersilver 8.448334e-02 -1.524165e+00 -0.538856203 0.4609636569 95s .lin.centeryellow -3.153788e+00 1.284211e+00 -0.463855840 0.4923423903 95s .lin.age 1.238909e-02 -1.181868e-04 -0.006268647 -0.0007558323 95s .lin7 -4.594320e+01 3.537808e+01 -1.386377258 -0.1537180630 95s .lin.centerred .lin.centersilver .lin.centeryellow 95s ed50 -2.561536031 0.0844833421 -3.1537878657 95s delta 0.713204179 -1.5241654679 1.2842107129 95s .lin.(Intercept) -0.399667184 -0.5388562027 -0.4638558403 95s .lin.centergreen 0.499187244 0.4609636569 0.4923423903 95s .lin.centerred 0.950863862 0.4738663195 0.4983789308 95s .lin.centersilver 0.473866320 0.9702565794 0.4677967413 95s .lin.centeryellow 0.498378931 0.4677967413 0.9374951277 95s .lin.age -0.001348561 -0.0006628628 -0.0003700776 95s .lin7 -0.068891567 0.1139166792 -0.0443712829 95s .lin.age .lin7 95s ed50 0.0123890859 -45.943204762 95s delta -0.0001181868 35.378079613 95s .lin.(Intercept) -0.0062686471 -1.386377258 95s .lin.centergreen -0.0007558323 -0.153718063 95s .lin.centerred -0.0013485609 -0.068891567 95s .lin.centersilver -0.0006628628 0.113916679 95s .lin.centeryellow -0.0003700776 -0.044371283 95s .lin.age 0.0001215321 0.001147198 95s .lin7 0.0011471982 1.609632577 95s $fit 95s [1] 0.00000000 0.09322688 95s 95s $se.fit 95s [1] 0.0000000 0.4246053 95s 95s $fit 95s [1] -8.389208 -8.295981 95s 95s $se.fit 95s [1] 1.306647 1.060317 95s 95s [1] 46.37307 95s [1] -1501.193 95s [1] -1501.193 95s Dose Response Model 95s 95s Model: exponential 95s Fit-type: normal 95s 95s Residuals: 95s Min 1Q Median 3Q Max 95s -2.70e-01 -5.95e-02 7.18e-05 5.87e-02 2.44e-01 95s 95s Coefficients with approx. stand. error: 95s Estimate Std. Error 95s e0 -0.466 6.03e-03 95s e1 0.125 9.54e-02 95s delta 972.943 4.86e+02 95s 95s Residual standard error: 0.0841 95s Degrees of freedom: 710 95s 95s Formula: y ~ exponential(x, e0, e1, delta) 95s 95s Parameters: 95s Estimate Std. Error t value Pr(>|t|) 95s e0 -0.466094 0.006025 -77.359 <2e-16 *** 95s e1 0.124504 0.095374 1.305 0.1922 95s delta 972.943160 485.901974 2.002 0.0456 * 95s --- 95s Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 95s 95s Residual standard error: 0.08415 on 710 degrees of freedom 95s 95s Number of iterations to convergence: 0 95s Achieved convergence tolerance: 2.866e-08 95s 95s e0 e1 delta 95s e0 3.630154e-05 -0.0004207859 -2.060286 95s e1 -4.207859e-04 0.0090961445 46.252664 95s delta -2.060286e+00 46.2526644930 236100.519975 95s e0 e1 delta 95s e0 3.630155e-05 -0.0004207863 -2.060288 95s e1 -4.207863e-04 0.0090961522 46.252705 95s delta -2.060288e+00 46.2527045249 236100.728446 95s $fit 95s [1] 0.00000000 0.03271671 0.00000000 0.11169230 0.01605388 0.18278309 95s [7] 0.18278309 0.03271671 0.11169230 0.01605388 0.03271671 0.11169230 95s [13] 0.11169230 0.01605388 0.18278309 0.18278309 0.18278309 0.18278309 95s [19] 0.01605388 0.01605388 0.18278309 0.18278309 0.18278309 0.00000000 95s [25] 0.01605388 0.00000000 0.11169230 0.00000000 0.18278309 0.03271671 95s [31] 0.18278309 0.01605388 0.00000000 0.03271671 0.00000000 0.03271671 95s [37] 0.03271671 0.11169230 0.00000000 0.03271671 0.01605388 0.18278309 95s [43] 0.01605388 0.03271671 0.01605388 0.01605388 0.01605388 0.18278309 95s [49] 0.01605388 0.01605388 0.01605388 0.01605388 0.01605388 0.01605388 95s [55] 0.03271671 0.03271671 0.01605388 0.00000000 0.11169230 0.18278309 95s [61] 0.00000000 0.18278309 0.18278309 0.03271671 0.03271671 0.01605388 95s [67] 0.00000000 0.03271671 0.18278309 0.01605388 0.03271671 0.00000000 95s [73] 0.00000000 0.01605388 0.18278309 0.01605388 0.00000000 0.01605388 95s [79] 0.01605388 0.01605388 0.18278309 0.18278309 0.00000000 0.01605388 95s [85] 0.11169230 0.11169230 0.01605388 0.18278309 0.11169230 0.03271671 95s [91] 0.03271671 0.18278309 0.01605388 0.11169230 0.03271671 0.00000000 95s [97] 0.18278309 0.00000000 0.00000000 0.01605388 0.11169230 0.00000000 95s [103] 0.11169230 0.03271671 0.11169230 0.18278309 0.01605388 0.00000000 95s [109] 0.11169230 0.01605388 0.11169230 0.00000000 0.00000000 0.01605388 95s [115] 0.11169230 0.01605388 0.11169230 0.11169230 0.18278309 0.01605388 95s [121] 0.11169230 0.18278309 0.00000000 0.03271671 0.18278309 0.01605388 95s [127] 0.01605388 0.03271671 0.03271671 0.11169230 0.11169230 0.18278309 95s [133] 0.00000000 0.00000000 0.01605388 0.01605388 0.01605388 0.01605388 95s [139] 0.01605388 0.18278309 0.18278309 0.01605388 0.00000000 0.18278309 95s [145] 0.00000000 0.01605388 0.18278309 0.03271671 0.18278309 0.01605388 95s [151] 0.00000000 0.03271671 0.01605388 0.01605388 0.01605388 0.03271671 95s [157] 0.01605388 0.01605388 0.00000000 0.11169230 0.00000000 0.00000000 95s [163] 0.01605388 0.03271671 0.03271671 0.00000000 0.11169230 0.18278309 95s [169] 0.18278309 0.01605388 0.03271671 0.03271671 0.11169230 0.01605388 95s [175] 0.01605388 0.03271671 0.03271671 0.00000000 0.01605388 0.01605388 95s [181] 0.11169230 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0.007313632 0.003835233 0.006025076 95s [109] 0.006884091 0.003835233 0.006884091 0.006025076 0.006025076 0.003835233 95s [115] 0.006884091 0.003835233 0.006884091 0.006884091 0.007313632 0.003835233 95s [121] 0.006884091 0.007313632 0.006025076 0.004212735 0.007313632 0.003835233 95s [127] 0.003835233 0.004212735 0.004212735 0.006884091 0.006884091 0.007313632 95s [133] 0.006025076 0.006025076 0.003835233 0.003835233 0.003835233 0.003835233 95s [139] 0.003835233 0.007313632 0.007313632 0.003835233 0.006025076 0.007313632 95s [145] 0.006025076 0.003835233 0.007313632 0.004212735 0.007313632 0.003835233 95s [151] 0.006025076 0.004212735 0.003835233 0.003835233 0.003835233 0.004212735 95s [157] 0.003835233 0.003835233 0.006025076 0.006884091 0.006025076 0.006025076 95s [163] 0.003835233 0.004212735 0.004212735 0.006025076 0.006884091 0.007313632 95s [169] 0.007313632 0.003835233 0.004212735 0.004212735 0.006884091 0.003835233 95s [175] 0.003835233 0.004212735 0.004212735 0.006025076 0.003835233 0.003835233 95s [181] 0.006884091 0.003835233 0.004212735 0.007313632 0.006884091 0.003835233 95s [187] 0.006884091 0.004212735 0.003835233 0.004212735 0.006025076 0.007313632 95s [193] 0.004212735 0.004212735 0.003835233 0.003835233 0.003835233 0.006884091 95s [199] 0.003835233 0.006025076 0.006884091 0.006884091 0.003835233 0.004212735 95s [205] 0.006025076 0.003835233 0.006025076 0.006025076 0.003835233 0.003835233 95s [211] 0.003835233 0.004212735 0.003835233 0.004212735 0.003835233 0.007313632 95s [217] 0.003835233 0.006884091 0.003835233 0.007313632 0.006884091 0.003835233 95s [223] 0.006884091 0.007313632 0.004212735 0.007313632 0.004212735 0.006884091 95s [229] 0.006884091 0.006025076 0.003835233 0.003835233 0.006884091 0.006025076 95s [235] 0.007313632 0.004212735 0.003835233 0.006884091 0.007313632 0.007313632 95s [241] 0.003835233 0.004212735 0.006025076 0.004212735 0.007313632 0.003835233 95s [247] 0.003835233 0.004212735 0.003835233 0.006884091 0.004212735 0.004212735 95s [253] 0.006884091 0.006025076 0.006025076 0.006025076 0.003835233 0.006884091 95s [259] 0.007313632 0.003835233 0.007313632 0.003835233 0.007313632 0.004212735 95s [265] 0.003835233 0.004212735 0.003835233 0.007313632 0.007313632 0.004212735 95s [271] 0.003835233 0.007313632 0.006884091 0.003835233 0.007313632 0.003835233 95s [277] 0.003835233 0.007313632 0.006884091 0.003835233 0.007313632 0.004212735 95s [283] 0.007313632 0.003835233 0.006025076 0.003835233 0.003835233 0.003835233 95s [289] 0.006884091 0.004212735 0.004212735 0.003835233 0.004212735 0.003835233 95s [295] 0.004212735 0.006025076 0.006025076 0.003835233 0.006025076 0.003835233 95s [301] 0.006884091 0.006884091 0.007313632 0.006884091 0.003835233 0.003835233 95s [307] 0.003835233 0.004212735 0.004212735 0.004212735 0.003835233 0.007313632 95s [313] 0.004212735 0.004212735 0.006884091 0.003835233 0.004212735 0.006884091 95s [319] 0.004212735 0.006884091 0.004212735 0.003835233 0.003835233 0.003835233 95s [325] 0.007313632 0.006884091 0.003835233 0.004212735 0.007313632 0.003835233 95s [331] 0.006884091 0.004212735 0.003835233 0.004212735 0.004212735 0.003835233 95s [337] 0.003835233 0.006884091 0.003835233 0.004212735 0.003835233 0.003835233 95s [343] 0.006025076 0.003835233 0.004212735 0.003835233 0.006884091 0.007313632 95s [349] 0.003835233 0.003835233 0.003835233 0.007313632 0.006884091 0.004212735 95s [355] 0.007313632 0.003835233 0.006884091 0.004212735 0.004212735 0.003835233 95s [361] 0.003835233 0.003835233 0.003835233 0.006025076 0.004212735 0.007313632 95s [367] 0.004212735 0.007313632 0.007313632 0.003835233 0.003835233 0.006884091 95s [373] 0.003835233 0.006884091 0.003835233 0.007313632 0.007313632 0.003835233 95s [379] 0.007313632 0.007313632 0.006884091 0.006884091 0.007313632 0.004212735 95s [385] 0.007313632 0.004212735 0.007313632 0.003835233 0.006884091 0.006025076 95s [391] 0.003835233 0.006025076 0.006025076 0.003835233 0.003835233 0.004212735 95s [397] 0.004212735 0.004212735 0.006025076 0.006025076 0.003835233 0.006025076 95s [403] 0.006884091 0.004212735 0.004212735 0.006025076 0.004212735 0.003835233 95s [409] 0.003835233 0.007313632 0.004212735 0.003835233 0.004212735 0.006884091 95s [415] 0.003835233 0.006884091 0.007313632 0.006884091 0.003835233 0.004212735 95s [421] 0.003835233 0.003835233 0.007313632 0.004212735 0.006884091 0.003835233 95s [427] 0.004212735 0.006025076 0.007313632 0.003835233 0.006884091 0.003835233 95s [433] 0.003835233 0.003835233 0.006025076 0.003835233 0.006884091 0.006025076 95s [439] 0.004212735 0.004212735 0.003835233 0.003835233 0.003835233 0.004212735 95s [445] 0.006025076 0.006025076 0.003835233 0.003835233 0.006025076 0.004212735 95s [451] 0.007313632 0.003835233 0.006884091 0.006025076 0.003835233 0.006025076 95s [457] 0.003835233 0.006025076 0.007313632 0.003835233 0.003835233 0.006884091 95s [463] 0.003835233 0.004212735 0.007313632 0.007313632 0.006884091 0.007313632 95s [469] 0.003835233 0.003835233 0.006025076 0.003835233 0.003835233 0.004212735 95s [475] 0.007313632 0.004212735 0.003835233 0.007313632 0.004212735 0.006884091 95s [481] 0.006025076 0.003835233 0.007313632 0.004212735 0.003835233 0.004212735 95s [487] 0.007313632 0.006884091 0.007313632 0.003835233 0.006884091 0.007313632 95s [493] 0.006884091 0.007313632 0.004212735 0.003835233 0.007313632 0.004212735 95s [499] 0.004212735 0.003835233 0.007313632 0.006884091 0.007313632 0.007313632 95s [505] 0.003835233 0.006025076 0.003835233 0.007313632 0.007313632 0.003835233 95s [511] 0.004212735 0.003835233 0.007313632 0.003835233 0.003835233 0.004212735 95s [517] 0.003835233 0.003835233 0.004212735 0.006025076 0.004212735 0.004212735 95s [523] 0.007313632 0.004212735 0.004212735 0.004212735 0.004212735 0.006025076 95s [529] 0.003835233 0.007313632 0.004212735 0.006884091 0.007313632 0.003835233 95s [535] 0.003835233 0.003835233 0.003835233 0.006884091 0.007313632 0.006025076 95s [541] 0.004212735 0.006884091 0.004212735 0.007313632 0.004212735 0.003835233 95s [547] 0.004212735 0.006025076 0.006025076 0.007313632 0.004212735 0.006884091 95s [553] 0.006884091 0.003835233 0.006025076 0.004212735 0.006025076 0.003835233 95s [559] 0.003835233 0.003835233 0.007313632 0.007313632 0.007313632 0.004212735 95s [565] 0.004212735 0.003835233 0.006884091 0.006884091 0.004212735 0.003835233 95s [571] 0.006884091 0.006025076 0.006025076 0.003835233 0.006025076 0.003835233 95s [577] 0.004212735 0.004212735 0.006025076 0.003835233 0.003835233 0.006884091 95s [583] 0.004212735 0.007313632 0.003835233 0.006884091 0.007313632 0.003835233 95s [589] 0.003835233 0.003835233 0.007313632 0.003835233 0.007313632 0.003835233 95s [595] 0.007313632 0.007313632 0.006884091 0.004212735 0.004212735 0.003835233 95s [601] 0.003835233 0.003835233 0.007313632 0.004212735 0.004212735 0.003835233 95s [607] 0.003835233 0.007313632 0.007313632 0.006884091 0.004212735 0.007313632 95s [613] 0.007313632 0.003835233 0.003835233 0.006025076 0.007313632 0.003835233 95s [619] 0.006884091 0.003835233 0.006884091 0.006025076 0.003835233 0.003835233 95s [625] 0.007313632 0.003835233 0.004212735 0.004212735 0.006025076 0.006025076 95s [631] 0.006025076 0.006025076 0.006025076 0.003835233 0.007313632 0.004212735 95s [637] 0.006025076 0.003835233 0.006884091 0.007313632 0.003835233 0.006884091 95s [643] 0.003835233 0.006025076 0.003835233 0.004212735 0.004212735 0.003835233 95s [649] 0.006025076 0.003835233 0.006884091 0.006884091 0.007313632 0.007313632 95s [655] 0.006884091 0.003835233 0.004212735 0.004212735 0.003835233 0.003835233 95s [661] 0.006025076 0.003835233 0.004212735 0.006884091 0.003835233 0.003835233 95s [667] 0.003835233 0.003835233 0.003835233 0.003835233 0.006025076 0.003835233 95s [673] 0.004212735 0.007313632 0.003835233 0.003835233 0.007313632 0.006025076 95s [679] 0.004212735 0.003835233 0.007313632 0.004212735 0.006884091 0.003835233 95s [685] 0.007313632 0.007313632 0.006884091 0.004212735 0.006025076 0.004212735 95s [691] 0.003835233 0.003835233 0.003835233 0.006884091 0.007313632 0.003835233 95s [697] 0.003835233 0.003835233 0.003835233 0.003835233 0.003835233 0.003835233 95s [703] 0.006884091 0.006884091 0.003835233 0.003835233 0.003835233 0.003835233 95s [709] 0.004212735 0.006884091 0.003835233 0.007313632 0.003835233 95s 95s [1] 573.604 95s [1] -1502.21 95s [1] -1502.21 95s Dose Response Model 95s 95s Model: exponential 95s Fit-type: normal 95s 95s Residuals: 95s Min 1Q Median 3Q Max 95s -2.72e-01 -5.96e-02 -5.44e-06 5.59e-02 2.43e-01 95s 95s Coefficients with approx. stand. error: 95s Estimate Std. Error 95s e0 -4.57e-01 1.03e-02 95s e1 1.24e-01 9.45e-02 95s delta 9.69e+02 4.79e+02 95s age -2.46e-04 1.09e-04 95s centergreen -2.26e-03 9.93e-03 95s centerred 7.10e-03 9.88e-03 95s centersilver 1.68e-02 1.02e-02 95s centeryellow -4.45e-03 1.01e-02 95s 95s Residual standard error: 0.0838 95s Degrees of freedom: 705 95s 95s Formula: y ~ cbind(XX, exponential(x, 0, 1, delta)) 95s 95s Parameters: 95s Estimate Std. Error t value Pr(>|t|) 95s delta 9.692e+02 4.795e+02 2.021 0.0436 * 95s .lin.(Intercept) -4.574e-01 1.035e-02 -44.200 <2e-16 *** 95s .lin.centergreen -2.256e-03 9.934e-03 -0.227 0.8204 95s .lin.centerred 7.104e-03 9.875e-03 0.719 0.4721 95s .lin.centersilver 1.682e-02 1.018e-02 1.652 0.0989 . 95s .lin.centeryellow -4.446e-03 1.005e-02 -0.442 0.6584 95s .lin.age -2.463e-04 1.090e-04 -2.259 0.0242 * 95s .lin7 1.244e-01 9.455e-02 1.316 0.1886 95s --- 95s Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 95s 95s Residual standard error: 0.0838 on 705 degrees of freedom 95s 95s Number of iterations to convergence: 7 95s Achieved convergence tolerance: 8.761e-06 95s 95s e0 e1 delta age 95s e0 1.070950e-04 -3.644584e-04 -1.760351e+00 -6.235809e-07 95s e1 -3.644584e-04 8.939486e-03 4.524835e+01 -1.892276e-07 95s delta -1.760351e+00 4.524835e+01 2.299191e+05 -9.417516e-04 95s age -6.235809e-07 -1.892276e-07 -9.417516e-04 1.188604e-08 95s centergreen -4.990019e-05 -7.223389e-05 -3.668153e-01 4.308966e-08 95s centerred -5.090480e-05 -5.257813e-05 -2.765207e-01 2.992730e-08 95s centersilver -5.269569e-05 -5.104405e-05 -2.725147e-01 5.557593e-08 95s centeryellow -5.416568e-05 -3.395837e-05 -1.820279e-01 7.695026e-08 95s centergreen centerred centersilver centeryellow 95s e0 -4.990019e-05 -5.090480e-05 -5.269569e-05 -5.416568e-05 95s e1 -7.223389e-05 -5.257813e-05 -5.104405e-05 -3.395837e-05 95s delta -3.668153e-01 -2.765207e-01 -2.725147e-01 -1.820279e-01 95s age 4.308966e-08 2.992730e-08 5.557593e-08 7.695026e-08 95s centergreen 9.869293e-05 5.105736e-05 5.114013e-05 5.107251e-05 95s centerred 5.105736e-05 9.752101e-05 5.111632e-05 5.102188e-05 95s centersilver 5.114013e-05 5.111632e-05 1.036881e-04 5.122455e-05 95s centeryellow 5.107251e-05 5.102188e-05 5.122455e-05 1.010538e-04 95s delta .lin.(Intercept) .lin.centergreen 95s delta 2.299104e+05 -1.760315e+00 -3.668084e-01 95s .lin.(Intercept) -1.760315e+00 1.070949e-04 -4.990020e-05 95s .lin.centergreen -3.668084e-01 -4.990020e-05 9.869293e-05 95s .lin.centerred -2.765154e-01 -5.090480e-05 5.105736e-05 95s .lin.centersilver -2.725097e-01 -5.269570e-05 5.114013e-05 95s .lin.centeryellow -1.820244e-01 -5.416569e-05 5.107251e-05 95s .lin.age -9.417341e-04 -6.235810e-07 4.308966e-08 95s .lin7 4.524658e+01 -3.644504e-04 -7.223243e-05 95s .lin.centerred .lin.centersilver .lin.centeryellow 95s delta -2.765154e-01 -2.725097e-01 -1.820244e-01 95s .lin.(Intercept) -5.090480e-05 -5.269570e-05 -5.416569e-05 95s .lin.centergreen 5.105736e-05 5.114013e-05 5.107251e-05 95s .lin.centerred 9.752101e-05 5.111632e-05 5.102188e-05 95s .lin.centersilver 5.111632e-05 1.036881e-04 5.122455e-05 95s .lin.centeryellow 5.102188e-05 5.122455e-05 1.010538e-04 95s .lin.age 2.992730e-08 5.557593e-08 7.695026e-08 95s .lin7 -5.257703e-05 -5.104303e-05 -3.395768e-05 95s .lin.age .lin7 95s delta -9.417341e-04 4.524658e+01 95s .lin.(Intercept) -6.235810e-07 -3.644504e-04 95s .lin.centergreen 4.308966e-08 -7.223243e-05 95s .lin.centerred 2.992730e-08 -5.257703e-05 95s .lin.centersilver 5.557593e-08 -5.104303e-05 95s .lin.centeryellow 7.695026e-08 -3.395768e-05 95s .lin.age 1.188604e-08 -1.892238e-07 95s .lin7 -1.892238e-07 8.939124e-03 95s $fit 95s [1] 0.00000000 0.01352276 95s 95s $se.fit 95s [1] 0.000000000 0.003277925 95s 95s $fit 95s [1] -0.4697265 -0.4562037 95s 95s $se.fit 95s [1] 0.008628557 0.007549824 95s 95s [1] 571.7033 95s [1] 4189.744 95s [1] 4189.744 95s Dose Response Model 95s 95s Model: linear 95s Fit-type: normal 95s 95s Residuals: 95s Min 1Q Median 3Q Max 95s -20.3923 -4.1973 -0.0226 3.8448 25.3694 95s 95s Coefficients with approx. stand. error: 95s Estimate Std. Error 95s e0 -11.2122 0.393654 95s delta 0.0136 0.000531 95s 95s Residual standard error: 6.43 95s Degrees of freedom: 636 95s 95s Call: 95s lm(formula = y ~ x, data = datset) 95s 95s Residuals: 95s Min 1Q Median 3Q Max 95s -25.3694 -3.8448 0.0226 4.1973 20.3923 95s 95s Coefficients: 95s Estimate Std. Error t value Pr(>|t|) 95s (Intercept) -1.121e+01 3.937e-01 -28.48 <2e-16 *** 95s x 1.358e-02 5.313e-04 25.57 <2e-16 *** 95s --- 95s Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 95s 95s Residual standard error: 6.433 on 636 degrees of freedom 95s Multiple R-squared: 0.5069, Adjusted R-squared: 0.5061 95s F-statistic: 653.7 on 1 and 636 DF, p-value: < 2.2e-16 95s 95s e0 delta 95s e0 0.1549638101 -1.594693e-04 95s delta -0.0001594693 2.822434e-07 95s (Intercept) x 95s (Intercept) 0.1549638101 -1.594693e-04 95s x -0.0001594693 2.822434e-07 95s $fit 95s [1] 3.382287 6.560821 12.605469 12.605469 17.251020 0.000000 0.000000 95s [8] 6.560821 17.251020 3.382287 15.892672 3.382287 0.000000 9.671438 95s [15] 15.892672 17.251020 12.605469 17.251020 3.382287 17.251020 17.251020 95s [22] 9.671438 3.382287 12.605469 0.000000 12.605469 3.382287 6.560821 95s [29] 0.000000 17.251020 0.000000 9.671438 12.605469 3.382287 3.382287 95s [36] 0.000000 0.000000 12.605469 0.000000 12.605469 0.000000 15.892672 95s [43] 12.605469 15.892672 3.382287 17.251020 17.251020 6.560821 3.382287 95s [50] 0.000000 9.671438 17.251020 15.892672 0.000000 3.382287 17.251020 95s [57] 6.560821 17.251020 0.000000 3.382287 12.605469 12.605469 0.000000 95s [64] 0.000000 15.892672 15.892672 0.000000 12.605469 15.892672 3.382287 95s [71] 15.892672 6.560821 3.382287 17.251020 12.605469 0.000000 12.605469 95s [78] 12.605469 3.382287 0.000000 0.000000 0.000000 3.382287 3.382287 95s [85] 3.382287 6.560821 3.382287 0.000000 3.382287 17.251020 6.560821 95s [92] 3.382287 17.251020 9.671438 3.382287 0.000000 3.382287 3.382287 95s [99] 12.605469 0.000000 3.382287 3.382287 12.605469 0.000000 0.000000 95s [106] 17.251020 0.000000 6.560821 15.892672 17.251020 3.382287 17.251020 95s [113] 3.382287 0.000000 0.000000 3.382287 6.560821 0.000000 6.560821 95s [120] 3.382287 0.000000 0.000000 6.560821 15.892672 12.605469 12.605469 95s [127] 0.000000 17.251020 0.000000 17.251020 3.382287 0.000000 12.605469 95s [134] 17.251020 0.000000 3.382287 0.000000 6.560821 6.560821 6.560821 95s [141] 3.382287 17.251020 0.000000 0.000000 3.382287 0.000000 15.892672 95s [148] 17.251020 3.382287 15.892672 0.000000 17.251020 6.560821 3.382287 95s [155] 12.605469 6.560821 6.560821 3.382287 3.382287 0.000000 3.382287 95s [162] 0.000000 3.382287 12.605469 3.382287 0.000000 17.251020 0.000000 95s [169] 0.000000 3.382287 17.251020 3.382287 17.251020 15.892672 6.560821 95s [176] 12.605469 3.382287 0.000000 12.605469 0.000000 12.605469 17.251020 95s [183] 12.605469 0.000000 0.000000 12.605469 3.382287 12.605469 17.251020 95s [190] 3.382287 3.382287 17.251020 3.382287 6.560821 3.382287 17.251020 95s [197] 17.251020 0.000000 12.605469 0.000000 12.605469 3.382287 6.560821 95s [204] 12.605469 12.605469 3.382287 3.382287 12.605469 17.251020 12.605469 95s [211] 3.382287 3.382287 17.251020 0.000000 6.560821 3.382287 3.382287 95s [218] 0.000000 6.560821 0.000000 6.560821 6.560821 3.382287 0.000000 95s [225] 3.382287 3.382287 17.251020 3.382287 0.000000 17.251020 3.382287 95s [232] 6.560821 17.251020 0.000000 0.000000 3.382287 3.382287 12.605469 95s [239] 6.560821 12.605469 3.382287 12.605469 17.251020 6.560821 17.251020 95s [246] 17.251020 15.892672 0.000000 3.382287 3.382287 3.382287 0.000000 95s [253] 12.605469 15.892672 6.560821 3.382287 3.382287 0.000000 0.000000 95s [260] 12.605469 6.560821 3.382287 3.382287 12.605469 17.251020 0.000000 95s [267] 6.560821 15.892672 3.382287 15.892672 3.382287 12.605469 0.000000 95s [274] 17.251020 15.892672 6.560821 3.382287 12.605469 0.000000 3.382287 95s [281] 3.382287 12.605469 3.382287 0.000000 17.251020 15.892672 17.251020 95s [288] 3.382287 17.251020 3.382287 3.382287 3.382287 15.892672 0.000000 95s [295] 0.000000 17.251020 17.251020 12.605469 0.000000 12.605469 17.251020 95s [302] 15.892672 15.892672 0.000000 3.382287 12.605469 12.605469 15.892672 95s [309] 6.560821 15.892672 12.605469 12.605469 17.251020 0.000000 17.251020 95s [316] 3.382287 17.251020 3.382287 12.605469 0.000000 6.560821 3.382287 95s [323] 0.000000 15.892672 17.251020 17.251020 17.251020 3.382287 6.560821 95s [330] 0.000000 0.000000 12.605469 12.605469 12.605469 0.000000 12.605469 95s [337] 0.000000 15.892672 6.560821 17.251020 12.605469 12.605469 6.560821 95s [344] 0.000000 0.000000 17.251020 0.000000 0.000000 12.605469 0.000000 95s [351] 3.382287 3.382287 6.560821 17.251020 9.671438 0.000000 9.671438 95s [358] 9.671438 12.605469 3.382287 12.605469 3.382287 17.251020 0.000000 95s [365] 12.605469 0.000000 3.382287 0.000000 3.382287 6.560821 0.000000 95s [372] 6.560821 6.560821 17.251020 15.892672 0.000000 17.251020 0.000000 95s [379] 3.382287 17.251020 3.382287 12.605469 3.382287 3.382287 12.605469 95s [386] 3.382287 3.382287 0.000000 15.892672 0.000000 12.605469 0.000000 95s [393] 15.892672 6.560821 15.892672 15.892672 6.560821 6.560821 3.382287 95s [400] 3.382287 17.251020 17.251020 6.560821 12.605469 9.671438 15.892672 95s [407] 17.251020 6.560821 3.382287 0.000000 6.560821 6.560821 15.892672 95s [414] 3.382287 0.000000 0.000000 0.000000 0.000000 3.382287 3.382287 95s [421] 0.000000 3.382287 3.382287 12.605469 17.251020 17.251020 17.251020 95s [428] 0.000000 15.892672 17.251020 17.251020 0.000000 0.000000 17.251020 95s [435] 12.605469 6.560821 0.000000 0.000000 3.382287 0.000000 15.892672 95s [442] 12.605469 17.251020 3.382287 12.605469 0.000000 17.251020 0.000000 95s [449] 6.560821 12.605469 6.560821 12.605469 15.892672 12.605469 12.605469 95s [456] 0.000000 0.000000 3.382287 0.000000 3.382287 0.000000 0.000000 95s [463] 0.000000 17.251020 6.560821 17.251020 12.605469 12.605469 3.382287 95s [470] 17.251020 0.000000 3.382287 0.000000 6.560821 0.000000 0.000000 95s [477] 3.382287 15.892672 3.382287 12.605469 0.000000 3.382287 12.605469 95s [484] 6.560821 17.251020 9.671438 15.892672 17.251020 15.892672 0.000000 95s [491] 0.000000 3.382287 3.382287 17.251020 0.000000 6.560821 12.605469 95s [498] 12.605469 12.605469 3.382287 3.382287 3.382287 15.892672 0.000000 95s [505] 6.560821 3.382287 17.251020 3.382287 12.605469 12.605469 15.892672 95s [512] 0.000000 12.605469 17.251020 6.560821 0.000000 3.382287 0.000000 95s [519] 15.892672 0.000000 12.605469 12.605469 0.000000 17.251020 0.000000 95s [526] 9.671438 0.000000 3.382287 15.892672 3.382287 3.382287 3.382287 95s [533] 17.251020 15.892672 0.000000 0.000000 0.000000 15.892672 6.560821 95s [540] 17.251020 17.251020 6.560821 0.000000 0.000000 3.382287 12.605469 95s [547] 12.605469 0.000000 3.382287 15.892672 0.000000 0.000000 3.382287 95s [554] 0.000000 0.000000 0.000000 17.251020 17.251020 17.251020 12.605469 95s [561] 0.000000 15.892672 0.000000 3.382287 3.382287 12.605469 6.560821 95s [568] 12.605469 3.382287 3.382287 0.000000 17.251020 6.560821 15.892672 95s [575] 0.000000 9.671438 3.382287 3.382287 0.000000 12.605469 3.382287 95s [582] 12.605469 3.382287 0.000000 6.560821 0.000000 3.382287 17.251020 95s [589] 3.382287 12.605469 12.605469 17.251020 3.382287 9.671438 0.000000 95s [596] 17.251020 0.000000 6.560821 9.671438 9.671438 0.000000 0.000000 95s [603] 0.000000 12.605469 17.251020 12.605469 12.605469 6.560821 6.560821 95s [610] 15.892672 3.382287 6.560821 6.560821 9.671438 17.251020 17.251020 95s [617] 0.000000 3.382287 12.605469 15.892672 3.382287 0.000000 17.251020 95s [624] 12.605469 6.560821 17.251020 17.251020 0.000000 6.560821 15.892672 95s [631] 6.560821 6.560821 0.000000 15.892672 17.251020 0.000000 3.382287 95s [638] 17.251020 95s 95s $se.fit 95s [1] 0.1322852 0.2566014 0.4930147 0.4930147 0.6747076 0.0000000 0.0000000 95s [8] 0.2566014 0.6747076 0.1322852 0.6215810 0.1322852 0.0000000 0.3782613 95s [15] 0.6215810 0.6747076 0.4930147 0.6747076 0.1322852 0.6747076 0.6747076 95s [22] 0.3782613 0.1322852 0.4930147 0.0000000 0.4930147 0.1322852 0.2566014 95s [29] 0.0000000 0.6747076 0.0000000 0.3782613 0.4930147 0.1322852 0.1322852 95s [36] 0.0000000 0.0000000 0.4930147 0.0000000 0.4930147 0.0000000 0.6215810 95s [43] 0.4930147 0.6215810 0.1322852 0.6747076 0.6747076 0.2566014 0.1322852 95s [50] 0.0000000 0.3782613 0.6747076 0.6215810 0.0000000 0.1322852 0.6747076 95s [57] 0.2566014 0.6747076 0.0000000 0.1322852 0.4930147 0.4930147 0.0000000 95s [64] 0.0000000 0.6215810 0.6215810 0.0000000 0.4930147 0.6215810 0.1322852 95s [71] 0.6215810 0.2566014 0.1322852 0.6747076 0.4930147 0.0000000 0.4930147 95s [78] 0.4930147 0.1322852 0.0000000 0.0000000 0.0000000 0.1322852 0.1322852 95s [85] 0.1322852 0.2566014 0.1322852 0.0000000 0.1322852 0.6747076 0.2566014 95s [92] 0.1322852 0.6747076 0.3782613 0.1322852 0.0000000 0.1322852 0.1322852 95s [99] 0.4930147 0.0000000 0.1322852 0.1322852 0.4930147 0.0000000 0.0000000 95s [106] 0.6747076 0.0000000 0.2566014 0.6215810 0.6747076 0.1322852 0.6747076 95s [113] 0.1322852 0.0000000 0.0000000 0.1322852 0.2566014 0.0000000 0.2566014 95s [120] 0.1322852 0.0000000 0.0000000 0.2566014 0.6215810 0.4930147 0.4930147 95s [127] 0.0000000 0.6747076 0.0000000 0.6747076 0.1322852 0.0000000 0.4930147 95s [134] 0.6747076 0.0000000 0.1322852 0.0000000 0.2566014 0.2566014 0.2566014 95s [141] 0.1322852 0.6747076 0.0000000 0.0000000 0.1322852 0.0000000 0.6215810 95s [148] 0.6747076 0.1322852 0.6215810 0.0000000 0.6747076 0.2566014 0.1322852 95s [155] 0.4930147 0.2566014 0.2566014 0.1322852 0.1322852 0.0000000 0.1322852 95s [162] 0.0000000 0.1322852 0.4930147 0.1322852 0.0000000 0.6747076 0.0000000 95s [169] 0.0000000 0.1322852 0.6747076 0.1322852 0.6747076 0.6215810 0.2566014 95s [176] 0.4930147 0.1322852 0.0000000 0.4930147 0.0000000 0.4930147 0.6747076 95s [183] 0.4930147 0.0000000 0.0000000 0.4930147 0.1322852 0.4930147 0.6747076 95s [190] 0.1322852 0.1322852 0.6747076 0.1322852 0.2566014 0.1322852 0.6747076 95s [197] 0.6747076 0.0000000 0.4930147 0.0000000 0.4930147 0.1322852 0.2566014 95s [204] 0.4930147 0.4930147 0.1322852 0.1322852 0.4930147 0.6747076 0.4930147 95s [211] 0.1322852 0.1322852 0.6747076 0.0000000 0.2566014 0.1322852 0.1322852 95s [218] 0.0000000 0.2566014 0.0000000 0.2566014 0.2566014 0.1322852 0.0000000 95s [225] 0.1322852 0.1322852 0.6747076 0.1322852 0.0000000 0.6747076 0.1322852 95s [232] 0.2566014 0.6747076 0.0000000 0.0000000 0.1322852 0.1322852 0.4930147 95s [239] 0.2566014 0.4930147 0.1322852 0.4930147 0.6747076 0.2566014 0.6747076 95s [246] 0.6747076 0.6215810 0.0000000 0.1322852 0.1322852 0.1322852 0.0000000 95s [253] 0.4930147 0.6215810 0.2566014 0.1322852 0.1322852 0.0000000 0.0000000 95s [260] 0.4930147 0.2566014 0.1322852 0.1322852 0.4930147 0.6747076 0.0000000 95s [267] 0.2566014 0.6215810 0.1322852 0.6215810 0.1322852 0.4930147 0.0000000 95s [274] 0.6747076 0.6215810 0.2566014 0.1322852 0.4930147 0.0000000 0.1322852 95s [281] 0.1322852 0.4930147 0.1322852 0.0000000 0.6747076 0.6215810 0.6747076 95s [288] 0.1322852 0.6747076 0.1322852 0.1322852 0.1322852 0.6215810 0.0000000 95s [295] 0.0000000 0.6747076 0.6747076 0.4930147 0.0000000 0.4930147 0.6747076 95s [302] 0.6215810 0.6215810 0.0000000 0.1322852 0.4930147 0.4930147 0.6215810 95s [309] 0.2566014 0.6215810 0.4930147 0.4930147 0.6747076 0.0000000 0.6747076 95s [316] 0.1322852 0.6747076 0.1322852 0.4930147 0.0000000 0.2566014 0.1322852 95s [323] 0.0000000 0.6215810 0.6747076 0.6747076 0.6747076 0.1322852 0.2566014 95s [330] 0.0000000 0.0000000 0.4930147 0.4930147 0.4930147 0.0000000 0.4930147 95s [337] 0.0000000 0.6215810 0.2566014 0.6747076 0.4930147 0.4930147 0.2566014 95s [344] 0.0000000 0.0000000 0.6747076 0.0000000 0.0000000 0.4930147 0.0000000 95s [351] 0.1322852 0.1322852 0.2566014 0.6747076 0.3782613 0.0000000 0.3782613 95s [358] 0.3782613 0.4930147 0.1322852 0.4930147 0.1322852 0.6747076 0.0000000 95s [365] 0.4930147 0.0000000 0.1322852 0.0000000 0.1322852 0.2566014 0.0000000 95s [372] 0.2566014 0.2566014 0.6747076 0.6215810 0.0000000 0.6747076 0.0000000 95s [379] 0.1322852 0.6747076 0.1322852 0.4930147 0.1322852 0.1322852 0.4930147 95s [386] 0.1322852 0.1322852 0.0000000 0.6215810 0.0000000 0.4930147 0.0000000 95s [393] 0.6215810 0.2566014 0.6215810 0.6215810 0.2566014 0.2566014 0.1322852 95s [400] 0.1322852 0.6747076 0.6747076 0.2566014 0.4930147 0.3782613 0.6215810 95s [407] 0.6747076 0.2566014 0.1322852 0.0000000 0.2566014 0.2566014 0.6215810 95s [414] 0.1322852 0.0000000 0.0000000 0.0000000 0.0000000 0.1322852 0.1322852 95s [421] 0.0000000 0.1322852 0.1322852 0.4930147 0.6747076 0.6747076 0.6747076 95s [428] 0.0000000 0.6215810 0.6747076 0.6747076 0.0000000 0.0000000 0.6747076 95s [435] 0.4930147 0.2566014 0.0000000 0.0000000 0.1322852 0.0000000 0.6215810 95s [442] 0.4930147 0.6747076 0.1322852 0.4930147 0.0000000 0.6747076 0.0000000 95s [449] 0.2566014 0.4930147 0.2566014 0.4930147 0.6215810 0.4930147 0.4930147 95s [456] 0.0000000 0.0000000 0.1322852 0.0000000 0.1322852 0.0000000 0.0000000 95s [463] 0.0000000 0.6747076 0.2566014 0.6747076 0.4930147 0.4930147 0.1322852 95s [470] 0.6747076 0.0000000 0.1322852 0.0000000 0.2566014 0.0000000 0.0000000 95s [477] 0.1322852 0.6215810 0.1322852 0.4930147 0.0000000 0.1322852 0.4930147 95s [484] 0.2566014 0.6747076 0.3782613 0.6215810 0.6747076 0.6215810 0.0000000 95s [491] 0.0000000 0.1322852 0.1322852 0.6747076 0.0000000 0.2566014 0.4930147 95s [498] 0.4930147 0.4930147 0.1322852 0.1322852 0.1322852 0.6215810 0.0000000 95s [505] 0.2566014 0.1322852 0.6747076 0.1322852 0.4930147 0.4930147 0.6215810 95s [512] 0.0000000 0.4930147 0.6747076 0.2566014 0.0000000 0.1322852 0.0000000 95s [519] 0.6215810 0.0000000 0.4930147 0.4930147 0.0000000 0.6747076 0.0000000 95s [526] 0.3782613 0.0000000 0.1322852 0.6215810 0.1322852 0.1322852 0.1322852 95s [533] 0.6747076 0.6215810 0.0000000 0.0000000 0.0000000 0.6215810 0.2566014 95s [540] 0.6747076 0.6747076 0.2566014 0.0000000 0.0000000 0.1322852 0.4930147 95s [547] 0.4930147 0.0000000 0.1322852 0.6215810 0.0000000 0.0000000 0.1322852 95s [554] 0.0000000 0.0000000 0.0000000 0.6747076 0.6747076 0.6747076 0.4930147 95s [561] 0.0000000 0.6215810 0.0000000 0.1322852 0.1322852 0.4930147 0.2566014 95s [568] 0.4930147 0.1322852 0.1322852 0.0000000 0.6747076 0.2566014 0.6215810 95s [575] 0.0000000 0.3782613 0.1322852 0.1322852 0.0000000 0.4930147 0.1322852 95s [582] 0.4930147 0.1322852 0.0000000 0.2566014 0.0000000 0.1322852 0.6747076 95s [589] 0.1322852 0.4930147 0.4930147 0.6747076 0.1322852 0.3782613 0.0000000 95s [596] 0.6747076 0.0000000 0.2566014 0.3782613 0.3782613 0.0000000 0.0000000 95s [603] 0.0000000 0.4930147 0.6747076 0.4930147 0.4930147 0.2566014 0.2566014 95s [610] 0.6215810 0.1322852 0.2566014 0.2566014 0.3782613 0.6747076 0.6747076 95s [617] 0.0000000 0.1322852 0.4930147 0.6215810 0.1322852 0.0000000 0.6747076 95s [624] 0.4930147 0.2566014 0.6747076 0.6747076 0.0000000 0.2566014 0.6215810 95s [631] 0.2566014 0.2566014 0.0000000 0.6215810 0.6747076 0.0000000 0.1322852 95s [638] 0.6747076 95s 95s [1] 73.61884 95s [1] 4193.584 95s [1] 4193.584 95s Dose Response Model 95s 95s Model: linear 95s Fit-type: normal 95s 95s Residuals: 95s Min 1Q Median 3Q Max 95s -19.855 -3.996 -0.064 3.775 24.956 95s 95s Coefficients with approx. stand. error: 95s Estimate Std. Error 95s e0 -11.1996 0.811196 95s delta 0.0136 0.000532 95s age -0.0126 0.009027 95s centergreen 0.0191 0.793736 95s centerred 1.1979 0.810341 95s centersilver 0.7446 0.817870 95s centeryellow 1.2027 0.826882 95s 95s Residual standard error: 6.43 95s Degrees of freedom: 631 95s 95s Call: 95s lm(formula = y ~ x + age + center, data = datset) 95s 95s Residuals: 95s Min 1Q Median 3Q Max 95s -24.956 -3.775 0.064 3.996 19.855 95s 95s Coefficients: 95s Estimate Std. Error t value Pr(>|t|) 95s (Intercept) -1.120e+01 8.112e-01 -13.806 <2e-16 *** 95s x 1.360e-02 5.316e-04 25.575 <2e-16 *** 95s age -1.255e-02 9.027e-03 -1.391 0.165 95s centergreen 1.906e-02 7.937e-01 0.024 0.981 95s centerred 1.198e+00 8.103e-01 1.478 0.140 95s centersilver 7.446e-01 8.179e-01 0.910 0.363 95s centeryellow 1.203e+00 8.269e-01 1.455 0.146 95s --- 95s Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 95s 95s Residual standard error: 6.427 on 631 degrees of freedom 95s Multiple R-squared: 0.5116, Adjusted R-squared: 0.507 95s F-statistic: 110.2 on 6 and 631 DF, p-value: < 2.2e-16 95s 95s e0 delta age centergreen 95s e0 0.6580393306 -1.631958e-04 -4.307448e-03 -3.626158e-01 95s delta -0.0001631958 2.826129e-07 -4.180339e-09 -8.076204e-07 95s age -0.0043074482 -4.180339e-09 8.148624e-05 5.148937e-04 95s centergreen -0.3626157873 -8.076204e-07 5.148937e-04 6.300174e-01 95s centerred -0.3460806667 -1.885394e-06 2.140485e-04 3.372074e-01 95s centersilver -0.3642369060 1.847581e-05 3.347250e-04 3.379136e-01 95s centeryellow -0.3253014822 3.596102e-06 -2.387489e-04 3.343312e-01 95s centerred centersilver centeryellow 95s e0 -3.460807e-01 -3.642369e-01 -3.253015e-01 95s delta -1.885394e-06 1.847581e-05 3.596102e-06 95s age 2.140485e-04 3.347250e-04 -2.387489e-04 95s centergreen 3.372074e-01 3.379136e-01 3.343312e-01 95s centerred 6.566532e-01 3.366063e-01 3.351988e-01 95s centersilver 3.366063e-01 6.689109e-01 3.351035e-01 95s centeryellow 3.351988e-01 3.351035e-01 6.837334e-01 95s (Intercept) x age centergreen 95s (Intercept) 0.6580393306 -1.631958e-04 -4.307448e-03 -3.626158e-01 95s x -0.0001631958 2.826129e-07 -4.180339e-09 -8.076204e-07 95s age -0.0043074482 -4.180339e-09 8.148624e-05 5.148937e-04 95s centergreen -0.3626157873 -8.076204e-07 5.148937e-04 6.300174e-01 95s centerred -0.3460806667 -1.885394e-06 2.140485e-04 3.372074e-01 95s centersilver -0.3642369060 1.847581e-05 3.347250e-04 3.379136e-01 95s centeryellow -0.3253014822 3.596102e-06 -2.387489e-04 3.343312e-01 95s centerred centersilver centeryellow 95s (Intercept) -3.460807e-01 -3.642369e-01 -3.253015e-01 95s x -1.885394e-06 1.847581e-05 3.596102e-06 95s age 2.140485e-04 3.347250e-04 -2.387489e-04 95s centergreen 3.372074e-01 3.379136e-01 3.343312e-01 95s centerred 6.566532e-01 3.366063e-01 3.351988e-01 95s centersilver 3.366063e-01 6.689109e-01 3.351035e-01 95s centeryellow 3.351988e-01 3.351035e-01 6.837334e-01 95s $fit 95s [1] 3.385405 6.566871 12.617093 12.617093 17.266927 0.000000 0.000000 95s [8] 6.566871 17.266927 3.385405 15.907326 3.385405 0.000000 9.680356 95s [15] 15.907326 17.266927 12.617093 17.266927 3.385405 17.266927 17.266927 95s [22] 9.680356 3.385405 12.617093 0.000000 12.617093 3.385405 6.566871 95s [29] 0.000000 17.266927 0.000000 9.680356 12.617093 3.385405 3.385405 95s [36] 0.000000 0.000000 12.617093 0.000000 12.617093 0.000000 15.907326 95s [43] 12.617093 15.907326 3.385405 17.266927 17.266927 6.566871 3.385405 95s [50] 0.000000 9.680356 17.266927 15.907326 0.000000 3.385405 17.266927 95s [57] 6.566871 17.266927 0.000000 3.385405 12.617093 12.617093 0.000000 95s [64] 0.000000 15.907326 15.907326 0.000000 12.617093 15.907326 3.385405 95s [71] 15.907326 6.566871 3.385405 17.266927 12.617093 0.000000 12.617093 95s [78] 12.617093 3.385405 0.000000 0.000000 0.000000 3.385405 3.385405 95s [85] 3.385405 6.566871 3.385405 0.000000 3.385405 17.266927 6.566871 95s [92] 3.385405 17.266927 9.680356 3.385405 0.000000 3.385405 3.385405 95s [99] 12.617093 0.000000 3.385405 3.385405 12.617093 0.000000 0.000000 95s [106] 17.266927 0.000000 6.566871 15.907326 17.266927 3.385405 17.266927 95s [113] 3.385405 0.000000 0.000000 3.385405 6.566871 0.000000 6.566871 95s [120] 3.385405 0.000000 0.000000 6.566871 15.907326 12.617093 12.617093 95s [127] 0.000000 17.266927 0.000000 17.266927 3.385405 0.000000 12.617093 95s [134] 17.266927 0.000000 3.385405 0.000000 6.566871 6.566871 6.566871 95s [141] 3.385405 17.266927 0.000000 0.000000 3.385405 0.000000 15.907326 95s [148] 17.266927 3.385405 15.907326 0.000000 17.266927 6.566871 3.385405 95s [155] 12.617093 6.566871 6.566871 3.385405 3.385405 0.000000 3.385405 95s [162] 0.000000 3.385405 12.617093 3.385405 0.000000 17.266927 0.000000 95s [169] 0.000000 3.385405 17.266927 3.385405 17.266927 15.907326 6.566871 95s [176] 12.617093 3.385405 0.000000 12.617093 0.000000 12.617093 17.266927 95s [183] 12.617093 0.000000 0.000000 12.617093 3.385405 12.617093 17.266927 95s [190] 3.385405 3.385405 17.266927 3.385405 6.566871 3.385405 17.266927 95s [197] 17.266927 0.000000 12.617093 0.000000 12.617093 3.385405 6.566871 95s [204] 12.617093 12.617093 3.385405 3.385405 12.617093 17.266927 12.617093 95s [211] 3.385405 3.385405 17.266927 0.000000 6.566871 3.385405 3.385405 95s [218] 0.000000 6.566871 0.000000 6.566871 6.566871 3.385405 0.000000 95s [225] 3.385405 3.385405 17.266927 3.385405 0.000000 17.266927 3.385405 95s [232] 6.566871 17.266927 0.000000 0.000000 3.385405 3.385405 12.617093 95s [239] 6.566871 12.617093 3.385405 12.617093 17.266927 6.566871 17.266927 95s [246] 17.266927 15.907326 0.000000 3.385405 3.385405 3.385405 0.000000 95s [253] 12.617093 15.907326 6.566871 3.385405 3.385405 0.000000 0.000000 95s [260] 12.617093 6.566871 3.385405 3.385405 12.617093 17.266927 0.000000 95s [267] 6.566871 15.907326 3.385405 15.907326 3.385405 12.617093 0.000000 95s [274] 17.266927 15.907326 6.566871 3.385405 12.617093 0.000000 3.385405 95s [281] 3.385405 12.617093 3.385405 0.000000 17.266927 15.907326 17.266927 95s [288] 3.385405 17.266927 3.385405 3.385405 3.385405 15.907326 0.000000 95s [295] 0.000000 17.266927 17.266927 12.617093 0.000000 12.617093 17.266927 95s [302] 15.907326 15.907326 0.000000 3.385405 12.617093 12.617093 15.907326 95s [309] 6.566871 15.907326 12.617093 12.617093 17.266927 0.000000 17.266927 95s [316] 3.385405 17.266927 3.385405 12.617093 0.000000 6.566871 3.385405 95s [323] 0.000000 15.907326 17.266927 17.266927 17.266927 3.385405 6.566871 95s [330] 0.000000 0.000000 12.617093 12.617093 12.617093 0.000000 12.617093 95s [337] 0.000000 15.907326 6.566871 17.266927 12.617093 12.617093 6.566871 95s [344] 0.000000 0.000000 17.266927 0.000000 0.000000 12.617093 0.000000 95s [351] 3.385405 3.385405 6.566871 17.266927 9.680356 0.000000 9.680356 95s [358] 9.680356 12.617093 3.385405 12.617093 3.385405 17.266927 0.000000 95s [365] 12.617093 0.000000 3.385405 0.000000 3.385405 6.566871 0.000000 95s [372] 6.566871 6.566871 17.266927 15.907326 0.000000 17.266927 0.000000 95s [379] 3.385405 17.266927 3.385405 12.617093 3.385405 3.385405 12.617093 95s [386] 3.385405 3.385405 0.000000 15.907326 0.000000 12.617093 0.000000 95s [393] 15.907326 6.566871 15.907326 15.907326 6.566871 6.566871 3.385405 95s [400] 3.385405 17.266927 17.266927 6.566871 12.617093 9.680356 15.907326 95s [407] 17.266927 6.566871 3.385405 0.000000 6.566871 6.566871 15.907326 95s [414] 3.385405 0.000000 0.000000 0.000000 0.000000 3.385405 3.385405 95s [421] 0.000000 3.385405 3.385405 12.617093 17.266927 17.266927 17.266927 95s [428] 0.000000 15.907326 17.266927 17.266927 0.000000 0.000000 17.266927 95s [435] 12.617093 6.566871 0.000000 0.000000 3.385405 0.000000 15.907326 95s [442] 12.617093 17.266927 3.385405 12.617093 0.000000 17.266927 0.000000 95s [449] 6.566871 12.617093 6.566871 12.617093 15.907326 12.617093 12.617093 95s [456] 0.000000 0.000000 3.385405 0.000000 3.385405 0.000000 0.000000 95s [463] 0.000000 17.266927 6.566871 17.266927 12.617093 12.617093 3.385405 95s [470] 17.266927 0.000000 3.385405 0.000000 6.566871 0.000000 0.000000 95s [477] 3.385405 15.907326 3.385405 12.617093 0.000000 3.385405 12.617093 95s [484] 6.566871 17.266927 9.680356 15.907326 17.266927 15.907326 0.000000 95s [491] 0.000000 3.385405 3.385405 17.266927 0.000000 6.566871 12.617093 95s [498] 12.617093 12.617093 3.385405 3.385405 3.385405 15.907326 0.000000 95s [505] 6.566871 3.385405 17.266927 3.385405 12.617093 12.617093 15.907326 95s [512] 0.000000 12.617093 17.266927 6.566871 0.000000 3.385405 0.000000 95s [519] 15.907326 0.000000 12.617093 12.617093 0.000000 17.266927 0.000000 95s [526] 9.680356 0.000000 3.385405 15.907326 3.385405 3.385405 3.385405 95s [533] 17.266927 15.907326 0.000000 0.000000 0.000000 15.907326 6.566871 95s [540] 17.266927 17.266927 6.566871 0.000000 0.000000 3.385405 12.617093 95s [547] 12.617093 0.000000 3.385405 15.907326 0.000000 0.000000 3.385405 95s [554] 0.000000 0.000000 0.000000 17.266927 17.266927 17.266927 12.617093 95s [561] 0.000000 15.907326 0.000000 3.385405 3.385405 12.617093 6.566871 95s [568] 12.617093 3.385405 3.385405 0.000000 17.266927 6.566871 15.907326 95s [575] 0.000000 9.680356 3.385405 3.385405 0.000000 12.617093 3.385405 95s [582] 12.617093 3.385405 0.000000 6.566871 0.000000 3.385405 17.266927 95s [589] 3.385405 12.617093 12.617093 17.266927 3.385405 9.680356 0.000000 95s [596] 17.266927 0.000000 6.566871 9.680356 9.680356 0.000000 0.000000 95s [603] 0.000000 12.617093 17.266927 12.617093 12.617093 6.566871 6.566871 95s [610] 15.907326 3.385405 6.566871 6.566871 9.680356 17.266927 17.266927 95s [617] 0.000000 3.385405 12.617093 15.907326 3.385405 0.000000 17.266927 95s [624] 12.617093 6.566871 17.266927 17.266927 0.000000 6.566871 15.907326 95s [631] 6.566871 6.566871 0.000000 15.907326 17.266927 0.000000 3.385405 95s [638] 17.266927 95s 95s $se.fit 95s [1] 0.1323718 0.2567693 0.4933373 0.4933373 0.6751491 0.0000000 0.0000000 95s [8] 0.2567693 0.6751491 0.1323718 0.6219878 0.1323718 0.0000000 0.3785088 95s [15] 0.6219878 0.6751491 0.4933373 0.6751491 0.1323718 0.6751491 0.6751491 95s [22] 0.3785088 0.1323718 0.4933373 0.0000000 0.4933373 0.1323718 0.2567693 95s [29] 0.0000000 0.6751491 0.0000000 0.3785088 0.4933373 0.1323718 0.1323718 95s [36] 0.0000000 0.0000000 0.4933373 0.0000000 0.4933373 0.0000000 0.6219878 95s [43] 0.4933373 0.6219878 0.1323718 0.6751491 0.6751491 0.2567693 0.1323718 95s [50] 0.0000000 0.3785088 0.6751491 0.6219878 0.0000000 0.1323718 0.6751491 95s [57] 0.2567693 0.6751491 0.0000000 0.1323718 0.4933373 0.4933373 0.0000000 95s [64] 0.0000000 0.6219878 0.6219878 0.0000000 0.4933373 0.6219878 0.1323718 95s [71] 0.6219878 0.2567693 0.1323718 0.6751491 0.4933373 0.0000000 0.4933373 95s [78] 0.4933373 0.1323718 0.0000000 0.0000000 0.0000000 0.1323718 0.1323718 95s [85] 0.1323718 0.2567693 0.1323718 0.0000000 0.1323718 0.6751491 0.2567693 95s [92] 0.1323718 0.6751491 0.3785088 0.1323718 0.0000000 0.1323718 0.1323718 95s [99] 0.4933373 0.0000000 0.1323718 0.1323718 0.4933373 0.0000000 0.0000000 95s [106] 0.6751491 0.0000000 0.2567693 0.6219878 0.6751491 0.1323718 0.6751491 95s [113] 0.1323718 0.0000000 0.0000000 0.1323718 0.2567693 0.0000000 0.2567693 95s [120] 0.1323718 0.0000000 0.0000000 0.2567693 0.6219878 0.4933373 0.4933373 95s [127] 0.0000000 0.6751491 0.0000000 0.6751491 0.1323718 0.0000000 0.4933373 95s [134] 0.6751491 0.0000000 0.1323718 0.0000000 0.2567693 0.2567693 0.2567693 95s [141] 0.1323718 0.6751491 0.0000000 0.0000000 0.1323718 0.0000000 0.6219878 95s [148] 0.6751491 0.1323718 0.6219878 0.0000000 0.6751491 0.2567693 0.1323718 95s [155] 0.4933373 0.2567693 0.2567693 0.1323718 0.1323718 0.0000000 0.1323718 95s [162] 0.0000000 0.1323718 0.4933373 0.1323718 0.0000000 0.6751491 0.0000000 95s [169] 0.0000000 0.1323718 0.6751491 0.1323718 0.6751491 0.6219878 0.2567693 95s [176] 0.4933373 0.1323718 0.0000000 0.4933373 0.0000000 0.4933373 0.6751491 95s [183] 0.4933373 0.0000000 0.0000000 0.4933373 0.1323718 0.4933373 0.6751491 95s [190] 0.1323718 0.1323718 0.6751491 0.1323718 0.2567693 0.1323718 0.6751491 95s [197] 0.6751491 0.0000000 0.4933373 0.0000000 0.4933373 0.1323718 0.2567693 95s [204] 0.4933373 0.4933373 0.1323718 0.1323718 0.4933373 0.6751491 0.4933373 95s [211] 0.1323718 0.1323718 0.6751491 0.0000000 0.2567693 0.1323718 0.1323718 95s [218] 0.0000000 0.2567693 0.0000000 0.2567693 0.2567693 0.1323718 0.0000000 95s [225] 0.1323718 0.1323718 0.6751491 0.1323718 0.0000000 0.6751491 0.1323718 95s [232] 0.2567693 0.6751491 0.0000000 0.0000000 0.1323718 0.1323718 0.4933373 95s [239] 0.2567693 0.4933373 0.1323718 0.4933373 0.6751491 0.2567693 0.6751491 95s [246] 0.6751491 0.6219878 0.0000000 0.1323718 0.1323718 0.1323718 0.0000000 95s [253] 0.4933373 0.6219878 0.2567693 0.1323718 0.1323718 0.0000000 0.0000000 95s [260] 0.4933373 0.2567693 0.1323718 0.1323718 0.4933373 0.6751491 0.0000000 95s [267] 0.2567693 0.6219878 0.1323718 0.6219878 0.1323718 0.4933373 0.0000000 95s [274] 0.6751491 0.6219878 0.2567693 0.1323718 0.4933373 0.0000000 0.1323718 95s [281] 0.1323718 0.4933373 0.1323718 0.0000000 0.6751491 0.6219878 0.6751491 95s [288] 0.1323718 0.6751491 0.1323718 0.1323718 0.1323718 0.6219878 0.0000000 95s [295] 0.0000000 0.6751491 0.6751491 0.4933373 0.0000000 0.4933373 0.6751491 95s [302] 0.6219878 0.6219878 0.0000000 0.1323718 0.4933373 0.4933373 0.6219878 95s [309] 0.2567693 0.6219878 0.4933373 0.4933373 0.6751491 0.0000000 0.6751491 95s [316] 0.1323718 0.6751491 0.1323718 0.4933373 0.0000000 0.2567693 0.1323718 95s [323] 0.0000000 0.6219878 0.6751491 0.6751491 0.6751491 0.1323718 0.2567693 95s [330] 0.0000000 0.0000000 0.4933373 0.4933373 0.4933373 0.0000000 0.4933373 95s [337] 0.0000000 0.6219878 0.2567693 0.6751491 0.4933373 0.4933373 0.2567693 95s [344] 0.0000000 0.0000000 0.6751491 0.0000000 0.0000000 0.4933373 0.0000000 95s [351] 0.1323718 0.1323718 0.2567693 0.6751491 0.3785088 0.0000000 0.3785088 95s [358] 0.3785088 0.4933373 0.1323718 0.4933373 0.1323718 0.6751491 0.0000000 95s [365] 0.4933373 0.0000000 0.1323718 0.0000000 0.1323718 0.2567693 0.0000000 95s [372] 0.2567693 0.2567693 0.6751491 0.6219878 0.0000000 0.6751491 0.0000000 95s [379] 0.1323718 0.6751491 0.1323718 0.4933373 0.1323718 0.1323718 0.4933373 95s [386] 0.1323718 0.1323718 0.0000000 0.6219878 0.0000000 0.4933373 0.0000000 95s [393] 0.6219878 0.2567693 0.6219878 0.6219878 0.2567693 0.2567693 0.1323718 95s [400] 0.1323718 0.6751491 0.6751491 0.2567693 0.4933373 0.3785088 0.6219878 95s [407] 0.6751491 0.2567693 0.1323718 0.0000000 0.2567693 0.2567693 0.6219878 95s [414] 0.1323718 0.0000000 0.0000000 0.0000000 0.0000000 0.1323718 0.1323718 95s [421] 0.0000000 0.1323718 0.1323718 0.4933373 0.6751491 0.6751491 0.6751491 95s [428] 0.0000000 0.6219878 0.6751491 0.6751491 0.0000000 0.0000000 0.6751491 95s [435] 0.4933373 0.2567693 0.0000000 0.0000000 0.1323718 0.0000000 0.6219878 95s [442] 0.4933373 0.6751491 0.1323718 0.4933373 0.0000000 0.6751491 0.0000000 95s [449] 0.2567693 0.4933373 0.2567693 0.4933373 0.6219878 0.4933373 0.4933373 95s [456] 0.0000000 0.0000000 0.1323718 0.0000000 0.1323718 0.0000000 0.0000000 95s [463] 0.0000000 0.6751491 0.2567693 0.6751491 0.4933373 0.4933373 0.1323718 95s [470] 0.6751491 0.0000000 0.1323718 0.0000000 0.2567693 0.0000000 0.0000000 95s [477] 0.1323718 0.6219878 0.1323718 0.4933373 0.0000000 0.1323718 0.4933373 95s [484] 0.2567693 0.6751491 0.3785088 0.6219878 0.6751491 0.6219878 0.0000000 95s [491] 0.0000000 0.1323718 0.1323718 0.6751491 0.0000000 0.2567693 0.4933373 95s [498] 0.4933373 0.4933373 0.1323718 0.1323718 0.1323718 0.6219878 0.0000000 95s [505] 0.2567693 0.1323718 0.6751491 0.1323718 0.4933373 0.4933373 0.6219878 95s [512] 0.0000000 0.4933373 0.6751491 0.2567693 0.0000000 0.1323718 0.0000000 95s [519] 0.6219878 0.0000000 0.4933373 0.4933373 0.0000000 0.6751491 0.0000000 95s [526] 0.3785088 0.0000000 0.1323718 0.6219878 0.1323718 0.1323718 0.1323718 95s [533] 0.6751491 0.6219878 0.0000000 0.0000000 0.0000000 0.6219878 0.2567693 95s [540] 0.6751491 0.6751491 0.2567693 0.0000000 0.0000000 0.1323718 0.4933373 95s [547] 0.4933373 0.0000000 0.1323718 0.6219878 0.0000000 0.0000000 0.1323718 95s [554] 0.0000000 0.0000000 0.0000000 0.6751491 0.6751491 0.6751491 0.4933373 95s [561] 0.0000000 0.6219878 0.0000000 0.1323718 0.1323718 0.4933373 0.2567693 95s [568] 0.4933373 0.1323718 0.1323718 0.0000000 0.6751491 0.2567693 0.6219878 95s [575] 0.0000000 0.3785088 0.1323718 0.1323718 0.0000000 0.4933373 0.1323718 95s [582] 0.4933373 0.1323718 0.0000000 0.2567693 0.0000000 0.1323718 0.6751491 95s [589] 0.1323718 0.4933373 0.4933373 0.6751491 0.1323718 0.3785088 0.0000000 95s [596] 0.6751491 0.0000000 0.2567693 0.3785088 0.3785088 0.0000000 0.0000000 95s [603] 0.0000000 0.4933373 0.6751491 0.4933373 0.4933373 0.2567693 0.2567693 95s [610] 0.6219878 0.1323718 0.2567693 0.2567693 0.3785088 0.6751491 0.6751491 95s [617] 0.0000000 0.1323718 0.4933373 0.6219878 0.1323718 0.0000000 0.6751491 95s [624] 0.4933373 0.2567693 0.6751491 0.6751491 0.0000000 0.2567693 0.6219878 95s [631] 0.2567693 0.2567693 0.0000000 0.6219878 0.6751491 0.0000000 0.1323718 95s [638] 0.6751491 95s 95s $fit 95s [1] -11.57621 -11.56261 -11.54901 -10.21661 95s 95s $se.fit 95s [1] 0.6876991 0.6874618 0.6872248 0.6656515 95s 95s $fit 95s 1 2 3 4 95s -11.57621 -11.56261 -11.54901 -10.21661 95s 95s $se.fit 95s 1 2 3 4 95s 0.6876991 0.6874618 0.6872248 0.6656515 95s 95s $df 95s [1] 631 95s 95s $residual.scale 95s [1] 6.427248 95s 95s [1] 73.55102 95s [1] 2768.739 95s [1] 2768.739 95s Dose Response Model 95s 95s Model: linlog 95s Fit-type: normal 95s 95s Residuals: 95s Min 1Q Median 3Q Max 95s -18.804 -3.875 -0.163 4.453 17.258 95s 95s Coefficients with approx. stand. error: 95s Estimate Std. Error 95s e0 -13.65 2.626 95s delta 2.21 0.402 95s 95s Residual standard error: 6.12 95s Degrees of freedom: 426 95s 95s Call: 95s lm(formula = y ~ log(x + off), data = datset) 95s 95s Residuals: 95s Min 1Q Median 3Q Max 95s -17.2582 -4.4526 0.1627 3.8749 18.8035 95s 95s Coefficients: 95s Estimate Std. Error t value Pr(>|t|) 95s (Intercept) -13.6486 2.6260 -5.197 3.14e-07 *** 95s log(x + off) 2.2117 0.4016 5.508 6.29e-08 *** 95s --- 95s Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 95s 95s Residual standard error: 6.116 on 426 degrees of freedom 95s Multiple R-squared: 0.06648, Adjusted R-squared: 0.06429 95s F-statistic: 30.34 on 1 and 426 DF, p-value: 6.29e-08 95s 95s e0 delta 95s e0 6.896082 -1.0477868 95s delta -1.047787 0.1612436 95s (Intercept) log(x + off) 95s (Intercept) 6.896082 -1.0477868 95s log(x + off) -1.047787 0.1612436 95s $fit 95s [1] 6.008369 5.658359 0.000000 4.514640 4.877164 4.115493 6.008369 6.641510 95s [9] 0.000000 4.115493 5.658359 6.247655 4.514640 6.247655 4.514640 4.514640 95s [17] 4.115493 0.000000 6.008369 4.877164 4.877164 6.247655 6.733679 6.247655 95s [25] 4.115493 4.877164 0.000000 6.733679 6.641510 4.514640 4.514640 5.658359 95s [33] 6.008369 4.877164 4.877164 0.000000 6.008369 6.733679 4.877164 6.008369 95s [41] 6.733679 4.877164 6.008369 6.008369 4.877164 5.658359 4.514640 4.877164 95s [49] 0.000000 4.514640 5.658359 0.000000 4.877164 6.733679 4.877164 4.514640 95s [57] 4.877164 5.658359 6.641510 4.877164 6.733679 5.658359 0.000000 6.247655 95s [65] 6.247655 5.658359 4.877164 4.877164 4.115493 4.877164 6.733679 6.247655 95s [73] 5.658359 5.658359 4.877164 5.535104 6.008369 5.535104 6.247655 6.008369 95s [81] 6.247655 6.008369 5.535104 4.115493 5.658359 4.877164 6.008369 4.877164 95s [89] 6.247655 0.000000 6.008369 4.514640 4.514640 6.008369 4.877164 5.658359 95s [97] 4.877164 6.008369 6.733679 5.658359 4.115493 6.247655 0.000000 6.008369 95s [105] 6.247655 4.877164 6.733679 5.658359 4.115493 5.658359 5.658359 5.658359 95s [113] 6.008369 6.008369 6.733679 4.115493 4.877164 4.115493 4.877164 5.658359 95s [121] 4.514640 6.247655 4.877164 6.641510 4.115493 4.877164 5.658359 4.877164 95s [129] 4.514640 0.000000 6.008369 4.514640 6.733679 4.877164 4.514640 4.877164 95s [137] 5.658359 5.658359 4.115493 6.247655 6.641510 4.877164 5.658359 4.514640 95s [145] 4.115493 4.115493 6.733679 4.877164 0.000000 4.877164 5.658359 4.514640 95s [153] 6.641510 4.514640 4.877164 4.115493 6.247655 4.115493 6.008369 4.877164 95s [161] 4.514640 4.115493 4.877164 6.733679 6.247655 4.514640 4.877164 5.658359 95s [169] 4.115493 0.000000 5.658359 5.658359 4.877164 4.514640 4.115493 4.877164 95s [177] 0.000000 5.658359 6.247655 6.733679 0.000000 6.008369 4.514640 4.877164 95s [185] 0.000000 6.733679 5.658359 6.247655 4.514640 5.535104 5.658359 4.877164 95s [193] 5.658359 6.733679 6.641510 4.514640 6.008369 4.115493 4.877164 4.877164 95s [201] 4.115493 6.247655 5.658359 6.247655 5.535104 0.000000 4.115493 6.641510 95s [209] 6.247655 6.008369 4.115493 4.514640 4.514640 6.641510 6.733679 6.733679 95s [217] 5.658359 5.658359 6.008369 4.115493 5.658359 6.641510 6.641510 4.877164 95s [225] 0.000000 4.877164 0.000000 4.115493 4.877164 5.535104 4.115493 5.658359 95s [233] 6.733679 4.514640 6.733679 4.514640 4.514640 5.658359 6.008369 5.658359 95s [241] 4.877164 4.514640 4.115493 4.115493 4.115493 6.247655 5.658359 0.000000 95s [249] 4.115493 4.514640 6.247655 6.733679 6.008369 4.877164 4.115493 4.514640 95s [257] 0.000000 0.000000 5.658359 5.658359 4.514640 5.658359 4.514640 4.115493 95s [265] 4.877164 4.877164 4.514640 5.658359 6.008369 4.514640 4.115493 0.000000 95s [273] 4.877164 4.877164 4.115493 6.008369 4.514640 6.008369 4.514640 4.877164 95s [281] 6.008369 0.000000 0.000000 5.658359 6.247655 6.008369 6.008369 6.247655 95s [289] 4.877164 4.877164 4.514640 6.008369 6.008369 4.115493 6.641510 6.733679 95s [297] 4.514640 4.877164 4.877164 4.877164 6.008369 6.641510 4.877164 5.658359 95s [305] 4.514640 5.535104 4.877164 6.008369 6.008369 5.658359 4.514640 6.008369 95s [313] 6.247655 5.658359 6.733679 6.008369 6.247655 5.658359 5.535104 4.877164 95s [321] 5.658359 4.877164 4.877164 5.658359 5.658359 4.877164 4.115493 4.877164 95s [329] 5.658359 4.877164 4.877164 4.877164 5.658359 6.733679 6.008369 6.247655 95s [337] 4.877164 5.535104 6.008369 4.115493 6.008369 6.247655 4.115493 6.008369 95s [345] 5.658359 4.877164 6.247655 6.641510 5.658359 4.115493 6.733679 6.008369 95s [353] 5.658359 4.115493 4.514640 4.877164 6.733679 5.658359 0.000000 6.641510 95s [361] 6.733679 4.115493 6.247655 4.877164 4.877164 5.658359 4.514640 4.115493 95s [369] 4.877164 4.877164 4.877164 5.658359 4.877164 0.000000 5.658359 4.877164 95s [377] 4.877164 4.514640 4.514640 6.733679 6.008369 6.733679 4.514640 4.514640 95s [385] 4.115493 5.535104 4.877164 4.877164 6.247655 5.658359 6.733679 4.514640 95s [393] 4.877164 5.658359 6.733679 6.733679 4.514640 6.008369 5.658359 6.733679 95s [401] 6.733679 6.733679 0.000000 6.641510 6.733679 4.115493 4.877164 6.247655 95s [409] 0.000000 4.115493 4.514640 4.877164 4.877164 4.514640 6.733679 6.247655 95s [417] 5.658359 4.877164 4.877164 0.000000 4.877164 4.877164 0.000000 6.008369 95s [425] 4.115493 4.514640 4.877164 0.000000 95s 95s $se.fit 95s [1] 1.0908488 1.0273028 0.0000000 0.8196550 0.8854731 0.7471878 1.0908488 95s [8] 1.2057987 0.0000000 0.7471878 1.0273028 1.1342924 0.8196550 1.1342924 95s [15] 0.8196550 0.8196550 0.7471878 0.0000000 1.0908488 0.8854731 0.8854731 95s [22] 1.1342924 1.2225325 1.1342924 0.7471878 0.8854731 0.0000000 1.2225325 95s [29] 1.2057987 0.8196550 0.8196550 1.0273028 1.0908488 0.8854731 0.8854731 95s [36] 0.0000000 1.0908488 1.2225325 0.8854731 1.0908488 1.2225325 0.8854731 95s [43] 1.0908488 1.0908488 0.8854731 1.0273028 0.8196550 0.8854731 0.0000000 95s [50] 0.8196550 1.0273028 0.0000000 0.8854731 1.2225325 0.8854731 0.8196550 95s [57] 0.8854731 1.0273028 1.2057987 0.8854731 1.2225325 1.0273028 0.0000000 95s [64] 1.1342924 1.1342924 1.0273028 0.8854731 0.8854731 0.7471878 0.8854731 95s [71] 1.2225325 1.1342924 1.0273028 1.0273028 0.8854731 1.0049252 1.0908488 95s [78] 1.0049252 1.1342924 1.0908488 1.1342924 1.0908488 1.0049252 0.7471878 95s [85] 1.0273028 0.8854731 1.0908488 0.8854731 1.1342924 0.0000000 1.0908488 95s [92] 0.8196550 0.8196550 1.0908488 0.8854731 1.0273028 0.8854731 1.0908488 95s [99] 1.2225325 1.0273028 0.7471878 1.1342924 0.0000000 1.0908488 1.1342924 95s [106] 0.8854731 1.2225325 1.0273028 0.7471878 1.0273028 1.0273028 1.0273028 95s [113] 1.0908488 1.0908488 1.2225325 0.7471878 0.8854731 0.7471878 0.8854731 95s [120] 1.0273028 0.8196550 1.1342924 0.8854731 1.2057987 0.7471878 0.8854731 95s [127] 1.0273028 0.8854731 0.8196550 0.0000000 1.0908488 0.8196550 1.2225325 95s [134] 0.8854731 0.8196550 0.8854731 1.0273028 1.0273028 0.7471878 1.1342924 95s [141] 1.2057987 0.8854731 1.0273028 0.8196550 0.7471878 0.7471878 1.2225325 95s [148] 0.8854731 0.0000000 0.8854731 1.0273028 0.8196550 1.2057987 0.8196550 95s [155] 0.8854731 0.7471878 1.1342924 0.7471878 1.0908488 0.8854731 0.8196550 95s [162] 0.7471878 0.8854731 1.2225325 1.1342924 0.8196550 0.8854731 1.0273028 95s [169] 0.7471878 0.0000000 1.0273028 1.0273028 0.8854731 0.8196550 0.7471878 95s [176] 0.8854731 0.0000000 1.0273028 1.1342924 1.2225325 0.0000000 1.0908488 95s [183] 0.8196550 0.8854731 0.0000000 1.2225325 1.0273028 1.1342924 0.8196550 95s [190] 1.0049252 1.0273028 0.8854731 1.0273028 1.2225325 1.2057987 0.8196550 95s [197] 1.0908488 0.7471878 0.8854731 0.8854731 0.7471878 1.1342924 1.0273028 95s [204] 1.1342924 1.0049252 0.0000000 0.7471878 1.2057987 1.1342924 1.0908488 95s [211] 0.7471878 0.8196550 0.8196550 1.2057987 1.2225325 1.2225325 1.0273028 95s [218] 1.0273028 1.0908488 0.7471878 1.0273028 1.2057987 1.2057987 0.8854731 95s [225] 0.0000000 0.8854731 0.0000000 0.7471878 0.8854731 1.0049252 0.7471878 95s [232] 1.0273028 1.2225325 0.8196550 1.2225325 0.8196550 0.8196550 1.0273028 95s [239] 1.0908488 1.0273028 0.8854731 0.8196550 0.7471878 0.7471878 0.7471878 95s [246] 1.1342924 1.0273028 0.0000000 0.7471878 0.8196550 1.1342924 1.2225325 95s [253] 1.0908488 0.8854731 0.7471878 0.8196550 0.0000000 0.0000000 1.0273028 95s [260] 1.0273028 0.8196550 1.0273028 0.8196550 0.7471878 0.8854731 0.8854731 95s [267] 0.8196550 1.0273028 1.0908488 0.8196550 0.7471878 0.0000000 0.8854731 95s [274] 0.8854731 0.7471878 1.0908488 0.8196550 1.0908488 0.8196550 0.8854731 95s [281] 1.0908488 0.0000000 0.0000000 1.0273028 1.1342924 1.0908488 1.0908488 95s [288] 1.1342924 0.8854731 0.8854731 0.8196550 1.0908488 1.0908488 0.7471878 95s [295] 1.2057987 1.2225325 0.8196550 0.8854731 0.8854731 0.8854731 1.0908488 95s [302] 1.2057987 0.8854731 1.0273028 0.8196550 1.0049252 0.8854731 1.0908488 95s [309] 1.0908488 1.0273028 0.8196550 1.0908488 1.1342924 1.0273028 1.2225325 95s [316] 1.0908488 1.1342924 1.0273028 1.0049252 0.8854731 1.0273028 0.8854731 95s [323] 0.8854731 1.0273028 1.0273028 0.8854731 0.7471878 0.8854731 1.0273028 95s [330] 0.8854731 0.8854731 0.8854731 1.0273028 1.2225325 1.0908488 1.1342924 95s [337] 0.8854731 1.0049252 1.0908488 0.7471878 1.0908488 1.1342924 0.7471878 95s [344] 1.0908488 1.0273028 0.8854731 1.1342924 1.2057987 1.0273028 0.7471878 95s [351] 1.2225325 1.0908488 1.0273028 0.7471878 0.8196550 0.8854731 1.2225325 95s [358] 1.0273028 0.0000000 1.2057987 1.2225325 0.7471878 1.1342924 0.8854731 95s [365] 0.8854731 1.0273028 0.8196550 0.7471878 0.8854731 0.8854731 0.8854731 95s [372] 1.0273028 0.8854731 0.0000000 1.0273028 0.8854731 0.8854731 0.8196550 95s [379] 0.8196550 1.2225325 1.0908488 1.2225325 0.8196550 0.8196550 0.7471878 95s [386] 1.0049252 0.8854731 0.8854731 1.1342924 1.0273028 1.2225325 0.8196550 95s [393] 0.8854731 1.0273028 1.2225325 1.2225325 0.8196550 1.0908488 1.0273028 95s [400] 1.2225325 1.2225325 1.2225325 0.0000000 1.2057987 1.2225325 0.7471878 95s [407] 0.8854731 1.1342924 0.0000000 0.7471878 0.8196550 0.8854731 0.8854731 95s [414] 0.8196550 1.2225325 1.1342924 1.0273028 0.8854731 0.8854731 0.0000000 95s [421] 0.8854731 0.8854731 0.0000000 1.0908488 0.7471878 0.8196550 0.8854731 95s [428] 0.0000000 95s 95s [1] 40.01633 95s [1] 2773.961 95s [1] 2773.961 95s Dose Response Model 95s 95s Model: linlog 95s Fit-type: normal 95s 95s Residuals: 95s Min 1Q Median 3Q Max 95s -17.993 -3.920 -0.142 4.548 17.772 95s 95s Coefficients with approx. stand. error: 95s Estimate Std. Error 95s e0 -12.53812 2.7627 95s delta 2.19176 0.4045 95s age -0.00815 0.0103 95s centergreen -0.11764 0.9231 95s centerred -1.68381 0.9385 95s centersilver -0.40779 0.9137 95s centeryellow -0.83235 0.9332 95s 95s Residual standard error: 6.12 95s Degrees of freedom: 421 95s 95s Call: 95s lm(formula = y ~ log(x + off) + age + center, data = datset) 95s 95s Residuals: 95s Min 1Q Median 3Q Max 95s -17.7720 -4.5476 0.1417 3.9205 17.9926 95s 95s Coefficients: 95s Estimate Std. Error t value Pr(>|t|) 95s (Intercept) -12.538125 2.762741 -4.538 7.41e-06 *** 95s log(x + off) 2.191761 0.404501 5.418 1.01e-07 *** 95s age -0.008153 0.010337 -0.789 0.4308 95s centergreen -0.117636 0.923131 -0.127 0.8987 95s centerred -1.683810 0.938487 -1.794 0.0735 . 95s centersilver -0.407788 0.913735 -0.446 0.6556 95s centeryellow -0.832351 0.933224 -0.892 0.3730 95s --- 95s Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 95s 95s Residual standard error: 6.118 on 421 degrees of freedom 95s Multiple R-squared: 0.07685, Adjusted R-squared: 0.06369 95s F-statistic: 5.841 on 6 and 421 DF, p-value: 7.284e-06 95s 95s e0 delta age centergreen 95s e0 7.632738169 -1.0659544595 -0.0077749645 -0.2388230420 95s delta -1.065954459 0.1636213662 0.0003614495 -0.0285500750 95s age -0.007774965 0.0003614495 0.0001068627 0.0002013374 95s centergreen -0.238823042 -0.0285500750 0.0002013374 0.8521701509 95s centerred -0.327169799 -0.0143714026 0.0001539174 0.4142785346 95s centersilver -0.343366284 -0.0139200933 0.0004143178 0.4148464502 95s centeryellow -0.304904773 -0.0188552161 0.0002799329 0.4153997441 95s centerred centersilver centeryellow 95s e0 -0.3271697994 -0.3433662837 -0.3049047728 95s delta -0.0143714026 -0.0139200933 -0.0188552161 95s age 0.0001539174 0.0004143178 0.0002799329 95s centergreen 0.4142785346 0.4148464502 0.4153997441 95s centerred 0.8807582409 0.4133097826 0.4135270947 95s centersilver 0.4133097826 0.8349108233 0.4142615949 95s centeryellow 0.4135270947 0.4142615949 0.8709075166 95s (Intercept) log(x + off) age centergreen 95s (Intercept) 7.632738169 -1.0659544595 -0.0077749645 -0.2388230420 95s log(x + off) -1.065954459 0.1636213662 0.0003614495 -0.0285500750 95s age -0.007774965 0.0003614495 0.0001068627 0.0002013374 95s centergreen -0.238823042 -0.0285500750 0.0002013374 0.8521701509 95s centerred -0.327169799 -0.0143714026 0.0001539174 0.4142785346 95s centersilver -0.343366284 -0.0139200933 0.0004143178 0.4148464502 95s centeryellow -0.304904773 -0.0188552161 0.0002799329 0.4153997441 95s centerred centersilver centeryellow 95s (Intercept) -0.3271697994 -0.3433662837 -0.3049047728 95s log(x + off) -0.0143714026 -0.0139200933 -0.0188552161 95s age 0.0001539174 0.0004143178 0.0002799329 95s centergreen 0.4142785346 0.4148464502 0.4153997441 95s centerred 0.8807582409 0.4133097826 0.4135270947 95s centersilver 0.4133097826 0.8349108233 0.4142615949 95s centeryellow 0.4135270947 0.4142615949 0.8709075166 95s $fit 95s [1] -3.511779 -3.480690 -3.450035 -1.567022 95s 95s $se.fit 95s [1] 1.1058048 1.1012159 1.0967017 0.8461873 95s 95s $fit 95s 1 2 3 4 95s -3.511779 -3.480690 -3.450035 -1.567022 95s 95s $se.fit 95s 1 2 3 4 95s 1.1058048 1.1012159 1.0967017 0.8461873 95s 95s $df 95s [1] 421 95s 95s $residual.scale 95s [1] 6.117927 95s 95s [1] 40.47058 95s [1] 54.33574 95s [1] 54.33574 95s Dose Response Model 95s 95s Model: quadratic 95s Fit-type: normal 95s 95s Residuals: 95s Min 1Q Median 3Q Max 95s -9.08e-01 -3.06e-01 3.08e-05 2.39e-01 7.57e-01 95s 95s Coefficients with approx. stand. error: 95s Estimate Std. Error 95s e0 -3.12e+00 9.19e-02 95s b1 -6.61e-04 1.47e-03 95s b2 5.18e-06 4.40e-06 95s 95s Residual standard error: 0.401 95s Degrees of freedom: 46 95s 95s Call: 95s lm(formula = y ~ x + I(x^2), data = datset) 95s 95s Residuals: 95s Min 1Q Median 3Q Max 95s -0.75741 -0.23947 -0.00003 0.30638 0.90831 95s 95s Coefficients: 95s Estimate Std. Error t value Pr(>|t|) 95s (Intercept) -3.118e+00 9.195e-02 -33.914 <2e-16 *** 95s x -6.612e-04 1.466e-03 -0.451 0.654 95s I(x^2) 5.175e-06 4.401e-06 1.176 0.246 95s --- 95s Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 95s 95s Residual standard error: 0.4007 on 46 degrees of freedom 95s Multiple R-squared: 0.1193, Adjusted R-squared: 0.08097 95s F-statistic: 3.115 on 2 and 46 DF, p-value: 0.05388 95s 95s e0 b1 b2 95s e0 8.454726e-03 -7.868733e-05 1.608713e-07 95s b1 -7.868733e-05 2.149290e-06 -6.145868e-09 95s b2 1.608713e-07 -6.145868e-09 1.936461e-11 95s (Intercept) x I(x^2) 95s (Intercept) 8.454726e-03 -7.868733e-05 1.608713e-07 95s x -7.868733e-05 2.149290e-06 -6.145868e-09 95s I(x^2) 1.608713e-07 -6.145868e-09 1.936461e-11 95s $fit 95s [1] 0.49280484 0.00000000 0.05861756 0.00000000 0.25773527 0.00000000 95s [7] 0.05861756 0.00000000 0.25773527 0.05861756 0.25773527 -0.01991690 95s [13] 0.05861756 -0.01991690 0.05861756 0.02376374 0.05861756 0.05861756 95s [19] 0.02376374 0.49280484 0.00000000 0.49280484 0.00000000 0.05861756 95s [25] 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.02376374 95s [31] 0.25773527 0.00000000 0.25773527 -0.01991690 0.25773527 0.00000000 95s [37] 0.00000000 0.00000000 0.25773527 0.00000000 0.25773527 -0.01991690 95s [43] 0.25773527 0.02376374 0.05861756 -0.01991690 0.00000000 0.25773527 95s [49] 0.00000000 95s 95s $se.fit 95s [1] 0.19776187 0.00000000 0.13594191 0.00000000 0.13486241 0.00000000 95s [7] 0.13594191 0.00000000 0.13486241 0.13594191 0.13486241 0.09012454 95s [13] 0.13594191 0.09012454 0.13594191 0.13105561 0.13594191 0.13594191 95s [19] 0.13105561 0.19776187 0.00000000 0.19776187 0.00000000 0.13594191 95s [25] 0.00000000 0.00000000 0.00000000 0.00000000 0.00000000 0.13105561 95s [31] 0.13486241 0.00000000 0.13486241 0.09012454 0.13486241 0.00000000 95s [37] 0.00000000 0.00000000 0.13486241 0.00000000 0.13486241 0.09012454 95s [43] 0.13486241 0.13105561 0.13594191 0.09012454 0.00000000 0.13486241 95s [49] 0.00000000 95s 95s $fit 95s [1] -3.118383 -3.124477 -3.132746 95s 95s $se.fit 95s [1] 0.09194958 0.08435629 0.08409705 95s 95s $fit 95s 1 2 3 95s -3.118383 -3.124477 -3.132746 95s 95s $se.fit 95s 1 2 3 95s 0.09194958 0.08435629 0.08409705 95s 95s $df 95s [1] 46 95s 95s $residual.scale 95s [1] 0.4007027 95s 95s [1] 508.0679 95s [1] 62.95473 95s [1] 62.95473 95s Dose Response Model 95s 95s Model: quadratic 95s Fit-type: normal 95s 95s Residuals: 95s Min 1Q Median 3Q Max 95s -0.87232 -0.24673 -0.00516 0.29930 0.65583 95s 95s Coefficients with approx. stand. error: 95s Estimate Std. Error 95s e0 -3.08e+00 1.69e-01 95s b1 -5.76e-04 1.59e-03 95s b2 4.82e-06 4.74e-06 95s age -1.60e-03 2.09e-03 95s centergreen -4.89e-03 2.03e-01 95s centerred 6.72e-02 1.75e-01 95s centersilver 7.81e-02 1.87e-01 95s centeryellow 9.70e-02 1.95e-01 95s 95s Residual standard error: 0.418 95s Degrees of freedom: 41 95s 95s Call: 95s lm(formula = y ~ x + I(x^2) + age + center, data = datset) 95s 95s Residuals: 95s Min 1Q Median 3Q Max 95s -0.65583 -0.29930 0.00516 0.24673 0.87232 95s 95s Coefficients: 95s Estimate Std. Error t value Pr(>|t|) 95s (Intercept) -3.076e+00 1.692e-01 -18.182 <2e-16 *** 95s x -5.756e-04 1.594e-03 -0.361 0.720 95s I(x^2) 4.822e-06 4.738e-06 1.018 0.315 95s age -1.604e-03 2.092e-03 -0.767 0.448 95s centergreen -4.891e-03 2.034e-01 -0.024 0.981 95s centerred 6.715e-02 1.753e-01 0.383 0.704 95s centersilver 7.814e-02 1.875e-01 0.417 0.679 95s centeryellow 9.700e-02 1.950e-01 0.497 0.622 95s --- 95s Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 95s 95s Residual standard error: 0.4185 on 41 degrees of freedom 95s Multiple R-squared: 0.1437, Adjusted R-squared: -0.002451 95s F-statistic: 0.9832 on 7 and 41 DF, p-value: 0.4566 95s 95s e0 b1 b2 age 95s e0 2.862812e-02 -7.239847e-05 1.267650e-07 -2.074072e-04 95s b1 -7.239847e-05 2.540221e-06 -7.184577e-09 5.108591e-08 95s b2 1.267650e-07 -7.184577e-09 2.245217e-11 3.521184e-11 95s age -2.074072e-04 5.108591e-08 3.521184e-11 4.376769e-06 95s centergreen -6.997613e-03 -8.024708e-05 1.931149e-07 -9.351576e-05 95s centerred -1.143502e-02 -7.161311e-06 3.686110e-08 -7.667700e-05 95s centersilver -1.190681e-02 -4.175985e-05 1.275528e-07 -4.035812e-05 95s centeryellow -1.311971e-02 -2.255991e-05 1.246186e-08 1.810824e-05 95s centergreen centerred centersilver centeryellow 95s e0 -6.997613e-03 -1.143502e-02 -1.190681e-02 -1.311971e-02 95s b1 -8.024708e-05 -7.161311e-06 -4.175985e-05 -2.255991e-05 95s b2 1.931149e-07 3.686110e-08 1.275528e-07 1.246186e-08 95s age -9.351576e-05 -7.667700e-05 -4.035812e-05 1.810824e-05 95s centergreen 4.137795e-02 1.614879e-02 1.658732e-02 1.565529e-02 95s centerred 1.614879e-02 3.073191e-02 1.550655e-02 1.384931e-02 95s centersilver 1.658732e-02 1.550655e-02 3.515550e-02 1.452661e-02 95s centeryellow 1.565529e-02 1.384931e-02 1.452661e-02 3.804408e-02 95s (Intercept) x I(x^2) age 95s (Intercept) 2.862812e-02 -7.239847e-05 1.267650e-07 -2.074072e-04 95s x -7.239847e-05 2.540221e-06 -7.184577e-09 5.108591e-08 95s I(x^2) 1.267650e-07 -7.184577e-09 2.245217e-11 3.521184e-11 95s age -2.074072e-04 5.108591e-08 3.521184e-11 4.376769e-06 95s centergreen -6.997613e-03 -8.024708e-05 1.931149e-07 -9.351576e-05 95s centerred -1.143502e-02 -7.161311e-06 3.686110e-08 -7.667700e-05 95s centersilver -1.190681e-02 -4.175985e-05 1.275528e-07 -4.035812e-05 95s centeryellow -1.311971e-02 -2.255991e-05 1.246186e-08 1.810824e-05 95s centergreen centerred centersilver centeryellow 95s (Intercept) -6.997613e-03 -1.143502e-02 -1.190681e-02 -1.311971e-02 95s x -8.024708e-05 -7.161311e-06 -4.175985e-05 -2.255991e-05 95s I(x^2) 1.931149e-07 3.686110e-08 1.275528e-07 1.246186e-08 95s age -9.351576e-05 -7.667700e-05 -4.035812e-05 1.810824e-05 95s centergreen 4.137795e-02 1.614879e-02 1.658732e-02 1.565529e-02 95s centerred 1.614879e-02 3.073191e-02 1.550655e-02 1.384931e-02 95s centersilver 1.658732e-02 1.550655e-02 3.515550e-02 1.452661e-02 95s centeryellow 1.565529e-02 1.384931e-02 1.452661e-02 3.804408e-02 95s $fit 95s [1] -3.124527 -3.129801 -3.133870 95s 95s $se.fit 95s [1] 0.1418548 0.1377349 0.1475950 95s 95s $fit 95s 1 2 3 95s -3.124527 -3.129801 -3.133870 95s 95s $se.fit 95s 1 2 3 95s 0.1418548 0.1377349 0.1475950 95s 95s $df 95s [1] 41 95s 95s $residual.scale 95s [1] 0.418494 95s 95s [1] 215.5724 95s [1] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [38] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [75] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [112] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [149] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [186] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [223] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [260] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [297] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 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95s [112] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [149] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [186] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [223] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [260] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [297] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [334] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [1] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [38] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [75] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [112] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [149] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [186] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [223] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [260] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [297] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [334] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [1] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [38] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [75] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [112] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [149] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [186] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [223] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [260] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [297] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [334] 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 95s [1] 0 0 0 0 0 95s [1] 0 0 0 0 0 95s Warning message: 95s In checkAnalyArgs(dose, resp, data, S, type, addCovars, placAdj, : 95s mns is not a numeric but a array, converting with as.numeric() 95s Warning message: 95s In checkAnalyArgs(dose, resp, data, S, type, addCovars, placAdj, : 95s mns is not a numeric but a array, converting with as.numeric() 95s Warning message: 95s In checkAnalyArgs(dose, resp, data, S, type, addCovars, placAdj, : 95s mns is not a numeric but a array, converting with as.numeric() 95s e0 delta 95s 0.47569910 0.02447331 95s e0 delta 95s 0.47569910 0.02447331 95s Warning message: 95s In checkAnalyArgs(dose, resp, data, S, type, addCovars, placAdj, : 95s mns is not a numeric but a array, converting with as.numeric() 95s testsFitting.R passed 95s Loading required package: DoseFinding 97s testsMCPMod.R passed 97s Loading required package: DoseFinding 98s Loading required package: multcomp 98s Loading required package: mvtnorm 98s Loading required package: survival 99s Loading required package: TH.data 99s Loading required package: MASS 99s 99s Attaching package: ‘TH.data’ 99s 99s The following object is masked from ‘package:MASS’: 99s 99s geyser 99s 99s Warning message: 99s package ‘MASS’ was built under R version 4.4.3 99s 99s Simultaneous Tests for General Linear Hypotheses 99s 99s Multiple Comparisons of Means: User-defined Contrasts 99s 99s 99s Fit: lm(formula = y ~ x + cov1 + cov2, data = dd2) 99s 99s Linear Hypotheses: 99s Estimate Std. Error t value Pr(>t) 99s linear <= 0 0.07260 0.05755 1.262 0.1756 99s betaMod <= 0 0.12179 0.05559 2.191 0.0287 * 99s sigEmax <= 0 0.08677 0.05648 1.536 0.1114 99s --- 99s Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 99s (Adjusted p values reported -- single-step method) 99s 99s Multiple Contrast Test 99s 99s Contrasts: 99s linear betaMod sigEmax 99s 0 -0.472 -0.492 -0.349 99s 172 -0.391 -0.345 -0.489 99s 285 -0.132 0.032 -0.240 99s 516 0.262 0.799 0.503 99s 761 0.733 0.007 0.574 99s 99s Contrast Correlation: 99s linear betaMod sigEmax 99s linear 1.000 0.645 0.942 99s betaMod 0.645 1.000 0.741 99s sigEmax 0.942 0.741 1.000 99s 99s Multiple Contrast Test: 99s t-Stat adj-p 99s betaMod 2.191 0.0287 99s sigEmax 1.536 0.1112 99s linear 1.262 0.1757 99s 99s Simultaneous Tests for General Linear Hypotheses 99s 99s Multiple Comparisons of Means: User-defined Contrasts 99s 99s 99s Fit: lm(formula = y ~ x, data = dd2) 99s 99s Linear Hypotheses: 99s Estimate Std. Error t value Pr(>t) 99s linear <= 0 0.07985 0.05691 1.403 0.1404 99s betaMod <= 0 0.11839 0.05507 2.150 0.0314 * 99s sigEmax <= 0 0.09407 0.05594 1.682 0.0853 . 99s --- 99s Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 99s (Adjusted p values reported -- single-step method) 99s 99s Multiple Contrast Test 99s 99s Contrasts: 99s linear betaMod sigEmax 99s 0 -0.472 -0.487 -0.347 99s 172 -0.389 -0.348 -0.490 99s 285 -0.132 0.030 -0.239 99s 516 0.255 0.800 0.500 99s 761 0.738 0.005 0.576 99s 99s Contrast Correlation: 99s linear betaMod sigEmax 99s linear 1.000 0.642 0.941 99s betaMod 0.642 1.000 0.740 99s sigEmax 0.941 0.740 1.000 99s 99s Multiple Contrast Test: 99s t-Stat adj-p 99s betaMod 2.150 0.0317 99s sigEmax 1.682 0.0852 99s linear 1.403 0.1403 99s 99s Simultaneous Tests for General Linear Hypotheses 99s 99s Multiple Comparisons of Means: User-defined Contrasts 99s 99s 99s Fit: lm(formula = y ~ x + cov1 + cov2, data = dd2) 99s 99s Linear Hypotheses: 99s Estimate Std. Error t value Pr(>t) 99s linlog <= 0 0.09114 0.05971 1.526 0.1510 99s logistic1 <= 0 0.10293 0.05761 1.787 0.0940 . 99s logistic2 <= 0 0.09583 0.05707 1.679 0.1154 99s exponential <= 0 0.02544 0.05514 0.461 0.5623 99s quadratic <= 0 0.11676 0.05980 1.952 0.0674 . 99s --- 99s Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 99s (Adjusted p values reported -- single-step method) 99s 99s Multiple Contrast Test 99s 99s Contrasts: 99s linlog logistic1 logistic2 exponential quadratic 99s 0 -0.624 -0.448 -0.457 -0.268 -0.665 99s 172 -0.309 -0.590 -0.475 -0.347 -0.055 99s 285 -0.049 0.101 -0.118 -0.191 0.199 99s 516 0.366 0.500 0.499 -0.069 0.696 99s 761 0.616 0.437 0.550 0.875 -0.174 99s 99s Contrast Correlation: 99s linlog logistic1 logistic2 exponential quadratic 99s linlog 1.000 0.902 0.955 0.799 0.651 99s logistic1 0.902 1.000 0.949 0.671 0.660 99s logistic2 0.955 0.949 1.000 0.792 0.586 99s exponential 0.799 0.671 0.792 1.000 0.063 99s quadratic 0.651 0.660 0.586 0.063 1.000 99s 99s Multiple Contrast Test: 99s t-Stat adj-p 99s quadratic 1.952 0.0675 99s logistic1 1.787 0.0941 99s logistic2 1.679 0.1154 99s linlog 1.526 0.1506 99s exponential 0.461 0.5625 99s 99s Simultaneous Tests for General Linear Hypotheses 99s 99s Multiple Comparisons of Means: User-defined Contrasts 99s 99s 99s Fit: lm(formula = y ~ x, data = dd2) 99s 99s Linear Hypotheses: 99s Estimate Std. Error t value Pr(>t) 99s linlog <= 0 0.09484 0.05913 1.604 0.1320 99s logistic1 <= 0 0.10608 0.05706 1.859 0.0817 . 99s logistic2 <= 0 0.10119 0.05654 1.790 0.0928 . 99s exponential <= 0 0.03666 0.05440 0.674 0.4665 99s quadratic <= 0 0.10792 0.05938 1.817 0.0885 . 99s --- 99s Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 99s (Adjusted p values reported -- single-step method) 99s 99s Multiple Contrast Test 99s 99s Contrasts: 99s linlog logistic1 logistic2 exponential quadratic 99s 0 -0.623 -0.445 -0.455 -0.270 -0.664 99s 172 -0.307 -0.592 -0.476 -0.342 -0.056 99s 285 -0.050 0.101 -0.118 -0.189 0.197 99s 516 0.358 0.497 0.496 -0.076 0.698 99s 761 0.622 0.440 0.554 0.877 -0.175 99s 99s Contrast Correlation: 99s linlog logistic1 logistic2 exponential quadratic 99s linlog 1.000 0.901 0.955 0.800 0.648 99s logistic1 0.901 1.000 0.949 0.670 0.658 99s logistic2 0.955 0.949 1.000 0.792 0.584 99s exponential 0.800 0.670 0.792 1.000 0.062 99s quadratic 0.648 0.658 0.584 0.062 1.000 99s 99s Multiple Contrast Test: 99s t-Stat adj-p 99s logistic1 1.859 0.0816 99s quadratic 1.817 0.0887 99s logistic2 1.790 0.0933 99s linlog 1.604 0.1316 99s exponential 0.674 0.4667 99s 99s Simultaneous Tests for General Linear Hypotheses 99s 99s Multiple Comparisons of Means: User-defined Contrasts 99s 99s 99s Fit: lm(formula = y ~ x, data = dd2) 99s 99s Linear Hypotheses: 99s Estimate Std. Error t value Pr(>t) 99s linlog <= 0 -0.2995 1.0212 -0.293 0.821 99s logistic1 <= 0 -0.1795 0.9837 -0.182 0.785 99s logistic2 <= 0 -0.1401 0.9877 -0.142 0.771 99s exponential <= 0 -0.2892 0.9568 -0.302 0.823 99s quadratic <= 0 -0.1973 1.2830 -0.154 0.776 99s (Adjusted p values reported -- single-step method) 99s 99s Multiple Contrast Test 99s 99s Contrasts: 99s linlog logistic1 logistic2 exponential quadratic 99s 0 -0.464 -0.268 -0.289 -0.207 -0.751 99s 124 -0.436 -0.627 -0.556 -0.450 -0.241 99s 272 0.013 -0.006 -0.083 -0.187 0.476 99s 560 0.127 0.196 0.172 -0.004 0.353 99s 865 0.761 0.705 0.755 0.848 0.164 99s 99s Contrast Correlation: 99s linlog logistic1 logistic2 exponential quadratic 99s linlog 1.000 0.950 0.963 0.890 0.665 99s logistic1 0.950 1.000 0.992 0.879 0.591 99s logistic2 0.963 0.992 1.000 0.922 0.542 99s exponential 0.890 0.879 0.922 1.000 0.252 99s quadratic 0.665 0.591 0.542 0.252 1.000 99s 99s Multiple Contrast Test: 99s t-Stat adj-p 99s logistic2 -0.142 0.771 99s quadratic -0.154 0.776 99s logistic1 -0.182 0.785 99s linlog -0.293 0.821 99s exponential -0.302 0.823 99s 99s Simultaneous Tests for General Linear Hypotheses 99s 99s Multiple Comparisons of Means: User-defined Contrasts 99s 99s 99s Fit: glm(formula = y ~ x - 1, family = binomial, data = dd2, weights = n) 99s 99s Linear Hypotheses: 99s Estimate Std. Error z value Pr(>z) 99s linear <= 0 0.19645 0.33561 0.585 0.395 99s betaMod <= 0 0.03813 0.31565 0.121 0.587 99s sigEmax <= 0 0.30472 0.34592 0.881 0.283 99s (Adjusted p values reported -- single-step method) 99s 99s Multiple Contrast Test 99s 99s Contrasts: 99s linear betaMod sigEmax 99s 0 -0.794 -0.793 -0.774 99s 190 -0.064 -0.022 -0.192 99s 344 0.197 0.577 0.317 99s 404 0.098 0.190 0.163 99s 616 0.563 0.048 0.487 99s 99s Contrast Correlation: 99s linear betaMod sigEmax 99s linear 1.000 0.723 0.962 99s betaMod 0.723 1.000 0.793 99s sigEmax 0.962 0.793 1.000 99s 99s Multiple Contrast Test: 99s t-Stat adj-p 99s sigEmax 0.881 0.283 99s linear 0.585 0.395 99s betaMod 0.121 0.587 99s 99s Simultaneous Tests for General Linear Hypotheses 99s 99s Multiple Comparisons of Means: User-defined Contrasts 99s 99s 99s Fit: glm(formula = y ~ x - 1, family = binomial, data = dd2, weights = n) 99s 99s Linear Hypotheses: 99s Estimate Std. Error z value Pr(>z) 99s linear <= 0 0.2547 0.1877 1.357 0.1500 99s betaMod <= 0 0.2367 0.2371 0.999 0.2555 99s sigEmax <= 0 0.3698 0.1889 1.958 0.0476 * 99s --- 99s Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1 99s (Adjusted p values reported -- single-step method) 99s 99s Multiple Contrast Test 99s 99s Contrasts: 99s linear betaMod sigEmax 99s 0 0.418 0.634 0.310 99s 68.5 0.114 0.150 0.139 99s 85.9 0.387 0.362 0.551 99s 166 0.027 -0.572 -0.033 99s 197 -0.015 -0.158 -0.054 99s 278 -0.129 -0.264 -0.172 99s 332 -0.803 -0.152 -0.740 99s 99s Contrast Correlation: 99s linear betaMod sigEmax 99s linear 1.000 0.635 0.967 99s betaMod 0.635 1.000 0.677 99s sigEmax 0.967 0.677 1.000 99s 99s Multiple Contrast Test: 99s t-Stat adj-p 99s sigEmax 1.958 0.0477 99s linear 1.357 0.1501 99s betaMod 0.999 0.2556 99s 99s Simultaneous Tests for General Linear Hypotheses 99s 99s Multiple Comparisons of Means: User-defined Contrasts 99s 99s 99s Fit: glm(formula = y ~ x - 1, family = binomial, data = dd2, weights = n) 99s 99s Linear Hypotheses: 99s Estimate Std. Error z value Pr(>z) 99s linear <= 0 0.3391 0.3218 1.054 0.226 99s betaMod <= 0 0.3556 0.3124 1.138 0.201 99s sigEmax <= 0 0.2935 0.3497 0.839 0.299 99s (Adjusted p values reported -- single-step method) 99s 99s Multiple Contrast Test 99s 99s Contrasts: 99s linear betaMod sigEmax 99s 0 -0.721 -0.796 -0.547 99s 79.1 -0.129 -0.102 -0.312 99s 117 0.005 0.106 -0.137 99s 208 0.191 0.519 0.288 99s 398 0.654 0.274 0.708 99s 99s Contrast Correlation: 99s linear betaMod sigEmax 99s linear 1.000 0.785 0.954 99s betaMod 0.785 1.000 0.742 99s sigEmax 0.954 0.742 1.000 99s 99s Multiple Contrast Test: 99s t-Stat adj-p 99s betaMod 1.138 0.201 99s linear 1.054 0.226 99s sigEmax 0.839 0.299 99s Warning message: 99s In MCTpval(contMat, corMat, df, tStat, alternative, mvtcontrol) : 99s Warning from mvtnorm::pmvt: univariate: using pnorm. 99s 99s Simultaneous Tests for General Linear Hypotheses 99s 99s Multiple Comparisons of Means: User-defined Contrasts 99s 99s 99s Fit: glm(formula = y ~ x - 1, family = binomial, data = dd2, weights = n) 99s 99s Linear Hypotheses: 99s Estimate Std. Error z value Pr(>z) 99s linear <= 0 0.3391 0.3218 1.054 0.146 99s (Adjusted p values reported -- single-step method) 99s 99s Multiple Contrast Test 99s 99s Contrasts: 99s linear 99s 0 -0.721 99s 79.1 -0.129 99s 117 0.005 99s 208 0.191 99s 398 0.654 99s 99s Contrast Correlation: 99s linear 99s linear 1 99s 99s Multiple Contrast Test: 99s t-Stat adj-p 99s linear 1.054 0.146 99s Message: Need bounds in "bnds" for nonlinear models, using default bounds from "defBnds". 99s Dose Response Model 99s 99s Model: sigEmax 99s Fit-type: general 99s 99s Coefficients dose-response model 99s eMax ed50 h 99s 0.4714 0.4880 0.5000 99s 99s Fitted to: 99s 1 2 3 4 99s 0.2846 0.2965 0.3502 0.3480 99s 99s Generalized residual sum of squares: 0.07825 99s Multiple Contrast Test 99s 99s Contrasts: 99s emax linear logistic linInt 99s 1 0.462 -0.429 0.511 -0.672 99s 2 0.505 0.002 0.507 0.437 99s 3 0.504 0.400 0.485 0.418 99s 4 0.527 0.810 0.497 0.428 99s 99s Contrast Correlation: 99s emax linear logistic linInt 99s emax 1.000 0.715 1.000 0.617 99s linear 0.715 1.000 0.698 0.863 99s logistic 1.000 0.698 1.000 0.598 99s linInt 0.617 0.863 0.598 1.000 99s 99s Multiple Contrast Test: 99s t-Stat adj-p 99s emax 3.178 0.00193 99s logistic 3.164 0.00194 99s linear 2.640 0.00968 99s linInt 2.247 0.02721 99s Dose Response Model 99s 99s Model: sigEmax 99s Fit-type: general 99s 99s Coefficients dose-response model 99s eMax ed50 h 99s 0.4714 0.4880 0.5000 99s 99s Fitted to: 99s 3 4 1 2 99s 0.3502 0.3480 0.2846 0.2965 99s 99s Generalized residual sum of squares: 0.07825 99s Message: Need bounds in "bnds" for nonlinear models, using default bounds from "defBnds". 99s Multiple Contrast Test 99s 99s Contrasts: 99s emax linear logistic linInt 99s 1 0.462 -0.429 0.511 -0.672 99s 2 0.505 0.002 0.507 0.437 99s 3 0.504 0.400 0.485 0.418 99s 4 0.527 0.810 0.497 0.428 99s 99s Contrast Correlation: 99s emax linear logistic linInt 99s emax 1.000 0.715 1.000 0.617 99s linear 0.715 1.000 0.698 0.863 99s logistic 1.000 0.698 1.000 0.598 99s linInt 0.617 0.863 0.598 1.000 99s 99s Multiple Contrast Test: 99s t-Stat adj-p 99s emax 3.178 0.00213 99s logistic 3.164 0.00174 99s linear 2.640 0.00941 99s linInt 2.247 0.02663 99s Message: Need bounds in "bnds" for nonlinear models, using default bounds from "defBnds". 99s Message: Need bounds in "bnds" for nonlinear models, using default bounds from "defBnds". 99s Dose Response Model 99s 99s Model: sigEmax 99s Fit-type: general 99s 99s Coefficients dose-response model 99s e0 eMax ed50 h 99s 0.2171 0.4714 0.4860 0.5000 99s 99s Fitted to: 99s 0 1 2 3 4 99s 0.2169 0.5016 0.5138 0.5677 0.5648 99s 99s Generalized residual sum of squares: 0.07892 99s Multiple Contrast Test 99s 99s Contrasts: 99s emax linear logistic linInt 99s 0 -0.894 -0.617 -0.894 -0.522 99s 1 0.207 -0.338 0.228 -0.573 99s 2 0.226 0.002 0.227 0.373 99s 3 0.227 0.315 0.218 0.358 99s 4 0.235 0.637 0.221 0.363 99s 99s Contrast Correlation: 99s emax linear logistic linInt 99s emax 1.000 0.715 1.000 0.618 99s linear 0.715 1.000 0.698 0.863 99s logistic 1.000 0.698 1.000 0.599 99s linInt 0.618 0.863 0.599 1.000 99s 99s Multiple Contrast Test: 99s t-Stat adj-p 99s emax 3.186 0.00184 99s logistic 3.172 0.00177 99s linear 2.645 0.00956 99s linInt 2.254 0.02649 99s Dose Response Model 99s 99s Model: sigEmax 99s Fit-type: general 99s 99s Coefficients dose-response model 99s e0 eMax ed50 h 99s 0.2171 0.4714 0.4860 0.5000 99s 99s Fitted to: 99s 2 3 0 1 4 99s 0.5138 0.5677 0.2169 0.5016 0.5648 99s 99s Generalized residual sum of squares: 0.07892 99s Multiple Contrast Test 99s 99s Contrasts: 99s emax linear logistic linInt 99s 0 -0.894 -0.617 -0.894 -0.522 99s 1 0.207 -0.338 0.228 -0.573 99s 2 0.226 0.002 0.227 0.373 99s 3 0.227 0.315 0.218 0.358 99s 4 0.235 0.637 0.221 0.363 99s 99s Contrast Correlation: 99s emax linear logistic linInt 99s emax 1.000 0.715 1.000 0.618 99s linear 0.715 1.000 0.698 0.863 99s logistic 1.000 0.698 1.000 0.599 99s linInt 0.618 0.863 0.599 1.000 99s 99s Multiple Contrast Test: 99s t-Stat adj-p 99s emax 3.186 0.00163 99s logistic 3.172 0.00192 99s linear 2.645 0.00981 99s linInt 2.254 0.02699 99s [1] TRUE 99s Warning messages: 99s 1: In MCTpval(contMat, corMat, df, tStat, alternative, mvtcontrol) : 99s Warning from mvtnorm::pmvt: Covariance matrix not positive semidefinite. 99s 2: In MCTpval(contMat, corMat, df, tStat, alternative, mvtcontrol) : 99s Setting calculated p-value to NA 100s testsMCT.R passed 100s Loading required package: DoseFinding 100s Loading required package: quadprog 100s Loading required package: Rsolnp 100s testsoptContr.R passed 100s testsplotDRMod.R consists only from comments and returns non-zero exit value ... ignored 101s testssampSize.R passed 101s Loading required package: DoseFinding 102s [1] 0.3076509 102s [1] 0.6153019 102s [1] 0.9229528 102s [1] 2.673503 102s [1] 0.7028559 102s [1] 2.064397 102s [1] NA 102s testssamplMod.R passed 104s Running simulations 104s Scenario 1/5 104s | | | 0% | |* | 1% | |* | 2% | |** | 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|********************************************************************* | 98% | |********************************************************************* | 99% | |**********************************************************************| 100% 106s [ FAIL 0 | WARN 0 | SKIP 1 | PASS 32 ] 106s 106s ══ Skipped tests (1) ═══════════════════════════════════════════════════════════ 106s • On CRAN (1): 'test-planMod.R:27:3' 106s 106s [ FAIL 0 | WARN 0 | SKIP 1 | PASS 32 ] 106s testthat.R passed 107s autopkgtest [05:01:21]: test run-unit-test: -----------------------] 107s run-unit-test PASS 107s autopkgtest [05:01:21]: test run-unit-test: - - - - - - - - - - results - - - - - - - - - - 107s autopkgtest [05:01:21]: test pkg-r-autopkgtest: preparing testbed 107s Reading package lists... 107s Building dependency tree... 107s Reading state information... 108s Starting pkgProblemResolver with broken count: 0 108s Starting 2 pkgProblemResolver with broken count: 0 108s Done 108s The following NEW packages will be installed: 108s build-essential cpp cpp-14 cpp-14-x86-64-linux-gnu cpp-x86-64-linux-gnu 108s dctrl-tools g++ g++-14 g++-14-x86-64-linux-gnu g++-x86-64-linux-gnu gcc 108s gcc-14 gcc-14-x86-64-linux-gnu gcc-x86-64-linux-gnu gfortran gfortran-14 108s gfortran-14-x86-64-linux-gnu gfortran-x86-64-linux-gnu icu-devtools libasan8 108s libblas-dev libbz2-dev libcc1-0 libdeflate-dev libgcc-14-dev 108s libgfortran-14-dev libhwasan0 libicu-dev libisl23 libitm1 libjpeg-dev 108s libjpeg-turbo8-dev libjpeg8-dev liblapack-dev liblsan0 liblzma-dev libmpc3 108s libncurses-dev libpcre2-16-0 libpcre2-32-0 libpcre2-dev libpcre2-posix3 108s libpkgconf3 libpng-dev libquadmath0 libreadline-dev libstdc++-14-dev 108s libtirpc-dev libtsan2 libubsan1 pkg-r-autopkgtest pkgconf pkgconf-bin 108s r-base-dev zlib1g-dev 108s 0 upgraded, 55 newly installed, 0 to remove and 0 not upgraded. 108s Need to get 103 MB of archives. 108s After this operation, 363 MB of additional disk space will be used. 108s Get:1 http://ftpmaster.internal/ubuntu plucky/main amd64 libisl23 amd64 0.27-1 [685 kB] 108s Get:2 http://ftpmaster.internal/ubuntu plucky/main amd64 libmpc3 amd64 1.3.1-1build2 [55.3 kB] 108s Get:3 http://ftpmaster.internal/ubuntu plucky/main amd64 cpp-14-x86-64-linux-gnu amd64 14.2.0-17ubuntu3 [11.9 MB] 109s Get:4 http://ftpmaster.internal/ubuntu plucky/main amd64 cpp-14 amd64 14.2.0-17ubuntu3 [1030 B] 109s Get:5 http://ftpmaster.internal/ubuntu plucky/main amd64 cpp-x86-64-linux-gnu amd64 4:14.2.0-1ubuntu1 [5586 B] 109s Get:6 http://ftpmaster.internal/ubuntu plucky/main amd64 cpp amd64 4:14.2.0-1ubuntu1 [22.4 kB] 109s Get:7 http://ftpmaster.internal/ubuntu plucky/main amd64 libcc1-0 amd64 15-20250213-1ubuntu1 [47.0 kB] 109s Get:8 http://ftpmaster.internal/ubuntu plucky/main amd64 libitm1 amd64 15-20250213-1ubuntu1 [28.5 kB] 109s Get:9 http://ftpmaster.internal/ubuntu plucky/main amd64 libasan8 amd64 15-20250213-1ubuntu1 [3059 kB] 109s Get:10 http://ftpmaster.internal/ubuntu plucky/main amd64 liblsan0 amd64 15-20250213-1ubuntu1 [1356 kB] 109s Get:11 http://ftpmaster.internal/ubuntu plucky/main amd64 libtsan2 amd64 15-20250213-1ubuntu1 [2757 kB] 109s Get:12 http://ftpmaster.internal/ubuntu plucky/main amd64 libubsan1 amd64 15-20250213-1ubuntu1 [1206 kB] 109s Get:13 http://ftpmaster.internal/ubuntu plucky/main amd64 libhwasan0 amd64 15-20250213-1ubuntu1 [1678 kB] 109s Get:14 http://ftpmaster.internal/ubuntu plucky/main amd64 libquadmath0 amd64 15-20250213-1ubuntu1 [152 kB] 109s Get:15 http://ftpmaster.internal/ubuntu plucky/main amd64 libgcc-14-dev amd64 14.2.0-17ubuntu3 [2816 kB] 109s Get:16 http://ftpmaster.internal/ubuntu plucky/main amd64 gcc-14-x86-64-linux-gnu amd64 14.2.0-17ubuntu3 [23.3 MB] 109s Get:17 http://ftpmaster.internal/ubuntu plucky/main amd64 gcc-14 amd64 14.2.0-17ubuntu3 [536 kB] 109s Get:18 http://ftpmaster.internal/ubuntu plucky/main amd64 gcc-x86-64-linux-gnu amd64 4:14.2.0-1ubuntu1 [1208 B] 109s Get:19 http://ftpmaster.internal/ubuntu plucky/main amd64 gcc amd64 4:14.2.0-1ubuntu1 [5004 B] 109s Get:20 http://ftpmaster.internal/ubuntu plucky/main amd64 libstdc++-14-dev amd64 14.2.0-17ubuntu3 [2486 kB] 109s Get:21 http://ftpmaster.internal/ubuntu plucky/main amd64 g++-14-x86-64-linux-gnu amd64 14.2.0-17ubuntu3 [13.4 MB] 109s Get:22 http://ftpmaster.internal/ubuntu plucky/main amd64 g++-14 amd64 14.2.0-17ubuntu3 [21.8 kB] 109s Get:23 http://ftpmaster.internal/ubuntu plucky/main amd64 g++-x86-64-linux-gnu amd64 4:14.2.0-1ubuntu1 [968 B] 109s Get:24 http://ftpmaster.internal/ubuntu plucky/main amd64 g++ amd64 4:14.2.0-1ubuntu1 [1100 B] 109s Get:25 http://ftpmaster.internal/ubuntu plucky/main amd64 build-essential amd64 12.10ubuntu1 [4928 B] 109s Get:26 http://ftpmaster.internal/ubuntu plucky/main amd64 dctrl-tools amd64 2.24-3build3 [106 kB] 109s Get:27 http://ftpmaster.internal/ubuntu plucky/main amd64 libgfortran-14-dev amd64 14.2.0-17ubuntu3 [966 kB] 109s Get:28 http://ftpmaster.internal/ubuntu plucky/main amd64 gfortran-14-x86-64-linux-gnu amd64 14.2.0-17ubuntu3 [12.6 MB] 109s Get:29 http://ftpmaster.internal/ubuntu plucky/main amd64 gfortran-14 amd64 14.2.0-17ubuntu3 [13.6 kB] 109s Get:30 http://ftpmaster.internal/ubuntu plucky/main amd64 gfortran-x86-64-linux-gnu amd64 4:14.2.0-1ubuntu1 [1022 B] 109s Get:31 http://ftpmaster.internal/ubuntu plucky/main amd64 gfortran amd64 4:14.2.0-1ubuntu1 [1174 B] 109s Get:32 http://ftpmaster.internal/ubuntu plucky/main amd64 icu-devtools amd64 76.1-1ubuntu2 [237 kB] 109s Get:33 http://ftpmaster.internal/ubuntu plucky/main amd64 libblas-dev amd64 3.12.1-2 [338 kB] 109s Get:34 http://ftpmaster.internal/ubuntu plucky/main amd64 libbz2-dev amd64 1.0.8-6 [33.8 kB] 109s Get:35 http://ftpmaster.internal/ubuntu plucky/main amd64 libdeflate-dev amd64 1.23-1 [71.7 kB] 109s Get:36 http://ftpmaster.internal/ubuntu plucky/main amd64 libicu-dev amd64 76.1-1ubuntu2 [12.6 MB] 109s Get:37 http://ftpmaster.internal/ubuntu plucky/main amd64 libjpeg-turbo8-dev amd64 2.1.5-3ubuntu2 [324 kB] 109s Get:38 http://ftpmaster.internal/ubuntu plucky/main amd64 libjpeg8-dev amd64 8c-2ubuntu11 [1484 B] 109s Get:39 http://ftpmaster.internal/ubuntu plucky/main amd64 libjpeg-dev amd64 8c-2ubuntu11 [1482 B] 109s Get:40 http://ftpmaster.internal/ubuntu plucky/main amd64 liblapack-dev amd64 3.12.1-2 [6489 kB] 109s Get:41 http://ftpmaster.internal/ubuntu plucky/main amd64 libncurses-dev amd64 6.5+20250216-1 [424 kB] 109s Get:42 http://ftpmaster.internal/ubuntu plucky/main amd64 libpcre2-16-0 amd64 10.45-1 [268 kB] 109s Get:43 http://ftpmaster.internal/ubuntu plucky/main amd64 libpcre2-32-0 amd64 10.45-1 [251 kB] 109s Get:44 http://ftpmaster.internal/ubuntu plucky/main amd64 libpcre2-posix3 amd64 10.45-1 [7204 B] 109s Get:45 http://ftpmaster.internal/ubuntu plucky/main amd64 libpcre2-dev amd64 10.45-1 [908 kB] 109s Get:46 http://ftpmaster.internal/ubuntu plucky/main amd64 libpkgconf3 amd64 1.8.1-4 [32.3 kB] 109s Get:47 http://ftpmaster.internal/ubuntu plucky/main amd64 zlib1g-dev amd64 1:1.3.dfsg+really1.3.1-1ubuntu1 [895 kB] 109s Get:48 http://ftpmaster.internal/ubuntu plucky/main amd64 libpng-dev amd64 1.6.47-1 [298 kB] 110s Get:49 http://ftpmaster.internal/ubuntu plucky/main amd64 libreadline-dev amd64 8.2-6 [184 kB] 110s Get:50 http://ftpmaster.internal/ubuntu plucky/main amd64 liblzma-dev amd64 5.6.3-1 [189 kB] 110s Get:51 http://ftpmaster.internal/ubuntu plucky/main amd64 pkgconf-bin amd64 1.8.1-4 [21.6 kB] 110s Get:52 http://ftpmaster.internal/ubuntu plucky/main amd64 pkgconf amd64 1.8.1-4 [16.8 kB] 110s Get:53 http://ftpmaster.internal/ubuntu plucky/main amd64 libtirpc-dev amd64 1.3.4+ds-1.3 [193 kB] 110s Get:54 http://ftpmaster.internal/ubuntu plucky/universe amd64 r-base-dev all 4.4.2-1build1 [4342 B] 110s Get:55 http://ftpmaster.internal/ubuntu plucky/universe amd64 pkg-r-autopkgtest all 20231212ubuntu1 [6448 B] 110s Fetched 103 MB in 1s (89.1 MB/s) 110s Selecting previously unselected package libisl23:amd64. 110s (Reading database ... (Reading database ... 5% (Reading database ... 10% (Reading database ... 15% (Reading database ... 20% (Reading database ... 25% (Reading database ... 30% (Reading database ... 35% (Reading database ... 40% (Reading database ... 45% (Reading database ... 50% (Reading database ... 55% (Reading database ... 60% (Reading database ... 65% (Reading database ... 70% (Reading database ... 75% (Reading database ... 80% (Reading database ... 85% (Reading database ... 90% (Reading database ... 95% (Reading database ... 100% (Reading database ... 126833 files and directories currently installed.) 110s Preparing to unpack .../00-libisl23_0.27-1_amd64.deb ... 110s Unpacking libisl23:amd64 (0.27-1) ... 110s Selecting previously unselected package libmpc3:amd64. 110s Preparing to unpack .../01-libmpc3_1.3.1-1build2_amd64.deb ... 110s Unpacking libmpc3:amd64 (1.3.1-1build2) ... 110s Selecting previously unselected package cpp-14-x86-64-linux-gnu. 110s Preparing to unpack .../02-cpp-14-x86-64-linux-gnu_14.2.0-17ubuntu3_amd64.deb ... 110s Unpacking cpp-14-x86-64-linux-gnu (14.2.0-17ubuntu3) ... 110s Selecting previously unselected package cpp-14. 110s Preparing to unpack .../03-cpp-14_14.2.0-17ubuntu3_amd64.deb ... 110s Unpacking cpp-14 (14.2.0-17ubuntu3) ... 110s Selecting previously unselected package cpp-x86-64-linux-gnu. 110s Preparing to unpack .../04-cpp-x86-64-linux-gnu_4%3a14.2.0-1ubuntu1_amd64.deb ... 110s Unpacking cpp-x86-64-linux-gnu (4:14.2.0-1ubuntu1) ... 110s Selecting previously unselected package cpp. 110s Preparing to unpack .../05-cpp_4%3a14.2.0-1ubuntu1_amd64.deb ... 110s Unpacking cpp (4:14.2.0-1ubuntu1) ... 110s Selecting previously unselected package libcc1-0:amd64. 110s Preparing to unpack .../06-libcc1-0_15-20250213-1ubuntu1_amd64.deb ... 110s Unpacking libcc1-0:amd64 (15-20250213-1ubuntu1) ... 110s Selecting previously unselected package libitm1:amd64. 110s Preparing to unpack .../07-libitm1_15-20250213-1ubuntu1_amd64.deb ... 110s Unpacking libitm1:amd64 (15-20250213-1ubuntu1) ... 111s Selecting previously unselected package libasan8:amd64. 111s Preparing to unpack .../08-libasan8_15-20250213-1ubuntu1_amd64.deb ... 111s Unpacking libasan8:amd64 (15-20250213-1ubuntu1) ... 111s Selecting previously unselected package liblsan0:amd64. 111s Preparing to unpack .../09-liblsan0_15-20250213-1ubuntu1_amd64.deb ... 111s Unpacking liblsan0:amd64 (15-20250213-1ubuntu1) ... 111s Selecting previously unselected package libtsan2:amd64. 111s Preparing to unpack .../10-libtsan2_15-20250213-1ubuntu1_amd64.deb ... 111s Unpacking libtsan2:amd64 (15-20250213-1ubuntu1) ... 111s Selecting previously unselected package libubsan1:amd64. 111s Preparing to unpack .../11-libubsan1_15-20250213-1ubuntu1_amd64.deb ... 111s Unpacking libubsan1:amd64 (15-20250213-1ubuntu1) ... 111s Selecting previously unselected package libhwasan0:amd64. 111s Preparing to unpack .../12-libhwasan0_15-20250213-1ubuntu1_amd64.deb ... 111s Unpacking libhwasan0:amd64 (15-20250213-1ubuntu1) ... 111s Selecting previously unselected package libquadmath0:amd64. 111s Preparing to unpack .../13-libquadmath0_15-20250213-1ubuntu1_amd64.deb ... 111s Unpacking libquadmath0:amd64 (15-20250213-1ubuntu1) ... 111s Selecting previously unselected package libgcc-14-dev:amd64. 111s Preparing to unpack .../14-libgcc-14-dev_14.2.0-17ubuntu3_amd64.deb ... 111s Unpacking libgcc-14-dev:amd64 (14.2.0-17ubuntu3) ... 111s Selecting previously unselected package gcc-14-x86-64-linux-gnu. 111s Preparing to unpack .../15-gcc-14-x86-64-linux-gnu_14.2.0-17ubuntu3_amd64.deb ... 111s Unpacking gcc-14-x86-64-linux-gnu (14.2.0-17ubuntu3) ... 112s Selecting previously unselected package gcc-14. 112s Preparing to unpack .../16-gcc-14_14.2.0-17ubuntu3_amd64.deb ... 112s Unpacking gcc-14 (14.2.0-17ubuntu3) ... 112s Selecting previously unselected package gcc-x86-64-linux-gnu. 112s Preparing to unpack .../17-gcc-x86-64-linux-gnu_4%3a14.2.0-1ubuntu1_amd64.deb ... 112s Unpacking gcc-x86-64-linux-gnu (4:14.2.0-1ubuntu1) ... 112s Selecting previously unselected package gcc. 112s Preparing to unpack .../18-gcc_4%3a14.2.0-1ubuntu1_amd64.deb ... 112s Unpacking gcc (4:14.2.0-1ubuntu1) ... 112s Selecting previously unselected package libstdc++-14-dev:amd64. 112s Preparing to unpack .../19-libstdc++-14-dev_14.2.0-17ubuntu3_amd64.deb ... 112s Unpacking libstdc++-14-dev:amd64 (14.2.0-17ubuntu3) ... 112s Selecting previously unselected package g++-14-x86-64-linux-gnu. 112s Preparing to unpack .../20-g++-14-x86-64-linux-gnu_14.2.0-17ubuntu3_amd64.deb ... 112s Unpacking g++-14-x86-64-linux-gnu (14.2.0-17ubuntu3) ... 112s Selecting previously unselected package g++-14. 112s Preparing to unpack .../21-g++-14_14.2.0-17ubuntu3_amd64.deb ... 112s Unpacking g++-14 (14.2.0-17ubuntu3) ... 112s Selecting previously unselected package g++-x86-64-linux-gnu. 112s Preparing to unpack .../22-g++-x86-64-linux-gnu_4%3a14.2.0-1ubuntu1_amd64.deb ... 112s Unpacking g++-x86-64-linux-gnu (4:14.2.0-1ubuntu1) ... 112s Selecting previously unselected package g++. 112s Preparing to unpack .../23-g++_4%3a14.2.0-1ubuntu1_amd64.deb ... 112s Unpacking g++ (4:14.2.0-1ubuntu1) ... 112s Selecting previously unselected package build-essential. 112s Preparing to unpack .../24-build-essential_12.10ubuntu1_amd64.deb ... 112s Unpacking build-essential (12.10ubuntu1) ... 112s Selecting previously unselected package dctrl-tools. 112s Preparing to unpack .../25-dctrl-tools_2.24-3build3_amd64.deb ... 112s Unpacking dctrl-tools (2.24-3build3) ... 112s Selecting previously unselected package libgfortran-14-dev:amd64. 112s Preparing to unpack .../26-libgfortran-14-dev_14.2.0-17ubuntu3_amd64.deb ... 112s Unpacking libgfortran-14-dev:amd64 (14.2.0-17ubuntu3) ... 112s Selecting previously unselected package gfortran-14-x86-64-linux-gnu. 112s Preparing to unpack .../27-gfortran-14-x86-64-linux-gnu_14.2.0-17ubuntu3_amd64.deb ... 112s Unpacking gfortran-14-x86-64-linux-gnu (14.2.0-17ubuntu3) ... 113s Selecting previously unselected package gfortran-14. 113s Preparing to unpack .../28-gfortran-14_14.2.0-17ubuntu3_amd64.deb ... 113s Unpacking gfortran-14 (14.2.0-17ubuntu3) ... 113s Selecting previously unselected package gfortran-x86-64-linux-gnu. 113s Preparing to unpack .../29-gfortran-x86-64-linux-gnu_4%3a14.2.0-1ubuntu1_amd64.deb ... 113s Unpacking gfortran-x86-64-linux-gnu (4:14.2.0-1ubuntu1) ... 113s Selecting previously unselected package gfortran. 113s Preparing to unpack .../30-gfortran_4%3a14.2.0-1ubuntu1_amd64.deb ... 113s Unpacking gfortran (4:14.2.0-1ubuntu1) ... 113s Selecting previously unselected package icu-devtools. 113s Preparing to unpack .../31-icu-devtools_76.1-1ubuntu2_amd64.deb ... 113s Unpacking icu-devtools (76.1-1ubuntu2) ... 113s Selecting previously unselected package libblas-dev:amd64. 113s Preparing to unpack .../32-libblas-dev_3.12.1-2_amd64.deb ... 113s Unpacking libblas-dev:amd64 (3.12.1-2) ... 113s Selecting previously unselected package libbz2-dev:amd64. 113s Preparing to unpack .../33-libbz2-dev_1.0.8-6_amd64.deb ... 113s Unpacking libbz2-dev:amd64 (1.0.8-6) ... 113s Selecting previously unselected package libdeflate-dev:amd64. 113s Preparing to unpack .../34-libdeflate-dev_1.23-1_amd64.deb ... 113s Unpacking libdeflate-dev:amd64 (1.23-1) ... 113s Selecting previously unselected package libicu-dev:amd64. 113s Preparing to unpack .../35-libicu-dev_76.1-1ubuntu2_amd64.deb ... 113s Unpacking libicu-dev:amd64 (76.1-1ubuntu2) ... 113s Selecting previously unselected package libjpeg-turbo8-dev:amd64. 113s Preparing to unpack .../36-libjpeg-turbo8-dev_2.1.5-3ubuntu2_amd64.deb ... 113s Unpacking libjpeg-turbo8-dev:amd64 (2.1.5-3ubuntu2) ... 113s Selecting previously unselected package libjpeg8-dev:amd64. 113s Preparing to unpack .../37-libjpeg8-dev_8c-2ubuntu11_amd64.deb ... 113s Unpacking libjpeg8-dev:amd64 (8c-2ubuntu11) ... 113s Selecting previously unselected package libjpeg-dev:amd64. 113s Preparing to unpack .../38-libjpeg-dev_8c-2ubuntu11_amd64.deb ... 113s Unpacking libjpeg-dev:amd64 (8c-2ubuntu11) ... 113s Selecting previously unselected package liblapack-dev:amd64. 113s Preparing to unpack .../39-liblapack-dev_3.12.1-2_amd64.deb ... 113s Unpacking liblapack-dev:amd64 (3.12.1-2) ... 114s Selecting previously unselected package libncurses-dev:amd64. 114s Preparing to unpack .../40-libncurses-dev_6.5+20250216-1_amd64.deb ... 114s Unpacking libncurses-dev:amd64 (6.5+20250216-1) ... 114s Selecting previously unselected package libpcre2-16-0:amd64. 114s Preparing to unpack .../41-libpcre2-16-0_10.45-1_amd64.deb ... 114s Unpacking libpcre2-16-0:amd64 (10.45-1) ... 114s Selecting previously unselected package libpcre2-32-0:amd64. 114s Preparing to unpack .../42-libpcre2-32-0_10.45-1_amd64.deb ... 114s Unpacking libpcre2-32-0:amd64 (10.45-1) ... 114s Selecting previously unselected package libpcre2-posix3:amd64. 114s Preparing to unpack .../43-libpcre2-posix3_10.45-1_amd64.deb ... 114s Unpacking libpcre2-posix3:amd64 (10.45-1) ... 114s Selecting previously unselected package libpcre2-dev:amd64. 114s Preparing to unpack .../44-libpcre2-dev_10.45-1_amd64.deb ... 114s Unpacking libpcre2-dev:amd64 (10.45-1) ... 114s Selecting previously unselected package libpkgconf3:amd64. 114s Preparing to unpack .../45-libpkgconf3_1.8.1-4_amd64.deb ... 114s Unpacking libpkgconf3:amd64 (1.8.1-4) ... 114s Selecting previously unselected package zlib1g-dev:amd64. 114s Preparing to unpack .../46-zlib1g-dev_1%3a1.3.dfsg+really1.3.1-1ubuntu1_amd64.deb ... 114s Unpacking zlib1g-dev:amd64 (1:1.3.dfsg+really1.3.1-1ubuntu1) ... 114s Selecting previously unselected package libpng-dev:amd64. 114s Preparing to unpack .../47-libpng-dev_1.6.47-1_amd64.deb ... 114s Unpacking libpng-dev:amd64 (1.6.47-1) ... 114s Selecting previously unselected package libreadline-dev:amd64. 114s Preparing to unpack .../48-libreadline-dev_8.2-6_amd64.deb ... 114s Unpacking libreadline-dev:amd64 (8.2-6) ... 114s 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.../54-pkg-r-autopkgtest_20231212ubuntu1_all.deb ... 114s Unpacking pkg-r-autopkgtest (20231212ubuntu1) ... 114s Setting up libjpeg-turbo8-dev:amd64 (2.1.5-3ubuntu2) ... 114s Setting up libncurses-dev:amd64 (6.5+20250216-1) ... 114s Setting up libreadline-dev:amd64 (8.2-6) ... 114s Setting up libpcre2-16-0:amd64 (10.45-1) ... 114s Setting up libpcre2-32-0:amd64 (10.45-1) ... 114s Setting up libtirpc-dev:amd64 (1.3.4+ds-1.3) ... 114s Setting up libpkgconf3:amd64 (1.8.1-4) ... 114s Setting up libquadmath0:amd64 (15-20250213-1ubuntu1) ... 114s Setting up libmpc3:amd64 (1.3.1-1build2) ... 114s Setting up icu-devtools (76.1-1ubuntu2) ... 114s Setting up pkgconf-bin (1.8.1-4) ... 114s Setting up liblzma-dev:amd64 (5.6.3-1) ... 114s Setting up libubsan1:amd64 (15-20250213-1ubuntu1) ... 114s Setting up zlib1g-dev:amd64 (1:1.3.dfsg+really1.3.1-1ubuntu1) ... 114s Setting up libpcre2-posix3:amd64 (10.45-1) ... 114s Setting up libhwasan0:amd64 (15-20250213-1ubuntu1) ... 114s Setting up libasan8:amd64 (15-20250213-1ubuntu1) ... 114s Setting up libtsan2:amd64 (15-20250213-1ubuntu1) ... 114s Setting up libjpeg8-dev:amd64 (8c-2ubuntu11) ... 114s Setting up libisl23:amd64 (0.27-1) ... 114s Setting up libdeflate-dev:amd64 (1.23-1) ... 114s Setting up libicu-dev:amd64 (76.1-1ubuntu2) ... 114s Setting up libcc1-0:amd64 (15-20250213-1ubuntu1) ... 114s Setting up liblsan0:amd64 (15-20250213-1ubuntu1) ... 114s Setting up libblas-dev:amd64 (3.12.1-2) ... 114s update-alternatives: using /usr/lib/x86_64-linux-gnu/blas/libblas.so to provide /usr/lib/x86_64-linux-gnu/libblas.so (libblas.so-x86_64-linux-gnu) in auto mode 114s Setting up dctrl-tools (2.24-3build3) ... 114s Setting up libitm1:amd64 (15-20250213-1ubuntu1) ... 114s Setting up libbz2-dev:amd64 (1.0.8-6) ... 114s Setting up libpcre2-dev:amd64 (10.45-1) ... 114s Setting up libpng-dev:amd64 (1.6.47-1) ... 114s Setting up libjpeg-dev:amd64 (8c-2ubuntu11) ... 114s Setting up pkgconf:amd64 (1.8.1-4) ... 114s Setting up liblapack-dev:amd64 (3.12.1-2) ... 114s update-alternatives: using /usr/lib/x86_64-linux-gnu/lapack/liblapack.so to provide /usr/lib/x86_64-linux-gnu/liblapack.so (liblapack.so-x86_64-linux-gnu) in auto mode 114s Setting up cpp-14-x86-64-linux-gnu (14.2.0-17ubuntu3) ... 114s Setting up cpp-14 (14.2.0-17ubuntu3) ... 114s Setting up libgcc-14-dev:amd64 (14.2.0-17ubuntu3) ... 114s Setting up libstdc++-14-dev:amd64 (14.2.0-17ubuntu3) ... 114s Setting up cpp-x86-64-linux-gnu (4:14.2.0-1ubuntu1) ... 114s Setting up libgfortran-14-dev:amd64 (14.2.0-17ubuntu3) ... 114s Setting up cpp (4:14.2.0-1ubuntu1) ... 114s Setting up gcc-14-x86-64-linux-gnu (14.2.0-17ubuntu3) ... 114s Setting up gcc-x86-64-linux-gnu (4:14.2.0-1ubuntu1) ... 114s Setting up gcc-14 (14.2.0-17ubuntu3) ... 114s Setting up gfortran-14-x86-64-linux-gnu (14.2.0-17ubuntu3) ... 114s Setting up g++-14-x86-64-linux-gnu (14.2.0-17ubuntu3) ... 114s Setting up g++-x86-64-linux-gnu (4:14.2.0-1ubuntu1) ... 114s Setting up g++-14 (14.2.0-17ubuntu3) ... 114s Setting up gfortran-14 (14.2.0-17ubuntu3) ... 114s Setting up gfortran-x86-64-linux-gnu (4:14.2.0-1ubuntu1) ... 114s Setting up gcc (4:14.2.0-1ubuntu1) ... 114s Setting up g++ (4:14.2.0-1ubuntu1) ... 114s update-alternatives: using /usr/bin/g++ to provide /usr/bin/c++ (c++) in auto mode 114s Setting up build-essential (12.10ubuntu1) ... 114s Setting up gfortran (4:14.2.0-1ubuntu1) ... 114s update-alternatives: using /usr/bin/gfortran to provide /usr/bin/f95 (f95) in auto mode 114s update-alternatives: warning: skip creation of /usr/share/man/man1/f95.1.gz because associated file /usr/share/man/man1/gfortran.1.gz (of link group f95) doesn't exist 114s update-alternatives: using /usr/bin/gfortran to provide /usr/bin/f77 (f77) in auto mode 114s update-alternatives: warning: skip creation of /usr/share/man/man1/f77.1.gz because associated file /usr/share/man/man1/gfortran.1.gz (of link group f77) doesn't exist 114s Setting up r-base-dev (4.4.2-1build1) ... 114s Setting up pkg-r-autopkgtest (20231212ubuntu1) ... 114s Processing triggers for libc-bin (2.40-4ubuntu1) ... 114s Processing triggers for man-db (2.13.0-1) ... 116s Processing triggers for install-info (7.1.1-1) ... 116s autopkgtest [05:01:30]: test pkg-r-autopkgtest: /usr/share/dh-r/pkg-r-autopkgtest 116s autopkgtest [05:01:30]: test pkg-r-autopkgtest: [----------------------- 117s Test: Try to load the R library DoseFinding 117s 117s R version 4.4.2 (2024-10-31) -- "Pile of Leaves" 117s Copyright (C) 2024 The R Foundation for Statistical Computing 117s Platform: x86_64-pc-linux-gnu 117s 117s R is free software and comes with ABSOLUTELY NO WARRANTY. 117s You are welcome to redistribute it under certain conditions. 117s Type 'license()' or 'licence()' for distribution details. 117s 117s R is a collaborative project with many contributors. 117s Type 'contributors()' for more information and 117s 'citation()' on how to cite R or R packages in publications. 117s 117s Type 'demo()' for some demos, 'help()' for on-line help, or 117s 'help.start()' for an HTML browser interface to help. 117s Type 'q()' to quit R. 117s 117s > library('DoseFinding') 117s > 117s > 117s Other tests are currently unsupported! 117s They will be progressively added. 118s autopkgtest [05:01:32]: test pkg-r-autopkgtest: -----------------------] 118s autopkgtest [05:01:32]: test pkg-r-autopkgtest: - - - - - - - - - - results - - - - - - - - - - 118s pkg-r-autopkgtest PASS 118s autopkgtest [05:01:32]: @@@@@@@@@@@@@@@@@@@@ summary 118s run-unit-test PASS 118s pkg-r-autopkgtest PASS 140s nova [W] Skipping flock for amd64 140s Creating nova instance adt-plucky-amd64-r-cran-dosefinding-20250304-045934-juju-7f2275-prod-proposed-migration-environment-20-359108a5-42a9-4167-9a53-fd454b4edb04 from image adt/ubuntu-plucky-amd64-server-20250304.img (UUID 23a7ab2d-c17b-4d7b-a212-28410527d63f)... 140s nova [W] Timed out waiting for c93ae4aa-de45-45da-9bf5-2f134db260be to get deleted.